SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1s1f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVT_A_FLPA125_1
(TRANSTHYRETIN)		 1s1f PUTATIVE CYTOCHROME
P450
(Streptomyces
coelicolor) 		4 / 8 LEU A 104
LEU A 361
LEU A 358
THR A 113
 None
 0.93A 1dvtA-1s1fA:
undetectable
1dvtB-1s1fA:
undetectable		 1dvtA-1s1fA:
15.45
1dvtB-1s1fA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4002_1
(SERUM ALBUMIN)		 1s1f PUTATIVE CYTOCHROME
P450
(Streptomyces
coelicolor) 		4 / 4 ARG A 103
ALA A 221
ALA A 232
GLU A 231
 None
 1.08A 1e7bB-1s1fA:
0.4		 1e7bB-1s1fA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1503_0
(FERROCHELATASE)		 1s1f PUTATIVE CYTOCHROME
P450
(Streptomyces
coelicolor) 		3 / 3 LEU A  44
PRO A  45
LEU A  82
 None
 0.50A 1hrkA-1s1fA:
undetectable		 1hrkA-1s1fA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 1s1f PUTATIVE CYTOCHROME
P450
(Streptomyces
coelicolor) 		3 / 3 ALA A 245
GLY A 356
SER A 363
 PIM  A 431 (-3.6A)
None
None
 0.56A 2ivuA-1s1fA:
undetectable		 2ivuA-1s1fA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1104_0
(FERROCHELATASE)		 1s1f PUTATIVE CYTOCHROME
P450
(Streptomyces
coelicolor) 		3 / 3 LEU A  44
PRO A  45
LEU A  82
 None
 0.51A 2qd5B-1s1fA:
undetectable		 2qd5B-1s1fA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 1s1f PUTATIVE CYTOCHROME
P450
(Streptomyces
coelicolor) 		5 / 12 ASN A 248
HIS A 172
PRO A 151
THR A 145
LEU A 366
 None
 1.49A 2xrlA-1s1fA:
undetectable		 2xrlA-1s1fA:
22.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TZO_B_SPMB432_1
(PUTATIVE CYTOCHROME
P450)		 1s1f PUTATIVE CYTOCHROME
P450
(Streptomyces
coelicolor) 		4 / 4 LYS A 378
ALA A 382
THR A 403
HIS A 405
 None
 0.41A 3tzoB-1s1fA:
58.9		 3tzoB-1s1fA:
99.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_1
(MNMC2)		 1s1f PUTATIVE CYTOCHROME
P450
(Streptomyces
coelicolor) 		4 / 6 HIS A 183
GLU A 398
ASP A 143
GLU A 146
 None
 1.24A 3vywA-1s1fA:
undetectable		 3vywA-1s1fA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 1s1f PUTATIVE CYTOCHROME
P450
(Streptomyces
coelicolor) 		3 / 3 ARG A  81
PHE A  86
PRO A  88
 None
MLA  A 432 (-4.9A)
MLA  A 432 (-4.3A)
 0.77A 3zoaB-1s1fA:
undetectable		 3zoaB-1s1fA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_A_C2FA302_0
(THYMIDYLATE SYNTHASE)		 1s1f PUTATIVE CYTOCHROME
P450
(Streptomyces
coelicolor) 		5 / 11 HIS A 183
SER A 182
ILE A  87
GLY A 292
TYR A 318
 None
None
MLA  A 432 ( 3.9A)
MLA  A 433 ( 3.6A)
HEM  A 430 (-4.5A)
 1.21A 4fogA-1s1fA:
0.0		 4fogA-1s1fA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_C_C2FC302_0
(THYMIDYLATE SYNTHASE)		 1s1f PUTATIVE CYTOCHROME
P450
(Streptomyces
coelicolor) 		5 / 11 HIS A 183
