SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1rzm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1rzm PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE
(Thermotoga
maritima) 		4 / 5 ILE A  83
LEU A  85
VAL A 124
ALA A 114
 None
 0.95A 1mz9C-1rzmA:
undetectable		 1mz9C-1rzmA:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1rzm PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE
(Thermotoga
maritima) 		4 / 7 ILE A 183
ARG A 208
ALA A 254
ILE A 258
 None
 0.85A 2xkwA-1rzmA:
undetectable		 2xkwA-1rzmA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XNR_A_ACTA1001_0
(NUCLEAR
POLYADENYLATED
RNA-BINDING PROTEIN
3)		 1rzm PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE
(Thermotoga
maritima) 		3 / 3 SER A 271
ARG A 247
GLN A 312
 None
None
CD  A8001 ( 4.7A)
 0.94A 2xnrA-1rzmA:
3.4		 2xnrA-1rzmA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA802_1
(PROSTAGLANDIN
REDUCTASE 1)		 1rzm PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE
(Thermotoga
maritima) 		4 / 7 ARG A 276
ASN A 248
GLY A 238
ASP A 251
 None
 0.94A 2y05A-1rzmA:
2.2
2y05B-1rzmA:
2.2		 2y05A-1rzmA:
24.31
2y05B-1rzmA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1rzm PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE
(Thermotoga
maritima) 		5 / 9 ALA A 292
PHE A  95
LEU A 205
VAL A 162
ILE A 233
 None
 1.37A 3claA-1rzmA:
0.0		 3claA-1rzmA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)		 1rzm PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE
(Thermotoga
maritima) 		5 / 12 MET A   1
VAL A  17
ALA A  21
ALA A  50
ILE A  30
 None
 1.22A 3dl9B-1rzmA:
undetectable		 3dl9B-1rzmA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		 1rzm PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE
(Thermotoga
maritima) 		5 / 12 LEU A 142
ALA A 129
LEU A 147
LEU A 110
MET A 109
 None
 1.16A 3hm1A-1rzmA:
undetectable		 3hm1A-1rzmA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		 1rzm PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE
(Thermotoga
maritima) 		5 / 11 ILE A 233
ILE A 224
GLU A 164
PRO A 203
VAL A 162
 None
None
PEP  A8002 ( 4.8A)
None
None
 1.11A 3tmzA-1rzmA:
undetectable		 3tmzA-1rzmA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)		 1rzm PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE
(Thermotoga
maritima) 		6 / 12 VAL A 268
LEU A 329
VAL A 290
ALA A 286
SER A 284
LEU A 283
 None
 1.32A 4coxA-1rzmA:
undetectable		 4coxA-1rzmA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 1rzm PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE
(Thermotoga
maritima) 		4 / 6 ILE A  83
THR A  81
VAL A 162
ASP A 269
 None
 1.12A 4iaqA-1rzmA:
0.0		 4iaqA-1rzmA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1rzm PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE
(Thermotoga
maritima) 		5 / 12 VAL A 297
ILE A 281
LEU A 329
LEU A 322
ALA A 287
 None
 1.09A 4m11C-1rzmA:
0.0		 4m11C-1rzmA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_D_MXMD606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1rzm PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE
(Thermotoga
maritima) 		5 / 12 VAL A 297
ILE A 281
LEU A 329
LEU A 322
ALA A 287
 None
 1.10A 4m11D-1rzmA:
0.0		 4m11D-1rzmA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_A_LURA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1rzm PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE
(Thermotoga
maritima) 		6 / 12 VAL A 268
LEU A 329
VAL A 290
ALA A 286
SER A 284
LEU A 283
 None
 1.40A 4rrxA-1rzmA:
undetectable		 4rrxA-1rzmA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_B_LURB706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1rzm PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE
(Thermotoga
maritima) 		6 / 12 VAL A 268
LEU A 329
VAL A 290
ALA A 286
SER A 284
LEU A 283
 None
 1.41A 4rrxB-1rzmA:
undetectable		 4rrxB-1rzmA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1rzm PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE
(Thermotoga
maritima) 		5 / 7 GLY A 294
LEU A 267
LEU A 125
ILE A  90
GLY A  91
 None
 1.31A 5vkqA-1rzmA:
undetectable
5vkqB-1rzmA:
undetectable		 5vkqA-1rzmA:
12.17
5vkqB-1rzmA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_0
(REGULATORY PROTEIN
TETR)		 1rzm PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE
(Thermotoga
maritima) 		5 / 12 MET A 159
ALA A 153
GLU A 148
VAL A 104
TYR A 130
 None
 1.26A 5vlmB-1rzmA:
undetectable		 5vlmB-1rzmA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_0
(REGULATORY PROTEIN
TETR)		 1rzm PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE
(Thermotoga
maritima) 		5 / 12 GLN A 189
SER A 220
GLU A 222
LEU A 194
CYH A 235
 None
 1.36A 5vlmF-1rzmA:
undetectable		 5vlmF-1rzmA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1rzm PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE
(Thermotoga
maritima) 		5 / 12 LEU A 205
ILE A  98
GLY A 294
VAL A  88
ILE A  90
 None
 1.01A 5ycnA-1rzmA:
undetectable		 5ycnA-1rzmA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA607_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 1rzm PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE
(Thermotoga
maritima) 		4 / 4 GLY A 274
ARG A 237
ASN A 248
LEU A 250
 None
PEP  A8002 (-3.9A)
None
None
 1.18A 6b58A-1rzmA:
undetectable		 6b58A-1rzmA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPL_B_PA1B605_1
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 1rzm PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE
(Thermotoga
maritima) 		3 / 3 ARG A 247
ARG A 126
ARG A 133
 None
PEP  A8002 (-3.2A)
E4P  A8003 (-4.1A)
 1.08A 6bplA-1rzmA:
undetectable
6bplB-1rzmA:
0.8		 6bplA-1rzmA:
16.85
6bplB-1rzmA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPL_B_PA1B605_1
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 1rzm PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE
(Thermotoga
maritima) 		3 / 3 ARG A 247
ARG A 126
ARG A 237
 None
PEP  A8002 (-3.2A)
PEP  A8002 (-3.9A)
 1.09A 6bplA-1rzmA:
undetectable
6bplB-1rzmA:
0.8		 6bplA-1rzmA:
16.85
6bplB-1rzmA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)		 1rzm PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE
(Thermotoga
maritima) 		5 / 12 GLY A 275
GLY A 274
VAL A 268
ARG A 247
GLY A 238
 None
 1.17A 6gneA-1rzmA:
2.0		 6gneA-1rzmA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)		 1rzm PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE
(Thermotoga
maritima) 		5 / 12 GLY A 275
GLY A 274
VAL A 268
ARG A 247
GLY A 238
 None
 1.16A 6gneB-1rzmA:
2.4		 6gneB-1rzmA:
20.68