SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1s1g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_D_TFPD207_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1s1g POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY D
MEMBER 3
(Homo
sapiens) 		4 / 8 LEU A  44
PHE A  84
PHE A 120
SER A  68
 None
 0.98A 1wrlC-1s1gA:
undetectable
1wrlD-1s1gA:
undetectable		 1wrlC-1s1gA:
18.55
1wrlD-1s1gA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_C_VIBC223_1
(THIAMINE
PYROPHOSPHOKINASE)		 1s1g POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY D
MEMBER 3
(Homo
sapiens) 		4 / 8 ASP A 115
TYR A 105
LEU A 103
LEU A 118
 None
 0.96A 3lm8A-1s1gA:
undetectable
3lm8C-1s1gA:
undetectable		 3lm8A-1s1gA:
18.61
3lm8C-1s1gA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BC9_A_ETSA302_2
(CARBONIC ANHYDRASE 2)		 1s1g POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY D
MEMBER 3
(Homo
sapiens) 		4 / 5 HIS A 104
GLU A  89
LEU A  44
VAL A  46
 ZN  A 152 (-3.3A)
None
None
None
 1.10A 6bc9A-1s1gA:
undetectable		 6bc9A-1s1gA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_N_PCFN606_0
(CYTOCHROME B)		 1s1g POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY D
MEMBER 3
(Homo
sapiens) 		5 / 12 PHE A 120
TYR A  61
PHE A  97
VAL A  94
VAL A  90
 None
 1.26A 6hu9N-1s1gA:
undetectable		 6hu9N-1s1gA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_B_LLLB301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1s1g POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY D
MEMBER 3
(Homo
sapiens) 		4 / 7 ARG A 141
GLU A 142
ASP A 138
GLU A 134
 None
 1.03A 6mn5B-1s1gA:
undetectable		 6mn5B-1s1gA:
19.20