SER A 182
ILE A  87
GLY A 292
TYR A 318
 None
None
MLA  A 432 ( 3.9A)
MLA  A 433 ( 3.6A)
HEM  A 430 (-4.5A)
 1.21A 4fogC-1s1fA:
0.0		 4fogC-1s1fA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_A_D16A301_1
(THYMIDYLATE SYNTHASE)		 1s1f PUTATIVE CYTOCHROME
P450
(Streptomyces
coelicolor) 		5 / 12 HIS A 183
SER A 182
ILE A  87
GLY A 292
TYR A 318
 None
None
MLA  A 432 ( 3.9A)
MLA  A 433 ( 3.6A)
HEM  A 430 (-4.5A)
 1.19A 4foxA-1s1fA:
0.0		 4foxA-1s1fA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_B_D16B302_1
(THYMIDYLATE SYNTHASE)		 1s1f PUTATIVE CYTOCHROME
P450
(Streptomyces
coelicolor) 		5 / 12 HIS A 183
SER A 182
ILE A  87
GLY A 292
TYR A 318
 None
None
MLA  A 432 ( 3.9A)
MLA  A 433 ( 3.6A)
HEM  A 430 (-4.5A)
 1.11A 4foxB-1s1fA:
0.0		 4foxB-1s1fA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 1s1f PUTATIVE CYTOCHROME
P450
(Streptomyces
coelicolor) 		5 / 12 HIS A 183
SER A 182
ILE A  87
GLY A 292
TYR A 318
 None
None
MLA  A 432 ( 3.9A)
MLA  A 433 ( 3.6A)
HEM  A 430 (-4.5A)
 1.20A 4foxE-1s1fA:
0.0		 4foxE-1s1fA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_G_D16G301_1
(THYMIDYLATE SYNTHASE)		 1s1f PUTATIVE CYTOCHROME
P450
(Streptomyces
coelicolor) 		5 / 12 HIS A 183
SER A 182
ILE A  87
GLY A 292
TYR A 318
 None
None
MLA  A 432 ( 3.9A)
MLA  A 433 ( 3.6A)
HEM  A 430 (-4.5A)
 1.21A 4foxG-1s1fA:
0.0		 4foxG-1s1fA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_H_D16H301_1
(THYMIDYLATE SYNTHASE)		 1s1f PUTATIVE CYTOCHROME
P450
(Streptomyces
coelicolor) 		5 / 11 HIS A 183
SER A 182
ILE A  87
GLY A 292
TYR A 318
 None
None
MLA  A 432 ( 3.9A)
MLA  A 433 ( 3.6A)
HEM  A 430 (-4.5A)
 1.30A 4foxH-1s1fA:
0.0		 4foxH-1s1fA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_1
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 1s1f PUTATIVE CYTOCHROME
P450
(Streptomyces
coelicolor) 		3 / 3 GLU A 280
ASP A 335
ASP A 332
 None
 0.75A 4gc9A-1s1fA:
undetectable		 4gc9A-1s1fA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1s1f PUTATIVE CYTOCHROME
P450
(Streptomyces
coelicolor) 		5 / 12 LEU A 361
GLU A 362
GLU A 265
PHE A 254
LEU A 144
 None
 1.14A 4retA-1s1fA:
undetectable		 4retA-1s1fA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1s1f PUTATIVE CYTOCHROME
P450
(Streptomyces
coelicolor) 		5 / 12 LEU A 361
GLU A 362
GLU A 265
PHE A 254
LEU A 144
 None
 1.14A 4retC-1s1fA:
undetectable		 4retC-1s1fA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_A_URFA302_1
(URIDINE
PHOSPHORYLASE)		 1s1f PUTATIVE CYTOCHROME
P450
(Streptomyces
coelicolor) 		4 / 7 GLY A 219
MET A 161
ALA A 221
ILE A 227
 None
 0.86A 4txnA-1s1fA:
undetectable		 4txnA-1s1fA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_B_URFB302_1
