SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1rz8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_2
(TRANSTHYRETIN)		 1rz8 FAB 17B HEAVY CHAIN
(Homo
sapiens) 		4 / 7 ALA B  93
SER B  33
THR B  35
VAL B  37
 None
 0.47A 1dvxB-1rz8B:
undetectable		 1dvxB-1rz8B:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1867_0
(FPRA)		 1rz8 FAB 17B HEAVY CHAIN
(Homo
sapiens) 		4 / 4 ALA B  40
ARG B  38
GLN B  43
GLU B  46
 None
 0.81A 1lqtB-1rz8B:
0.0		 1lqtB-1rz8B:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1424_0
(FPRA)		 1rz8 FAB 17B HEAVY CHAIN
(Homo
sapiens) 		4 / 4 ALA B  40
ARG B  38
GLN B  43
GLU B  46
 None
 0.85A 1lquB-1rz8B:
0.0		 1lquB-1rz8B:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_B_1FLB500_1
(TRANSTHYRETIN)		 1rz8 FAB 17B HEAVY CHAIN
(Homo
sapiens) 		4 / 6 ALA B  93
SER B  33
THR B  35
VAL B  37
 None
 0.61A 3d2tB-1rz8B:
undetectable		 3d2tB-1rz8B:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_B_T44B128_1
(TRANSTHYRETIN)		 1rz8 FAB 17B HEAVY CHAIN
(Homo
sapiens) 		4 / 7 ALA B  93
SER B  33
THR B  35
VAL B  37
 None
 0.39A 3ozkB-1rz8B:
0.0		 3ozkB-1rz8B:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_B_IMNB201_1
(TRANSTHYRETIN)		 1rz8 FAB 17B HEAVY CHAIN
(Homo
sapiens) 		4 / 8 ALA B  93
SER B  33
THR B  35
VAL B  37
 None
 0.46A 4ik7B-1rz8B:
undetectable		 4ik7B-1rz8B:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_A_15UA301_1
(THROMBIN HEAVY CHAIN)		 1rz8 FAB 17B HEAVY CHAIN
(Homo
sapiens) 		5 / 10 TYR B  90
LEU B  80
LEU B 100
ALA B  93
GLY B  49
 None
 0.99A 4rn6A-1rz8B:
0.0		 4rn6A-1rz8B:
22.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MTH_A_ACTA302_0
(ANTIBODY FAB HEAVY
CHAIN)		 1rz8 FAB 17B HEAVY CHAIN
(Homo
sapiens) 		4 / 5 SER B 112
ALA B 114
PHE B 146
LEU B 170
 None
 0.35A 5mthA-1rz8B:
17.3		 5mthA-1rz8B:
56.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 1rz8 FAB 17B HEAVY CHAIN
(Homo
sapiens) 		5 / 12 VAL B 207
THR B 205
VAL B 211
GLY B 118
VAL B 152
 None
 1.00A 6drzA-1rz8B:
undetectable		 6drzA-1rz8B:
19.17