SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1rzr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1rzr GLUCOSE-RESISTANCE
AMYLASE REGULATOR
(Bacillus
megaterium) 		5 / 12 ILE G  73
ILE G 121
LEU G  95
VAL G  65
ILE G  67
 None
 0.99A 1oipA-1rzrG:
undetectable		 1oipA-1rzrG:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_A_ADNA1_1
(YTAA PROTEIN)		 1rzr GLUCOSE-RESISTANCE
AMYLASE REGULATOR
(Bacillus
megaterium) 		4 / 7 ILE G 154
ILE G  66
LEU G 109
ILE G 120
 None
 0.77A 2q83A-1rzrG:
undetectable		 2q83A-1rzrG:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1rzr GLUCOSE-RESISTANCE
AMYLASE REGULATOR
(Bacillus
megaterium) 		4 / 7 ILE G 121
LEU G 305
ARG G  80
THR G  87
 None
 1.19A 2zxwN-1rzrG:
0.0
2zxwW-1rzrG:
0.0		 2zxwN-1rzrG:
20.77
2zxwW-1rzrG:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1rzr GLUCOSE-RESISTANCE
AMYLASE REGULATOR
(Bacillus
megaterium) 		4 / 5 LEU G 279
THR G 277
GLU G 249
HIS G 256
 None
 1.31A 3n58C-1rzrG:
undetectable		 3n58C-1rzrG:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1478_0
(MJ0495-LIKE PROTEIN)		 1rzr GLUCOSE-RESISTANCE
AMYLASE REGULATOR
(Bacillus
megaterium) 		4 / 7 ASP G 248
GLY G 253
SER G 280
THR G 277
 None
 0.85A 4ac9C-1rzrG:
3.0		 4ac9C-1rzrG:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CCQ_A_ACTA1317_0
(THIOREDOXIN
REDUCTASE)		 1rzr GLUCOSE-RESISTANCE
AMYLASE REGULATOR
(Bacillus
megaterium) 		3 / 3 LEU G 135
GLU G 134
SER G 138
 None
 0.79A 4ccqA-1rzrG:
5.9		 4ccqA-1rzrG:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_C_IMNC701_1
(CYCLOOXYGENASE-2)		 1rzr GLUCOSE-RESISTANCE
AMYLASE REGULATOR
(Bacillus
megaterium) 		5 / 12 LEU G 233
VAL G 254
GLY G 257
ALA G 258
LEU G 263
 None
 1.16A 4coxC-1rzrG:
undetectable		 4coxC-1rzrG:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		 1rzr GLUCOSE-RESISTANCE
AMYLASE REGULATOR
(Bacillus
megaterium) 		5 / 12 SER G 330
LEU G 287
ALA G 258
ASP G 224
GLY G 226
 None
 1.43A 4j7xA-1rzrG:
3.0		 4j7xA-1rzrG:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_2
(TUBULIN BETA CHAIN)		 1rzr GLUCOSE-RESISTANCE
AMYLASE REGULATOR
(Bacillus
megaterium) 		5 / 11 LEU G 234
ASN G 179
ALA G 181
VAL G 217
ILE G 243
 None
 1.09A 4x20D-1rzrG:
undetectable		 4x20D-1rzrG:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_B_IMNB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1rzr GLUCOSE-RESISTANCE
AMYLASE REGULATOR
(Bacillus
megaterium) 		5 / 11 GLY G  64
ILE G  70
LEU G  78
ILE G 121
MET G 302
 None
 1.15A 4xumB-1rzrG:
undetectable		 4xumB-1rzrG:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1rzr GLUCOSE-RESISTANCE
AMYLASE REGULATOR
(Bacillus
megaterium) 		4 / 6 ILE G 121
LEU G 305
ARG G  80
THR G  87
 None
 1.06A 5b1aN-1rzrG:
0.0
5b1aW-1rzrG:
undetectable		 5b1aN-1rzrG:
20.77
5b1aW-1rzrG:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1rzr GLUCOSE-RESISTANCE
AMYLASE REGULATOR
(Bacillus
megaterium) 		5 / 10 ALA G 145
HIS G 131
ILE G 121
SER G 147
ALA G 146
 None
 1.18A 5eeuQ-1rzrG:
undetectable
5eeuR-1rzrG:
undetectable		 5eeuQ-1rzrG:
13.55
5eeuR-1rzrG:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1rzr GLUCOSE-RESISTANCE
AMYLASE REGULATOR
(Bacillus
megaterium) 		5 / 10 ALA G 145
HIS G 131
ILE G 121
SER G 147
ALA G 146
 None
 1.17A 5eevQ-1rzrG:
undetectable
5eevR-1rzrG:
undetectable		 5eevQ-1rzrG:
13.55
5eevR-1rzrG:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1rzr GLUCOSE-RESISTANCE
AMYLASE REGULATOR
(Bacillus
megaterium) 		5 / 10 ALA G 145
HIS G 131
ILE G 121
SER G 147
ALA G 146
 None
 1.17A 5eewQ-1rzrG:
undetectable
5eewR-1rzrG:
undetectable		 5eewQ-1rzrG:
13.55
5eewR-1rzrG:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1rzr GLUCOSE-RESISTANCE
AMYLASE REGULATOR
(Bacillus
megaterium) 		5 / 12 ILE G  73
ILE G 121
LEU G  95
VAL G  65
ILE G  67
 None
 0.97A 5mueA-1rzrG:
undetectable		 5mueA-1rzrG:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 1rzr GLUCOSE-RESISTANCE
AMYLASE REGULATOR
(Bacillus
megaterium) 		5 / 6 LEU G 113
VAL G 117
THR G  62
LEU G 144
GLU G 105
 None
 1.50A 5tudD-1rzrG:
undetectable		 5tudD-1rzrG:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_K_PACK1_0
(SERINE PROTEASE NS3
PEPTIDE
PAC-DLY-DLY-DAR)		 1rzr GLUCOSE-RESISTANCE
AMYLASE REGULATOR
(Bacillus
megaterium) 		3 / 3 ALA G 242
VAL G 211
TYR G 215
 None
 0.62A 5zmqH-1rzrG:
undetectable		 5zmqH-1rzrG:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_A_9KLA402_0
(EST-Y29)		 1rzr GLUCOSE-RESISTANCE
AMYLASE REGULATOR
(Bacillus
megaterium) 		5 / 12 TYR G 200
ILE G 272
LEU G 172
GLY G 199
LEU G 204
 None
 1.18A 5zwrA-1rzrG:
undetectable		 5zwrA-1rzrG:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_F_EY4F500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1rzr GLUCOSE-RESISTANCE
AMYLASE REGULATOR
(Bacillus
megaterium) 		4 / 7 ALA G  86
THR G  87
ILE G  94
VAL G  63
 None
 0.93A 6cduF-1rzrG:
undetectable
6cduJ-1rzrG:
undetectable		 6cduF-1rzrG:
22.10
6cduJ-1rzrG:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_0
(STIE PROTEIN)		 1rzr GLUCOSE-RESISTANCE
AMYLASE REGULATOR
(Bacillus
megaterium) 		5 / 12 LEU G 144
GLY G  64
GLY G 119
ILE G  82
ILE G  67
 None
 1.01A 6ecxA-1rzrG:
undetectable		 6ecxA-1rzrG:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 1rzr GLUCOSE-RESISTANCE
AMYLASE REGULATOR
(Bacillus
megaterium) 		4 / 6 LEU G 233
ALA G 181
SER G 214
ASN G 192
 None
None
SO4  G 647 (-3.5A)
None
 0.88A 6f88A-1rzrG:
undetectable		 6f88A-1rzrG:
12.95