(URIDINE
PHOSPHORYLASE)		 1s1f PUTATIVE CYTOCHROME
P450
(Streptomyces
coelicolor) 		4 / 7 GLY A 219
MET A 161
ALA A 221
ILE A 227
 None
 0.88A 4txnB-1s1fA:
undetectable		 4txnB-1s1fA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_C_URFC302_1
(URIDINE
PHOSPHORYLASE)		 1s1f PUTATIVE CYTOCHROME
P450
(Streptomyces
coelicolor) 		4 / 7 GLY A 219
MET A 161
ALA A 221
ILE A 227
 None
 0.88A 4txnC-1s1fA:
undetectable		 4txnC-1s1fA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_D_URFD302_1
(URIDINE
PHOSPHORYLASE)		 1s1f PUTATIVE CYTOCHROME
P450
(Streptomyces
coelicolor) 		4 / 7 GLY A 219
MET A 161
ALA A 221
ILE A 227
 None
 0.87A 4txnD-1s1fA:
undetectable		 4txnD-1s1fA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_B_DIFB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1s1f PUTATIVE CYTOCHROME
P450
(Streptomyces
coelicolor) 		4 / 8 ILE A 285
SER A 259
LEU A 400
LEU A 144
 None
 0.95A 4xtaB-1s1fA:
undetectable		 4xtaB-1s1fA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1s1f PUTATIVE CYTOCHROME
P450
(Streptomyces
coelicolor) 		3 / 3 ASP A 332
LEU A  21
ARG A 395
 None
 0.90A 5e8qA-1s1fA:
undetectable		 5e8qA-1s1fA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 1s1f PUTATIVE CYTOCHROME
P450
(Streptomyces
coelicolor) 		6 / 12 GLY A 251
LEU A 257
THR A 145
VAL A 148
VAL A 367
LEU A 366
 None
 1.28A 5kpcA-1s1fA:
undetectable		 5kpcA-1s1fA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1s1f PUTATIVE CYTOCHROME
P450
(Streptomyces
coelicolor) 		5 / 7 GLY A 355
LEU A 358
ILE A 157
GLY A 243
ILE A 203
 HEM  A 430 (-3.6A)
None
HG  A 436 (-4.7A)
HEM  A 430 (-3.3A)
None
 1.00A 5vkqA-1s1fA:
undetectable
5vkqB-1s1fA:
undetectable		 5vkqA-1s1fA:
13.22
5vkqB-1s1fA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1s1f PUTATIVE CYTOCHROME
P450
(Streptomyces
coelicolor) 		5 / 8 GLY A 355
LEU A 358
ILE A 157
GLY A 243
ILE A 203
 HEM  A 430 (-3.6A)
None
HG  A 436 (-4.7A)
HEM  A 430 (-3.3A)
None
 0.99A 5vkqB-1s1fA:
1.2
5vkqC-1s1fA:
undetectable		 5vkqB-1s1fA:
13.22
5vkqC-1s1fA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1s1f PUTATIVE CYTOCHROME
P450
(Streptomyces
coelicolor) 		5 / 9 GLY A 355
LEU A 358
ILE A 157
GLY A 243
ILE A 203
 HEM  A 430 (-3.6A)
None
HG  A 436 (-4.7A)
HEM  A 430 (-3.3A)
None
 0.95A 5vkqC-1s1fA:
1.2
5vkqD-1s1fA:
undetectable		 5vkqC-1s1fA:
13.22
5vkqD-1s1fA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPL_B_PA1B605_1
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 1s1f PUTATIVE CYTOCHROME
P450
(Streptomyces
coelicolor) 		3 / 3 ARG A 266
ARG A 333
ARG A 276
 None
 0.92A 6bplA-1s1fA:
undetectable
6bplB-1s1fA:
undetectable		 6bplA-1s1fA:
12.28
6bplB-1s1fA:
12.28