SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1s0u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1s0u TRANSLATION
INITIATION FACTOR 2
GAMMA SUBUNIT
(Methanocaldococc
us
jannaschii) 		4 / 5 ILE A 221
LEU A 217
VAL A 170
ALA A 143
 None
 0.91A 1mz9C-1s0uA:
undetectable		 1mz9C-1s0uA:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BL9_A_CP6A1240_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1s0u TRANSLATION
INITIATION FACTOR 2
GAMMA SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A  75
ALA A 241
LEU A 317
SER A 113
THR A 335
 None
 1.19A 2bl9A-1s0uA:
undetectable		 2bl9A-1s0uA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCF_A_ESTA596_1
(ESTROGEN RECEPTOR)		 1s0u TRANSLATION
INITIATION FACTOR 2
GAMMA SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 10 ALA A 264
LEU A 133
MET A 134
ARG A 230
LEU A  77
 None
 1.35A 2ocfA-1s0uA:
undetectable		 2ocfA-1s0uA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_F_CSCF1383_2
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 1s0u TRANSLATION
INITIATION FACTOR 2
GAMMA SUBUNIT
(Methanocaldococc
us
jannaschii) 		3 / 3 LEU A 123
MET A 127
MET A 381
 None
 0.99A 2vavF-1s0uA:
3.2		 2vavF-1s0uA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_C_TOPC1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 1s0u TRANSLATION
INITIATION FACTOR 2
GAMMA SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 10 ILE A  75
ALA A 241
LEU A 317
SER A 113
THR A 335
 None
 1.20A 2w9sC-1s0uA:
undetectable		 2w9sC-1s0uA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1s0u TRANSLATION
INITIATION FACTOR 2
GAMMA SUBUNIT
(Methanocaldococc
us
jannaschii) 		4 / 8 ALA A 264
TYR A  79
GLY A 263
ILE A 318
 None
 0.85A 2zm9A-1s0uA:
0.0		 2zm9A-1s0uA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZQ9_A_CLSA11_1
(BETA-LACTAMASE
TOHO-1)		 1s0u TRANSLATION
INITIATION FACTOR 2
GAMMA SUBUNIT
(Methanocaldococc
us
jannaschii) 		4 / 4 GLU A 436
ARG A 355
ASN A 357
ASP A 399
 None
 1.45A 2zq9A-1s0uA:
undetectable		 2zq9A-1s0uA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB2_A_IBPA3960_1
(LACTOTRANSFERRIN)		 1s0u TRANSLATION
INITIATION FACTOR 2
GAMMA SUBUNIT
(Methanocaldococc
us
jannaschii) 		4 / 4 GLY A 262
VAL A 320
GLY A 305
THR A 307
 None
 0.94A 3ib2A-1s0uA:
0.0		 3ib2A-1s0uA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_2
(PROTEASE)		 1s0u TRANSLATION
INITIATION FACTOR 2
GAMMA SUBUNIT
(Methanocaldococc
us
jannaschii) 		6 / 12 LEU A 139
GLY A  41
ILE A 221
PRO A 202
ILE A 169
ILE A 167
 None
 1.49A 3s54B-1s0uA:
undetectable		 3s54B-1s0uA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ8_A_TOPA2001_1
(DIHYDROFOLATE
REDUCTASE)		 1s0u TRANSLATION
INITIATION FACTOR 2
GAMMA SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 9 ILE A  75
ALA A 241
LEU A 317
SER A 113
THR A 335
 None
 1.11A 3tq8A-1s0uA:
undetectable		 3tq8A-1s0uA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1s0u TRANSLATION
INITIATION FACTOR 2
GAMMA SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 11 ILE A  75
ALA A 131
GLY A 130
GLY A 315
TYR A  79
 None
 1.14A 4e47A-1s0uA:
undetectable		 4e47A-1s0uA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_B_SAMB800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1s0u TRANSLATION
INITIATION FACTOR 2
GAMMA SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 11 ILE A  75
ALA A 131
GLY A 130
GLY A 315
TYR A  79
 None
 1.15A 4e47B-1s0uA:
undetectable		 4e47B-1s0uA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G8Z_X_TOPX301_1
(DIHYDROFOLATE
REDUCTASE)		 1s0u TRANSLATION
INITIATION FACTOR 2
