SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1s2n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_U_9CRU502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
1s2n EXTRACELLULAR
SUBTILISIN-LIKE
SERINE PROTEINASE

(Vibrio
sp.
PA-44)
5 / 12 ALA A 231
ALA A 230
ALA A  86
VAL A 115
ILE A  36
None
1.00A 1fm6U-1s2nA:
undetectable
1fm6U-1s2nA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_A_VIBA502_1
(THIAMIN
PYROPHOSPHOKINASE)
1s2n EXTRACELLULAR
SUBTILISIN-LIKE
SERINE PROTEINASE

(Vibrio
sp.
PA-44)
4 / 8 SER A 158
ASN A 159
ASP A 161
THR A 165
None
1.02A 1ig3A-1s2nA:
2.6
1ig3B-1s2nA:
2.6
1ig3A-1s2nA:
19.56
1ig3B-1s2nA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))
1s2n EXTRACELLULAR
SUBTILISIN-LIKE
SERINE PROTEINASE

(Vibrio
sp.
PA-44)
4 / 4 HIS A 225
ALA A 199
PHE A 198
GLY A 201
None
1.19A 1mj2B-1s2nA:
undetectable
1mj2B-1s2nA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))
1s2n EXTRACELLULAR
SUBTILISIN-LIKE
SERINE PROTEINASE

(Vibrio
sp.
PA-44)
4 / 4 HIS A 225
ALA A 199
PHE A 198
GLY A 201
None
1.22A 1mj2D-1s2nA:
undetectable
1mj2D-1s2nA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)
1s2n EXTRACELLULAR
SUBTILISIN-LIKE
SERINE PROTEINASE

(Vibrio
sp.
PA-44)
4 / 4 HIS A 225
ALA A 199
PHE A 198
GLY A 201
None
1.18A 1mjoB-1s2nA:
undetectable
1mjoB-1s2nA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)
1s2n EXTRACELLULAR
SUBTILISIN-LIKE
SERINE PROTEINASE

(Vibrio
sp.
PA-44)
4 / 4 HIS A 225
ALA A 199
PHE A 198
GLY A 201
None
1.13A 1mjoA-1s2nA:
undetectable
1mjoA-1s2nA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)
1s2n EXTRACELLULAR
SUBTILISIN-LIKE
SERINE PROTEINASE

(Vibrio
sp.
PA-44)
4 / 4 HIS A 225
ALA A 199
PHE A 198
GLY A 201
None
1.19A 1mjoD-1s2nA:
undetectable
1mjoD-1s2nA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)
1s2n EXTRACELLULAR
SUBTILISIN-LIKE
SERINE PROTEINASE

(Vibrio
sp.
PA-44)
3 / 3 HIS A 225
ILE A  78
LEU A 232
None
0.71A 2kceA-1s2nA:
undetectable
2kceA-1s2nA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_1
(PROTEASE)
1s2n EXTRACELLULAR
SUBTILISIN-LIKE
SERINE PROTEINASE

(Vibrio
sp.
PA-44)
5 / 12 LEU A 197
ALA A 222
ILE A  78
VAL A 174
VAL A 176
None
0.99A 2nnkA-1s2nA:
undetectable
2nnkA-1s2nA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)
1s2n EXTRACELLULAR
SUBTILISIN-LIKE
SERINE PROTEINASE

(Vibrio
sp.
PA-44)
5 / 10 VAL A  31
GLY A  30
GLY A  79
LEU A 232
ALA A 231
None
1.00A 2v3kA-1s2nA:
undetectable
2v3kA-1s2nA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)
1s2n EXTRACELLULAR
SUBTILISIN-LIKE
SERINE PROTEINASE

(Vibrio
sp.
PA-44)
5 / 9 ALA A   4
TYR A  22
GLY A  84
GLY A   7
ILE A  11
None
1.31A 2v7bA-1s2nA:
2.5
2v7bA-1s2nA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)
1s2n EXTRACELLULAR
SUBTILISIN-LIKE
SERINE PROTEINASE

(Vibrio
sp.
PA-44)
3 / 3 SER A 220
GLY A 156
GLY A 130
PMS  A1284 (-2.1A)
PMS  A1284 (-3.5A)
PMS  A1284 (-3.3A)
0.57A 3bogA-1s2nA:
undetectable
3bogC-1s2nA:
undetectable
3bogA-1s2nA:
undetectable
3bogC-1s2nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMT_C_CCSC166_0
(GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL)
1s2n EXTRACELLULAR
SUBTILISIN-LIKE
SERINE PROTEINASE

