SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1s0h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IWH_A_PEMA501_1
(HEMOGLOBIN ALPHA
CHAIN)		 1s0h HEMOGLOBIN ALPHA
CHAIN
(Equus
asinus) 		5 / 6 ALA A  26
LYS A  60
ASP A  64
ALA A  65
LEU A  83
 None
None
None
HEM  A 142 (-3.6A)
HEM  A 142 (-4.6A)
 1.46A 1iwhA-1s0hA:
26.9		 1iwhA-1s0hA:
98.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IWH_A_PEMA501_1
(HEMOGLOBIN ALPHA
CHAIN)		 1s0h HEMOGLOBIN ALPHA
CHAIN
(Equus
asinus) 		5 / 6 ALA A  57
LYS A  60
ASP A  64
ALA A  65
LEU A  83
 None
None
None
HEM  A 142 (-3.6A)
HEM  A 142 (-4.6A)
 1.03A 1iwhA-1s0hA:
26.9		 1iwhA-1s0hA:
98.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 1s0h HEMOGLOBIN ALPHA
CHAIN
(Equus
asinus) 		4 / 7 PHE A  43
PHE A  46
VAL A  62
HIS A  87
 HEM  A 142 (-4.1A)
None
HEM  A 142 ( 4.5A)
HEM  A 142 (-3.3A)
 0.90A 1lh6A-1s0hA:
12.6		 1lh6A-1s0hA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1s0h HEMOGLOBIN ALPHA
CHAIN
(Equus
asinus) 		3 / 3 LEU A 129
VAL A 132
LEU A 136
 None
 0.51A 1mz9B-1s0hA:
undetectable		 1mz9B-1s0hA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2002_1
(SERUM ALBUMIN)		 1s0h HEMOGLOBIN ALPHA
CHAIN
(Equus
asinus) 		5 / 10 ALA A  69
LEU A  76
SER A  84
LEU A 136
VAL A 135
 None
 1.14A 2bxeA-1s0hA:
undetectable		 2bxeA-1s0hA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXP_A_P1ZA3001_1
(SERUM ALBUMIN)		 1s0h HEMOGLOBIN ALPHA
CHAIN
(Equus
asinus) 		5 / 12 PHE A 128
LEU A 136
HIS A  87
ALA A  79
ALA A  65
 None
None
HEM  A 142 (-3.3A)
None
HEM  A 142 (-3.6A)
 0.97A 2bxpA-1s0hA:
2.3		 2bxpA-1s0hA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		 1s0h HEMOGLOBIN ALPHA
CHAIN
(Equus
asinus) 		5 / 12 LEU A  29
GLY A  25
PHE A  98
LEU A 136
VAL A  17
 None
None
HEM  A 142 (-3.4A)
None
None
 1.42A 2w8yA-1s0hA:
undetectable		 2w8yA-1s0hA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 1s0h HEMOGLOBIN ALPHA
CHAIN
(Equus
asinus) 		3 / 3 PHE A  46
SER A  52
GLN A  54
 None
 0.83A 3smtA-1s0hA:
undetectable		 3smtA-1s0hA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFX_A_ACTA404_0
(THIAMINE
BIOSYNTHESIS
LIPOPROTEIN APBE)		 1s0h HEMOGLOBIN ALPHA
CHAIN
(Equus
asinus) 		4 / 5 SER A 102
LYS A  99
LEU A 129
ASP A 126
 None
 1.34A 4ifxA-1s0hA:
undetectable		 4ifxA-1s0hA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG1_A_ACTA504_0
(FAD:PROTEIN FMN
TRANSFERASE)		 1s0h HEMOGLOBIN ALPHA
CHAIN
(Equus
asinus) 		4 / 5 SER A 102
LYS A  99
LEU A 129
ASP A 126
 None
 1.31A 4ig1A-1s0hA:
undetectable		 4ig1A-1s0hA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA406_0
(FAD:PROTEIN FMN
TRANSFERASE)		 1s0h HEMOGLOBIN ALPHA
CHAIN
(Equus
asinus) 		4 / 5 SER A 102
LYS A  99
LEU A 129
ASP A 126
 None
 1.34A 4xdtA-1s0hA:
0.0		 4xdtA-1s0hA:
21.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X2S_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 1s0h HEMOGLOBIN ALPHA
CHAIN
(Equus
asinus) 		4 / 8 PRO A  95
THR A 134
THR A 137
TYR A 140
 None
 0.58A 5x2sI-1s0hA:
24.9
5x2sJ-1s0hA:
20.8
5x2sK-1s0hA:
25.5		 5x2sI-1s0hA:
86.52
5x2sJ-1s0hA:
43.24
5x2sK-1s0hA:
86.52