GAMMA SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 10 ILE A  75
ALA A 241
LEU A 317
SER A 113
THR A 335
 None
 1.18A 4g8zX-1s0uA:
undetectable		 4g8zX-1s0uA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_C_SVRC301_1
(NUCLEOCAPSID PROTEIN)		 1s0u TRANSLATION
INITIATION FACTOR 2
GAMMA SUBUNIT
(Methanocaldococc
us
jannaschii) 		4 / 8 GLY A 136
ARG A 110
MET A  42
ILE A 168
 None
 1.01A 4j4vC-1s0uA:
undetectable		 4j4vC-1s0uA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1s0u TRANSLATION
INITIATION FACTOR 2
GAMMA SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 11 ILE A  75
ALA A 131
GLY A 130
GLY A 315
TYR A  79
 None
 1.18A 4jdsA-1s0uA:
undetectable		 4jdsA-1s0uA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1s0u TRANSLATION
INITIATION FACTOR 2
GAMMA SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 11 ILE A  75
ALA A 131
GLY A 130
GLY A 315
TYR A  79
 None
 1.18A 4jdsB-1s0uA:
undetectable		 4jdsB-1s0uA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1s0u TRANSLATION
INITIATION FACTOR 2
GAMMA SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 12 ALA A 401
ALA A 418
ILE A 419
ILE A 409
LEU A 405
 None
 0.90A 4r3aA-1s0uA:
undetectable		 4r3aA-1s0uA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XNX_A_41XA707_1
(TRANSPORTER)		 1s0u TRANSLATION
INITIATION FACTOR 2
GAMMA SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 11 PHE A 270
ASP A 274
ALA A 234
GLY A 340
GLY A 268
 None
 1.12A 4xnxA-1s0uA:
undetectable		 4xnxA-1s0uA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1s0u TRANSLATION
INITIATION FACTOR 2
GAMMA SUBUNIT
(Methanocaldococc
us
jannaschii) 		3 / 3 ALA A  80
TYR A  79
PRO A 118
 None
 0.68A 4zdyA-1s0uA:
undetectable		 4zdyA-1s0uA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1s0u TRANSLATION
INITIATION FACTOR 2
GAMMA SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 11 ILE A  75
ALA A 131
GLY A 130
GLY A 315
TYR A  79
 None
 1.15A 5ayfA-1s0uA:
undetectable		 5ayfA-1s0uA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1s0u TRANSLATION
INITIATION FACTOR 2
GAMMA SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 11 SER A  52
THR A  51
GLY A  59
THR A  58
ALA A  56
 None
 1.23A 5bxnV-1s0uA:
undetectable
5bxnW-1s0uA:
undetectable		 5bxnV-1s0uA:
19.81
5bxnW-1s0uA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1s0u TRANSLATION
INITIATION FACTOR 2
GAMMA SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A 336
ALA A 241
ILE A 318
ALA A 264
MET A 238
 None
 1.05A 5n0tB-1s0uA:
undetectable		 5n0tB-1s0uA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1s0u TRANSLATION
INITIATION FACTOR 2
GAMMA SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A 265
GLY A 315
ALA A 312
MET A 238
VAL A 320
 None
 0.97A 5n0tB-1s0uA:
undetectable		 5n0tB-1s0uA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFP_A_8W5A804_2
(GLUCOCORTICOID
RECEPTOR)		 1s0u TRANSLATION
INITIATION FACTOR 2
GAMMA SUBUNIT
(Methanocaldococc
us
jannaschii) 		4 / 4 LEU A 128
MET A 134
ILE A  73
LEU A 123
 None
 1.31A 5nfpA-1s0uA:
0.0		 5nfpA-1s0uA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_C_08JC602_1
(CYTOCHROME P450 3A4)		 1s0u TRANSLATION
INITIATION FACTOR 2
GAMMA SUBUNIT
(Methanocaldococc
us
jannaschii) 		4 / 7 ARG A 230
ALA A  36
ILE A 318
LEU A 309
 None
 0.88A 5te8C-1s0uA:
undetectable		 5te8C-1s0uA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7B_B_PA1B204_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)		 1s0u TRANSLATION
INITIATION FACTOR 2
GAMMA SUBUNIT
(Methanocaldococc
us
jannaschii) 		3 / 3 GLY A 316
ASN A  39
ARG A 230
 None
 0.59A 5w7bD-1s0uA:
3.4		 5w7bD-1s0uA:
11.42