SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1s0p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK6_A_LNLA1201_1
(NON-SPECIFIC LIPID
TRANSFER PROTEIN)		 1s0p ADENYLYL
CYCLASE-ASSOCIATED
PROTEIN
(Dictyostelium
discoideum) 		5 / 12 VAL A 153
LEU A 213
ALA A  98
LEU A  94
ALA A  90
 None
 1.02A 1fk6A-1s0pA:
0.2		 1fk6A-1s0pA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2888_0
(AMINOMETHYLTRANSFERA
SE)		 1s0p ADENYLYL
CYCLASE-ASSOCIATED
PROTEIN
(Dictyostelium
discoideum) 		5 / 10 LEU A 116
GLU A  91
LEU A  94
ILE A 113
LEU A 213
 None
 1.18A 1wopA-1s0pA:
undetectable		 1wopA-1s0pA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCD_A_RAPA138_1
(OUTER MEMBRANE
PROTEIN MIP)		 1s0p ADENYLYL
CYCLASE-ASSOCIATED
PROTEIN
(Dictyostelium
discoideum) 		5 / 11 TYR A 194
GLN A  83
VAL A  85
ILE A  88
VAL A 152
 None
 1.18A 2vcdA-1s0pA:
undetectable		 2vcdA-1s0pA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QCK_A_ASDA404_1
(3-KETOSTEROID-9-ALPH
A-MONOOXYGENASE
OXYGENASE SUBUNIT)		 1s0p ADENYLYL
CYCLASE-ASSOCIATED
PROTEIN
(Dictyostelium
discoideum) 		5 / 12 VAL A 191
ALA A 141
LEU A 139
ASN A 138
GLY A  78
 None
 1.17A 4qckA-1s0pA:
undetectable		 4qckA-1s0pA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y1D_D_DVAD5_0
(CYCLIC HEXAPEPTIDE
CYC[NDPOPPKID]
INTEGRASE)		 1s0p ADENYLYL
CYCLASE-ASSOCIATED
PROTEIN
(Dictyostelium
discoideum) 		3 / 3 GLU A  82
LYS A  71
ASN A  79
 None
 0.87A 4y1dA-1s0pA:
0.9
4y1dD-1s0pA:
undetectable		 4y1dA-1s0pA:
19.35
4y1dD-1s0pA:
3.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_C_FK5C201_1
(FK506-BINDING
PROTEIN 1)		 1s0p ADENYLYL
CYCLASE-ASSOCIATED
PROTEIN
(Dictyostelium
discoideum) 		5 / 10 TYR A 194
VAL A  85
ILE A  88
LEU A 201
PHE A 197
 None
 1.24A 5hw8C-1s0pA:
undetectable
5hw8H-1s0pA:
undetectable		 5hw8C-1s0pA:
20.90
5hw8H-1s0pA:
20.90