(Vibrio
sp.
PA-44)
4 / 8 SER A 206
THR A  77
HIS A 225
TYR A  83
None
1.02A 3dmtC-1s2nA:
4.1
3dmtC-1s2nA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E00_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
1s2n EXTRACELLULAR
SUBTILISIN-LIKE
SERINE PROTEINASE

(Vibrio
sp.
PA-44)
5 / 12 ALA A 231
ALA A 230
ALA A  86
VAL A 115
ILE A  36
None
1.00A 3e00A-1s2nA:
undetectable
3e00A-1s2nA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)
1s2n EXTRACELLULAR
SUBTILISIN-LIKE
SERINE PROTEINASE

(Vibrio
sp.
PA-44)
5 / 10 LEU A 129
ILE A  36
SER A 110
SER A 106
GLY A 111
None
1.41A 3iluB-1s2nA:
undetectable
3iluE-1s2nA:
undetectable
3iluB-1s2nA:
21.52
3iluE-1s2nA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_A_VIBA223_1
(THIAMINE
PYROPHOSPHOKINASE)
1s2n EXTRACELLULAR
SUBTILISIN-LIKE
SERINE PROTEINASE

(Vibrio
sp.
PA-44)
4 / 7 SER A 158
ASN A 159
ASP A 161
THR A 165
None
0.97A 3lm8A-1s2nA:
2.4
3lm8C-1s2nA:
2.4
3lm8A-1s2nA:
20.00
3lm8C-1s2nA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)
1s2n EXTRACELLULAR
SUBTILISIN-LIKE
SERINE PROTEINASE

(Vibrio
sp.
PA-44)
5 / 12 ALA A 136
LEU A 137
VAL A 141
LEU A 129
ALA A 125
None
1.02A 3ozuA-1s2nA:
2.2
3ozuA-1s2nA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD5_A_GEOA501_1
(NUPC FAMILY PROTEIN)
1s2n EXTRACELLULAR
SUBTILISIN-LIKE
SERINE PROTEINASE

(Vibrio
sp.
PA-44)
5 / 12 GLY A  76
ALA A  75
VAL A  40
ASN A  43
PHE A  47
None
1.12A 4pd5A-1s2nA:
undetectable
4pd5A-1s2nA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)
1s2n EXTRACELLULAR
SUBTILISIN-LIKE
SERINE PROTEINASE

(Vibrio
sp.
PA-44)
4 / 7 LEU A 129
THR A 175
ALA A 154
THR A 219
None
None
PMS  A1284 ( 3.8A)
PMS  A1284 (-4.6A)
1.04A 4pwjB-1s2nA:
undetectable
4pwjB-1s2nA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)
1s2n EXTRACELLULAR
SUBTILISIN-LIKE
SERINE PROTEINASE

(Vibrio
sp.
PA-44)
4 / 8 SER A 189
THR A 179
SER A 202
ASP A 183
None
1.37A 4qb9D-1s2nA:
undetectable
4qb9D-1s2nA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT7_A_TOPA302_1
(RV2671)
1s2n EXTRACELLULAR
SUBTILISIN-LIKE
SERINE PROTEINASE

(Vibrio
sp.
PA-44)
5 / 11 ILE A 109
THR A 104
SER A 106
GLY A 107
ASP A 113
None
1.32A 4xt7A-1s2nA:
undetectable
4xt7A-1s2nA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)
1s2n EXTRACELLULAR
SUBTILISIN-LIKE
SERINE PROTEINASE

(Vibrio
sp.
PA-44)
4 / 7 LEU A 129
THR A 175
ALA A 154
THR A 219
None
None
PMS  A1284 ( 3.8A)
PMS  A1284 (-4.6A)
1.01A 5bojB-1s2nA:
undetectable
5bojB-1s2nA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_A_ILEA601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)
1s2n EXTRACELLULAR
SUBTILISIN-LIKE
SERINE PROTEINASE

(Vibrio
sp.
PA-44)
4 / 6 ALA A 222
THR A 223
VAL A 226
VAL A 195
None
0.99A 5eckA-1s2nA:
undetectable
5eckA-1s2nA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_D_ILED601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)
1s2n EXTRACELLULAR
SUBTILISIN-LIKE
SERINE PROTEINASE

(Vibrio
sp.
PA-44)
4 / 6 ALA A 222
THR A 223
VAL A 226
VAL A 195
None
1.04A 5eckD-1s2nA:
undetectable
5eckD-1s2nA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_A_ILEA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)
1s2n EXTRACELLULAR
SUBTILISIN-LIKE
SERINE PROTEINASE

