SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1s14'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AJ6_A_NOVA1_1
(GYRASE)		 1s14 TOPOISOMERASE IV
SUBUNIT B
(Escherichia
coli) 		8 / 9 ASN A1042
GLU A1046
ASP A1069
ARG A1072
PRO A1075
ALA A1086
ILE A1090
THR A1163
 NOV  A1300 (-3.7A)
NOV  A1300 (-3.7A)
NOV  A1300 (-3.4A)
NOV  A1300 (-3.1A)
NOV  A1300 (-4.5A)
NOV  A1300 ( 4.3A)
NOV  A1300 ( 4.6A)
NOV  A1300 ( 4.0A)
 0.53A 1aj6A-1s14A:
23.3		 1aj6A-1s14A:
39.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		 1s14 TOPOISOMERASE IV
SUBUNIT B
(Escherichia
coli) 		9 / 12 ASP A1045
GLU A1046
ASP A1069
ARG A1072
PRO A1075
ASP A1077
ILE A1090
ARG A1132
THR A1163
 None
NOV  A1300 (-3.7A)
NOV  A1300 (-3.4A)
NOV  A1300 (-3.1A)
NOV  A1300 (-4.5A)
NOV  A1300 (-2.7A)
NOV  A1300 ( 4.6A)
NOV  A1300 (-2.9A)
NOV  A1300 ( 4.0A)
 0.31A 1kijA-1s14A:
24.0		 1kijA-1s14A:
27.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		 1s14 TOPOISOMERASE IV
SUBUNIT B
(Escherichia
coli) 		9 / 12 ASN A1042
GLU A1046
ASP A1069
ARG A1072
PRO A1075
ASP A1077
ILE A1090
ARG A1132
THR A1163
 NOV  A1300 (-3.7A)
NOV  A1300 (-3.7A)
NOV  A1300 (-3.4A)
NOV  A1300 (-3.1A)
NOV  A1300 (-4.5A)
NOV  A1300 (-2.7A)
NOV  A1300 ( 4.6A)
NOV  A1300 (-2.9A)
NOV  A1300 ( 4.0A)
 0.38A 1kijB-1s14A:
24.5		 1kijB-1s14A:
27.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 1s14 TOPOISOMERASE IV
SUBUNIT B
(Escherichia
coli) 		12 / 12 ASN A1042
SER A1043
ASP A1045
GLU A1046
ASP A1069
ARG A1072
MET A1074
PRO A1075
ASP A1077
ILE A1090
ARG A1132
THR A1163
 NOV  A1300 (-3.7A)
NOV  A1300 (-3.6A)
None
NOV  A1300 (-3.7A)
NOV  A1300 (-3.4A)
NOV  A1300 (-3.1A)
NOV  A1300 (-3.7A)
NOV  A1300 (-4.5A)
NOV  A1300 (-2.7A)
NOV  A1300 ( 4.6A)
NOV  A1300 (-2.9A)
NOV  A1300 ( 4.0A)
 0.46A 3lpsA-1s14A:
27.5		 3lpsA-1s14A:
41.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 1s14 TOPOISOMERASE IV
SUBUNIT B
(Escherichia
coli) 		11 / 11 ASN A1042
SER A1043
ASP A1045
GLU A1046
ASP A1069
ARG A1072
MET A1074
PRO A1075
ILE A1090
ARG A1132
THR A1163
 NOV  A1300 (-3.7A)
NOV  A1300 (-3.6A)
None
NOV  A1300 (-3.7A)
NOV  A1300 (-3.4A)
NOV  A1300 (-3.1A)
NOV  A1300 (-3.7A)
NOV  A1300 (-4.5A)
NOV  A1300 ( 4.6A)
NOV  A1300 (-2.9A)
NOV  A1300 ( 4.0A)
 0.79A 4urnA-1s14A:
24.9		 4urnA-1s14A:
38.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_B_NOVB2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 1s14 TOPOISOMERASE IV
SUBUNIT B
(Escherichia
coli) 		11 / 11 ASN A1042
SER A1043
ASP A1045
GLU A1046
ASP A1069
ARG A1072
MET A1074
PRO A1075
ILE A1090
ARG A1132
THR A1163
 NOV  A1300 (-3.7A)
NOV  A1300 (-3.6A)
None
NOV  A1300 (-3.7A)
NOV  A1300 (-3.4A)
NOV  A1300 (-3.1A)
NOV  A1300 (-3.7A)
NOV  A1300 (-4.5A)
NOV  A1300 ( 4.6A)
NOV  A1300 (-2.9A)
NOV  A1300 ( 4.0A)
 0.63A 4urnB-1s14A:
26.4		 4urnB-1s14A:
38.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 1s14 TOPOISOMERASE IV
SUBUNIT B
(Escherichia
coli) 		11 / 11 ASN A1042
SER A1043
ASP A1045
GLU A1046
ASP A1069
ARG A1072
MET A1074
PRO A1075
ILE A1090
ARG A1132
THR A1163
