SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1s1d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		 1s1d APYRASE
(Homo
sapiens) 		5 / 11 ALA A  38
LEU A 100
LEU A  59
LEU A  84
ALA A  41
 None
 1.17A 1h9zA-1s1dA:
undetectable		 1h9zA-1s1dA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MOG_A_RBFA200_1
(DODECIN)		 1s1d APYRASE
(Homo
sapiens) 		3 / 3 PHE A 257
TRP A 192
GLU A 190
 None
 1.17A 1mogA-1s1dA:
undetectable		 1mogA-1s1dA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_0
(MODIFICATION
METHYLASE RSRI)		 1s1d APYRASE
(Homo
sapiens) 		5 / 12 TRP A 192
PHE A 227
SER A 263
VAL A 265
ALA A 202
 None
 1.12A 1nw5A-1s1dA:
undetectable		 1nw5A-1s1dA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_1
(PROTEASE RETROPEPSIN)		 1s1d APYRASE
(Homo
sapiens) 		5 / 10 GLY A 157
ALA A 144
ASP A 112
ILE A 101
VAL A 129
 None
None
GP2  A4001 (-4.2A)
TRS  A5001 ( 4.9A)
None
 0.85A 1t3rA-1s1dA:
undetectable		 1t3rA-1s1dA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_2
(PROTEASE)		 1s1d APYRASE
(Homo
sapiens) 		5 / 11 GLY A 157
ALA A 144
ASP A 112
ILE A 101
VAL A 129
 None
None
GP2  A4001 (-4.2A)
TRS  A5001 ( 4.9A)
None
 0.89A 2r5qB-1s1dA:
undetectable		 2r5qB-1s1dA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_2
(PROTEASE
(RETROPEPSIN))		 1s1d APYRASE
(Homo
sapiens) 		5 / 12 GLY A 157
ALA A 144
ASP A 112
ILE A 101
VAL A 129
 None
None
GP2  A4001 (-4.2A)
TRS  A5001 ( 4.9A)
None
 0.83A 3bvbB-1s1dA:
undetectable		 3bvbB-1s1dA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)		 1s1d APYRASE
(Homo
sapiens) 		3 / 3 TYR A 237
GLU A 145
ASP A 111
 GP2  A4001 (-4.2A)
GP2  A4001 ( 2.7A)
None
 0.83A 3bxoA-1s1dA:
undetectable		 3bxoA-1s1dA:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_1
(N,N-DIMETHYLTRANSFER
ASE)		 1s1d APYRASE
(Homo
sapiens) 		3 / 3 TYR A 237
GLU A 145
ASP A 111
 GP2  A4001 (-4.2A)
GP2  A4001 ( 2.7A)
None
 0.82A 3bxoB-1s1dA:
undetectable		 3bxoB-1s1dA:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_A_BEZA261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 1s1d APYRASE
(Homo
sapiens) 		4 / 8 ASN A 195
TRP A 225
TRP A 146
TYR A 196
 None
 1.35A 3ccfA-1s1dA:
undetectable		 3ccfA-1s1dA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_B_BEZB261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 1s1d APYRASE
(Homo
sapiens) 		4 / 8 ASN A 195
TRP A 225
TRP A 146
TYR A 196
 None
 1.38A 3ccfB-1s1dA:
undetectable		 3ccfB-1s1dA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_3
(HIV-1 PROTEASE)		 1s1d APYRASE
(Homo
sapiens) 		5 / 12 GLY A 157
ALA A 144
ASP A 112
ILE A 101
VAL A 129
 None
None
GP2  A4001 (-4.2A)
TRS  A5001 ( 4.9A)
None
 0.86A 3k4vB-1s1dA:
undetectable		 3k4vB-1s1dA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)		 1s1d APYRASE
(Homo
sapiens) 		4 / 7 GLY A 160
PHE A 279
PHE A 227
PHE A 277
 None
 0.98A 3ko0L-1s1dA:
undetectable
3ko0N-1s1dA:
undetectable		 3ko0L-1s1dA:
13.98
3ko0N-1s1dA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT201_1
(PROTEIN S100-A4)		 1s1d APYRASE
(Homo
sapiens) 		4 / 7 PHE A 227
PHE A 277
GLY A 160
PHE A 279
 None
 1.00A 3ko0R-1s1dA:
undetectable
3ko0T-1s1dA:
undetectable		 3ko0R-1s1dA:
13.98
3ko0T-1s1dA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_3
(PROTEASE)		 1s1d APYRASE