(Vibrio
sp.
PA-44)
4 / 6 ALA A 222
THR A 223
VAL A 226
VAL A 195
None
0.91A 5eclA-1s2nA:
undetectable
5eclA-1s2nA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_D_ILED602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)
1s2n EXTRACELLULAR
SUBTILISIN-LIKE
SERINE PROTEINASE

(Vibrio
sp.
PA-44)
4 / 6 ALA A 222
THR A 223
VAL A 226
VAL A 195
None
0.77A 5eclD-1s2nA:
undetectable
5eclD-1s2nA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
1s2n EXTRACELLULAR
SUBTILISIN-LIKE
SERINE PROTEINASE

(Vibrio
sp.
PA-44)
4 / 4 ALA A 207
PRO A 224
LEU A 129
HIS A  70
None
None
None
PMS  A1284 (-4.1A)
1.29A 5eskA-1s2nA:
undetectable
5eskA-1s2nA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)
1s2n EXTRACELLULAR
SUBTILISIN-LIKE
SERINE PROTEINASE

(Vibrio
sp.
PA-44)
4 / 8 TYR A 233
LEU A 269
LEU A 197
THR A 265
None
1.12A 5hs6A-1s2nA:
4.4
5hs6A-1s2nA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_1
(CDL2.2)
1s2n EXTRACELLULAR
SUBTILISIN-LIKE
SERINE PROTEINASE

(Vibrio
sp.
PA-44)
5 / 10 TYR A  22
VAL A  31
ILE A  78
PRO A 122
LEU A   8
None
1.00A 5ienB-1s2nA:
undetectable
5ienB-1s2nA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)
1s2n EXTRACELLULAR
SUBTILISIN-LIKE
SERINE PROTEINASE

(Vibrio
sp.
PA-44)
5 / 12 HIS A  73
GLY A  71
HIS A 225
ALA A 227
SER A 189
None
1.09A 5igyA-1s2nA:
undetectable
5igyA-1s2nA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)
1s2n EXTRACELLULAR
SUBTILISIN-LIKE
SERINE PROTEINASE

(Vibrio
sp.
PA-44)
3 / 3 LYS A  87
GLN A  13
ASN A  23
None
CA  A1292 (-3.4A)
None
1.03A 5l2tA-1s2nA:
undetectable
5l2tA-1s2nA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_1
(ALPHA-AMYLASE)
1s2n EXTRACELLULAR
SUBTILISIN-LIKE
SERINE PROTEINASE

(Vibrio
sp.
PA-44)
3 / 3 TYR A  34
ALA A 230
LEU A 234
None
0.60A 6ag0C-1s2nA:
2.5
6ag0C-1s2nA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)
1s2n EXTRACELLULAR
SUBTILISIN-LIKE
SERINE PROTEINASE

(Vibrio
sp.
PA-44)
5 / 12 VAL A 170
ASP A 196
LEU A 197
THR A 246
LEU A 249
None
CA  A1290 (-2.2A)
None
None
None
1.21A 6b54A-1s2nA:
undetectable
6b54A-1s2nA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)
1s2n EXTRACELLULAR
SUBTILISIN-LIKE
SERINE PROTEINASE

(Vibrio
sp.
PA-44)
4 / 5 TYR A  22
LYS A  87
GLN A   1
ILE A  11
None
1.42A 6debB-1s2nA:
3.4
6debB-1s2nA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)
1s2n EXTRACELLULAR
SUBTILISIN-LIKE
SERINE PROTEINASE

(Vibrio
sp.
PA-44)
5 / 12 GLU A  46
GLY A  79
TYR A 213
PRO A 224
GLY A 228
None
1.02A 6gngA-1s2nA:
4.0
6gngA-1s2nA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)
1s2n EXTRACELLULAR
SUBTILISIN-LIKE
SERINE PROTEINASE

(Vibrio
sp.
PA-44)
5 / 12 GLU A  46
GLY A  79
TYR A 213
VAL A  35
PRO A 224
None
1.20A 6gngA-1s2nA:
4.0
6gngA-1s2nA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)
1s2n EXTRACELLULAR
SUBTILISIN-LIKE
SERINE PROTEINASE

(Vibrio
sp.
PA-44)
5 / 12 GLU A  46
GLY A  84
TYR A 213
PRO A 224
GLY A 228
None
1.42A 6gngA-1s2nA:
4.0
6gngA-1s2nA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)
1s2n EXTRACELLULAR
SUBTILISIN-LIKE
SERINE PROTEINASE

(Vibrio
sp.
PA-44)
4 / 8 GLY A 121
VAL A 115
GLY A  28
ALA A 230
None
0.79A 6hu9H-1s2nA:
undetectable
6hu9e-1s2nA:
undetectable
6hu9H-1s2nA:
18.99
6hu9e-1s2nA:
17.50