SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1s04'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		 1s04 HYPOTHETICAL PROTEIN
PF0455
(Pyrococcus
furiosus) 		3 / 3 PHE A  11
TYR A  90
TYR A  86
 None
 1.05A 1x70B-1s04A:
undetectable		 1x70B-1s04A:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 1s04 HYPOTHETICAL PROTEIN
PF0455
(Pyrococcus
furiosus) 		4 / 8 ILE A  40
ARG A  25
ILE A 103
ILE A 105
 None
 0.85A 2bu8A-1s04A:
undetectable		 2bu8A-1s04A:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRH_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 1s04 HYPOTHETICAL PROTEIN
PF0455
(Pyrococcus
furiosus) 		5 / 12 PHE A  11
ILE A 105
LYS A  30
ILE A  34
PHE A  42
 None
 1.33A 4drhA-1s04A:
undetectable		 4drhA-1s04A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA401_0
(PROTON-GATED ION
CHANNEL)		 1s04 HYPOTHETICAL PROTEIN
PF0455
(Pyrococcus
furiosus) 		4 / 6 ILE A  40
ARG A  31
ILE A 103
GLU A  23
 None
 1.30A 4zzcA-1s04A:
undetectable
4zzcB-1s04A:
undetectable		 4zzcA-1s04A:
15.77
4zzcB-1s04A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB401_0
(PROTON-GATED ION
CHANNEL)		 1s04 HYPOTHETICAL PROTEIN
PF0455
(Pyrococcus
furiosus) 		4 / 6 ILE A  40
ARG A  31
ILE A 103
GLU A  23
 None
 1.28A 4zzcB-1s04A:
undetectable
4zzcC-1s04A:
undetectable		 4zzcB-1s04A:
15.77
4zzcC-1s04A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_4_BEZ4801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1s04 HYPOTHETICAL PROTEIN
PF0455
(Pyrococcus
furiosus) 		4 / 5 PHE A  42
ARG A  18
ILE A 105
ILE A  15
 None
 0.83A 5dzk4-1s04A:
undetectable
5dzkg-1s04A:
undetectable
5dzkm-1s04A:
undetectable
5dzkn-1s04A:
undetectable		 5dzk4-1s04A:
16.67
5dzkg-1s04A:
20.95
5dzkm-1s04A:
19.67
5dzkn-1s04A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJD_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 1s04 HYPOTHETICAL PROTEIN
PF0455
(Pyrococcus
furiosus) 		5 / 9 LEU A  26
ILE A  15
ILE A  34
LEU A   7
MET A   5
 None
 1.22A 5ljdA-1s04A:
0.0		 5ljdA-1s04A:
21.83