(Homo
sapiens) 		5 / 12 GLY A 157
ALA A 144
ASP A 112
ILE A 101
VAL A 129
 None
None
GP2  A4001 (-4.2A)
TRS  A5001 ( 4.9A)
None
 0.88A 3ndtB-1s1dA:
undetectable		 3ndtB-1s1dA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OY4_B_017B200_2
(HIV-1 PROTEASE)		 1s1d APYRASE
(Homo
sapiens) 		5 / 10 GLY A 157
ALA A 144
ASP A 112
ILE A 101
VAL A 129
 None
None
GP2  A4001 (-4.2A)
TRS  A5001 ( 4.9A)
None
 0.89A 3oy4B-1s1dA:
undetectable		 3oy4B-1s1dA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA451_1
(CYTOCHROME P450
164A2)		 1s1d APYRASE
(Homo
sapiens) 		5 / 10 ALA A 306
LEU A  64
ILE A  37
ALA A  38
VAL A 102
 None
 1.34A 3r9cA-1s1dA:
undetectable		 3r9cA-1s1dA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 1s1d APYRASE
(Homo
sapiens) 		4 / 8 ALA A  31
GLY A  32
THR A  29
THR A  65
 None
 0.92A 3rglA-1s1dA:
undetectable		 3rglA-1s1dA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)		 1s1d APYRASE
(Homo
sapiens) 		4 / 7 LEU A  59
ALA A  41
GLY A 321
ILE A 320
 None
 0.72A 3spkB-1s1dA:
undetectable		 3spkB-1s1dA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKW_B_017B401_2
(PROTEASE)		 1s1d APYRASE
(Homo
sapiens) 		5 / 12 GLY A 157
ALA A 144
ASP A 112
ILE A 101
VAL A 129
 None
None
GP2  A4001 (-4.2A)
TRS  A5001 ( 4.9A)
None
 0.86A 3tkwB-1s1dA:
undetectable		 3tkwB-1s1dA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_1
(PROTEASE)		 1s1d APYRASE
(Homo
sapiens) 		5 / 12 GLY A 157
ALA A 144
ASP A 112
ILE A 101
VAL A 129
 None
None
GP2  A4001 (-4.2A)
TRS  A5001 ( 4.9A)
None
 0.85A 3tl9A-1s1dA:
undetectable		 3tl9A-1s1dA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 1s1d APYRASE
(Homo
sapiens) 		4 / 7 PRO A 208
ARG A 236
GLY A 168
VAL A 170
 None
 0.94A 4a3uB-1s1dA:
undetectable		 4a3uB-1s1dA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_2
(ASPARTYL PROTEASE)		 1s1d APYRASE
(Homo
sapiens) 		5 / 10 GLY A 157
ALA A 144
ASP A 112
ILE A 101
VAL A 129
 None
None
GP2  A4001 (-4.2A)
TRS  A5001 ( 4.9A)
None
 0.87A 4dqbB-1s1dA:
undetectable		 4dqbB-1s1dA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_2
(ASPARTYL PROTEASE)		 1s1d APYRASE
(Homo
sapiens) 		5 / 10 GLY A 157
ALA A 144
ASP A 112
ILE A 101
VAL A 129
 None
None
GP2  A4001 (-4.2A)
TRS  A5001 ( 4.9A)
None
 0.86A 4dqeB-1s1dA:
undetectable		 4dqeB-1s1dA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_2
(ASPARTYL PROTEASE)		 1s1d APYRASE
(Homo
sapiens) 		5 / 10 GLY A 157
ALA A 144
ASP A 112
ILE A 101
VAL A 129
 None
None
GP2  A4001 (-4.2A)
TRS  A5001 ( 4.9A)
None
 0.89A 4dqfB-1s1dA:
undetectable		 4dqfB-1s1dA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_2
(WILD-TYPE HIV-1
PROTEASE DIMER)		 1s1d APYRASE
(Homo
sapiens) 		5 / 10 GLY A 157
ALA A 144
ASP A 112
ILE A 101
VAL A 129
 None
None
GP2  A4001 (-4.2A)
TRS  A5001 ( 4.9A)
None
 0.84A 4dqhB-1s1dA:
undetectable		 4dqhB-1s1dA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EBK_A_TOYA301_1
(AMINOGLYCOSIDE
NUCLEOTIDYLTRANSFERA
SE)		 1s1d APYRASE
(Homo
sapiens) 		5 / 9 GLU A 243
GLU A 295
GLU A 326
ASP A 112
GLU A 239
 None
None
GP2  A4001 ( 2.4A)
GP2  A4001 (-4.2A)
None
 1.40A 4ebkA-1s1dA:
0.0
4ebkB-1s1dA:
0.0		 4ebkA-1s1dA:
23.16
4ebkB-1s1dA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 1s1d APYRASE
(Homo