 NOV  A1300 (-3.7A)
NOV  A1300 (-3.6A)
None
NOV  A1300 (-3.7A)
NOV  A1300 (-3.4A)
NOV  A1300 (-3.1A)
NOV  A1300 (-3.7A)
NOV  A1300 (-4.5A)
NOV  A1300 ( 4.6A)
NOV  A1300 (-2.9A)
NOV  A1300 ( 4.0A)
 0.61A 4urnC-1s14A:
25.2		 4urnC-1s14A:
38.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 1s14 TOPOISOMERASE IV
SUBUNIT B
(Escherichia
coli) 		9 / 12 ASN A1042
SER A1043
GLU A1046
ASP A1069
ARG A1072
PRO A1075
ASP A1077
ILE A1090
ARG A1132
 NOV  A1300 (-3.7A)
NOV  A1300 (-3.6A)
NOV  A1300 (-3.7A)
NOV  A1300 (-3.4A)
NOV  A1300 (-3.1A)
NOV  A1300 (-4.5A)
NOV  A1300 (-2.7A)
NOV  A1300 ( 4.6A)
NOV  A1300 (-2.9A)
 0.49A 4uroA-1s14A:
26.0		 4uroA-1s14A:
37.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 1s14 TOPOISOMERASE IV
SUBUNIT B
(Escherichia
coli) 		9 / 12 ASN A1042
SER A1043
GLU A1046
ASP A1069
ARG A1072
PRO A1075
ASP A1077
ILE A1090
ARG A1132
 NOV  A1300 (-3.7A)
NOV  A1300 (-3.6A)
NOV  A1300 (-3.7A)
NOV  A1300 (-3.4A)
NOV  A1300 (-3.1A)
NOV  A1300 (-4.5A)
NOV  A1300 (-2.7A)
NOV  A1300 ( 4.6A)
NOV  A1300 (-2.9A)
 0.52A 4uroB-1s14A:
26.1		 4uroB-1s14A:
37.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		 1s14 TOPOISOMERASE IV
SUBUNIT B
(Escherichia
coli) 		9 / 12 ASN A1042
GLU A1046
ASP A1069
ARG A1072
PRO A1075
ASP A1077
ALA A1086
ILE A1090
ARG A1132
 NOV  A1300 (-3.7A)
NOV  A1300 (-3.7A)
NOV  A1300 (-3.4A)
NOV  A1300 (-3.1A)
NOV  A1300 (-4.5A)
NOV  A1300 (-2.7A)
NOV  A1300 ( 4.3A)
NOV  A1300 ( 4.6A)
NOV  A1300 (-2.9A)
 0.54A 4uroC-1s14A:
26.0		 4uroC-1s14A:
37.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		 1s14 TOPOISOMERASE IV
SUBUNIT B
(Escherichia
coli) 		10 / 12 ASN A1042
SER A1043
GLU A1046
ASP A1069
ARG A1072
PRO A1075
ASP A1077
ILE A1090
ARG A1132
THR A1163
 NOV  A1300 (-3.7A)
NOV  A1300 (-3.6A)
NOV  A1300 (-3.7A)
NOV  A1300 (-3.4A)
NOV  A1300 (-3.1A)
NOV  A1300 (-4.5A)
NOV  A1300 (-2.7A)
NOV  A1300 ( 4.6A)
NOV  A1300 (-2.9A)
NOV  A1300 ( 4.0A)
 0.50A 4uroD-1s14A:
25.1		 4uroD-1s14A:
37.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_C_PACC601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 1s14 TOPOISOMERASE IV
SUBUNIT B
(Escherichia
coli) 		5 / 12 SER A1123
PRO A1169
PHE A1179
HIS A1166
VAL A1126
 None
 1.36A 4yfbC-1s14A:
undetectable		 4yfbC-1s14A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_I_PACI601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 1s14 TOPOISOMERASE IV
SUBUNIT B
(Escherichia
coli) 		5 / 12 SER A1123
PRO A1169
PHE A1179
HIS A1166
VAL A1126
 None
 1.35A 4yfbI-1s14A:
0.0		 4yfbI-1s14A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_L_PACL601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 1s14 TOPOISOMERASE IV
SUBUNIT B
(Escherichia
coli) 		5 / 12 SER A1123
PRO A1169
PHE A1179
HIS A1166
VAL A1126
 None
 1.35A 4yfbL-1s14A:
0.0		 4yfbL-1s14A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_2
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 1s14 TOPOISOMERASE IV
SUBUNIT B
(Escherichia
coli) 		3 / 3 GLU A1171
TRP A1168
ASN A1143
 None
 1.06A 5dv4A-1s14A:
undetectable		 5dv4A-1s14A:
19.35