sapiens) 		4 / 8 SER A  98
ASP A 112
GLU A 214
THR A  45
 GP2  A4001 (-4.8A)
GP2  A4001 (-4.2A)
CA  A1001 (-4.0A)
None
 0.80A 4lnwA-1s1dA:
undetectable		 4lnwA-1s1dA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 1s1d APYRASE
(Homo
sapiens) 		4 / 6 ASP A  42
ASP A 112
GLU A 145
ARG A  93
 GP2  A4001 (-3.7A)
GP2  A4001 (-4.2A)
GP2  A4001 ( 2.7A)
None
 1.41A 4ntxA-1s1dA:
0.0
4ntxC-1s1dA:
undetectable		 4ntxA-1s1dA:
20.94
4ntxC-1s1dA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 1s1d APYRASE
(Homo
sapiens) 		4 / 6 GLU A 295
ASP A  42
ASP A 112
GLU A 145
 None
GP2  A4001 (-3.7A)
GP2  A4001 (-4.2A)
GP2  A4001 ( 2.7A)
 1.31A 4ntxA-1s1dA:
0.0
4ntxC-1s1dA:
undetectable		 4ntxA-1s1dA:
20.94
4ntxC-1s1dA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_1
(ASPARTYL PROTEASE)		 1s1d APYRASE
(Homo
sapiens) 		5 / 9 GLY A 157
ALA A 144
ASP A 112
ILE A 101
VAL A 129
 None
None
GP2  A4001 (-4.2A)
TRS  A5001 ( 4.9A)
None
 0.89A 4q1wA-1s1dA:
undetectable		 4q1wA-1s1dA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_1
(ASPARTYL PROTEASE)		 1s1d APYRASE
(Homo
sapiens) 		5 / 11 GLY A 157
ALA A 144
ASP A 112
ILE A 101
VAL A 129
 None
None
GP2  A4001 (-4.2A)
TRS  A5001 ( 4.9A)
None
 0.87A 4q1xA-1s1dA:
undetectable		 4q1xA-1s1dA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_1
(ASPARTYL PROTEASE)		 1s1d APYRASE
(Homo
sapiens) 		5 / 10 GLY A 157
ALA A 144
ASP A 112
ILE A 101
VAL A 129
 None
None
GP2  A4001 (-4.2A)
TRS  A5001 ( 4.9A)
None
 0.89A 4q1yA-1s1dA:
undetectable		 4q1yA-1s1dA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_1
(PROTEASE)		 1s1d APYRASE
(Homo
sapiens) 		5 / 11 GLY A 157
ALA A 144
ASP A 112
ILE A 101
VAL A 129
 None
None
GP2  A4001 (-4.2A)
TRS  A5001 ( 4.9A)
None
 0.94A 4qgiA-1s1dA:
undetectable		 4qgiA-1s1dA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA303_0
(THAUMATIN-1)		 1s1d APYRASE
(Homo
sapiens) 		4 / 7 LEU A 100
GLU A 329
ILE A 328
VAL A 289
 None
TRS  A5001 (-3.0A)
None
None
 1.18A 4tvtA-1s1dA:
undetectable		 4tvtA-1s1dA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 1s1d APYRASE
(Homo
sapiens) 		4 / 5 THR A 114
GLY A 141
GLU A 145
ASP A 111
 None
None
GP2  A4001 ( 2.7A)
None
 0.97A 5c0oH-1s1dA:
undetectable		 5c0oH-1s1dA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FEP_A_SAMA407_0
([FEFE] HYDROGENASE
MATURASE SUBUNIT
HYDE)		 1s1d APYRASE
(Homo
sapiens) 		5 / 12 GLY A 327
LEU A 291
ILE A  33
TYR A  21
TYR A  35
 None
None
None
TRS  A5001 (-3.4A)
None
 1.43A 5fepA-1s1dA:
undetectable		 5fepA-1s1dA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FES_A_SAMA408_0
([FEFE] HYDROGENASE
MATURASE SUBUNIT
HYDE)		 1s1d APYRASE
(Homo
sapiens) 		5 / 12 GLY A 327
LEU A 291
ILE A  33
TYR A  21
TYR A  35
 None
None
None
TRS  A5001 (-3.4A)
None
 1.48A 5fesA-1s1dA:
undetectable		 5fesA-1s1dA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_2
(PROTEASE E35D-APV)		 1s1d APYRASE
(Homo
sapiens) 		5 / 9 GLY A 157
ALA A 144
ASP A 112
ILE A 101
VAL A 129
 None
None
GP2  A4001 (-4.2A)
TRS  A5001 ( 4.9A)
None
 0.81A 5kr0B-1s1dA:
undetectable		 5kr0B-1s1dA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 1s1d APYRASE
(Homo
sapiens) 		5 / 12 PHE A 103
LEU A 100
ASP A  19
SER A 109
VAL A 110
 None
 1.09A 6mhtA-1s1dA:
undetectable		 6mhtA-1s1dA:
22.02