SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1s2t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_1
(PROTEIN (HIV-1
PROTEASE))		 1s2t PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE
(Mytilus
edulis) 		5 / 10 LEU A  71
ALA A  32
GLY A  42
ILE A  23
VAL A 108
 None
 0.85A 1d4yA-1s2tA:
undetectable		 1d4yA-1s2tA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_2
(HIV-1 PROTEASE)		 1s2t PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE
(Mytilus
edulis) 		5 / 11 LEU A  71
ALA A  32
GLY A  42
ILE A  23
VAL A 108
 None
 0.77A 1hxwB-1s2tA:
undetectable		 1hxwB-1s2tA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_1
(PROTEASE RETROPEPSIN)		 1s2t PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE
(Mytilus
edulis) 		5 / 10 LEU A  71
ALA A  32
GLY A  42
ILE A  23
VAL A 108
 None
 0.85A 1t3rA-1s2tA:
undetectable		 1t3rA-1s2tA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_1
(PROTEASE)		 1s2t PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE
(Mytilus
edulis) 		5 / 12 LEU A  71
ALA A  32
GLY A  42
ILE A  23
VAL A 108
 None
 0.88A 2ienA-1s2tA:
undetectable		 2ienA-1s2tA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_1
(PROTEASE)		 1s2t PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE
(Mytilus
edulis) 		5 / 12 LEU A  71
ALA A  32
GLY A  42
ILE A  23
VAL A 108
 None
 0.90A 2ieoA-1s2tA:
undetectable		 2ieoA-1s2tA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		 1s2t PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE
(Mytilus
edulis) 		4 / 6 ASP A  87
SER A  51
LEU A  48
GLY A  47
 None
 0.95A 2j2pA-1s2tA:
undetectable
2j2pC-1s2tA:
0.0		 2j2pA-1s2tA:
20.72
2j2pC-1s2tA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		 1s2t PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE
(Mytilus
edulis) 		4 / 6 ASP A  87
SER A  51
LEU A  48
GLY A  47
 None
 0.98A 2j2pD-1s2tA:
undetectable
2j2pF-1s2tA:
undetectable		 2j2pD-1s2tA:
20.72
2j2pF-1s2tA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_2
(PROTEASE)		 1s2t PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE
(Mytilus
edulis) 		5 / 11 LEU A  71
ALA A  32
GLY A  42
ILE A  23
VAL A 108
 None
 0.74A 2nnpB-1s2tA:
undetectable		 2nnpB-1s2tA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_2
(PROTEASE)		 1s2t PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE
(Mytilus
edulis) 		4 / 8 LEU A  71
ALA A  32
GLY A  42
ILE A  23
 None
 0.68A 2o4nB-1s2tA:
undetectable		 2o4nB-1s2tA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_1
(PROTEASE)		 1s2t PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE
(Mytilus
edulis) 		5 / 11 LEU A  71
ALA A  32
GLY A  42
ILE A  23
VAL A 108
 None
 0.87A 2o4pA-1s2tA:
undetectable		 2o4pA-1s2tA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_2
(PROTEASE)		 1s2t PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE
(Mytilus
edulis) 		5 / 9 LEU A  71
ALA A  32
GLY A  42
ILE A  23
VAL A 108
 None
 0.79A 2o4pB-1s2tA:
undetectable		 2o4pB-1s2tA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 1s2t PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE
(Mytilus
edulis) 		5 / 12 LEU A  71
ALA A  32
GLY A  42
ILE A  23
VAL A 108
 None
 0.85A 2q63A-1s2tA:
undetectable		 2q63A-1s2tA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 1s2t PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE
(Mytilus
edulis) 		5 / 12 PHE A 202
VAL A 160
ALA A 158
GLU A 177
ILE A 135
 None
 1.22A 3dl9A-1s2tA:
undetectable		 3dl9A-1s2tA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)		 1s2t PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE
(Mytilus
edulis) 		5 / 12 PHE A 202
VAL A 160
ALA A 158
GLU A 177
ILE A 135
 None
 1.20A 3dl9B-1s2tA:
undetectable		 3dl9B-1s2tA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)		 1s2t PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE
(Mytilus
edulis) 		3 / 3 MET A 234
CYH A 155
PRO A  81
 None
 1.20A 3h52C-1s2tA:
undetectable		 3h52C-1s2tA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW2_A_017A401_1
(GAG-POL POLYPROTEIN)		 1s2t PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE
(Mytilus
edulis) 		5 / 12 LEU A  71
ALA A  32
GLY A  42
ILE A  23
VAL A 108
 None
 0.89A 3jw2A-1s2tA:
undetectable		 3jw2A-1s2tA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW2_A_017A401_2
(GAG-POL POLYPROTEIN)		 1s2t PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE
(Mytilus
edulis) 		5 / 12 LEU A  71
ALA A  32
GLY A  42
ILE A  23
VAL A 108
 None
 0.82A 3jw2B-1s2tA:
undetectable		 3jw2B-1s2tA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_2
(HIV-1 PROTEASE)		 1s2t PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE
(Mytilus
edulis) 		5 / 12 LEU A  71
ALA A  32
GLY A  42
ILE A  23
VAL A 108
 None
 0.88A 3lzuB-1s2tA:
undetectable		 3lzuB-1s2tA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_1
(HIV-1 PROTEASE)		 1s2t PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE
(Mytilus
edulis) 		5 / 10 LEU A  71
ALA A  32
GLY A  42
ILE A  23
VAL A 108
 None
 0.87A 3lzvA-1s2tA:
undetectable		 3lzvA-1s2tA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OY4_B_017B200_2
(HIV-1 PROTEASE)		 1s2t PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE
(Mytilus
edulis) 		5 / 10 LEU A  71
ALA A  32
GLY A  42
ILE A  23
VAL A 108
 None
 0.88A 3oy4B-1s2tA:
undetectable		 3oy4B-1s2tA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_0
(2'-O-METHYL
TRANSFERASE)		 1s2t PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE
(Mytilus
edulis) 		5 / 12 GLY A  45
GLY A  42
LEU A  48
ASN A 239
ASP A  58
 None
 1.44A 3r24A-1s2tA:
undetectable		 3r24A-1s2tA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)		 1s2t PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE
(Mytilus
edulis) 		4 / 7 LEU A  71
ALA A  32
GLY A  42
ILE A  23
 None
 0.87A 3spkB-1s2tA:
undetectable		 3spkB-1s2tA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKW_B_017B401_2
(PROTEASE)		 1s2t PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE
(Mytilus
edulis) 		5 / 12 LEU A  71
ALA A  32
GLY A  42
ILE A  23
VAL A 108
 None
 0.83A 3tkwB-1s2tA:
undetectable		 3tkwB-1s2tA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_3
(PROTEASE)		 1s2t PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE
(Mytilus
edulis) 		5 / 12 LEU A  71
ALA A  32
GLY A  42
ILE A  23
VAL A 108
 None
 0.84A 3tl9B-1s2tA:
undetectable		 3tl9B-1s2tA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_2
(ASPARTYL PROTEASE)		 1s2t PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE
(Mytilus
edulis) 		5 / 10 LEU A  71
ALA A  32
GLY A  42
ILE A  23
VAL A 108
 None
 0.78A 4dqbB-1s2tA:
undetectable		 4dqbB-1s2tA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_2
(ASPARTYL PROTEASE)		 1s2t PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE
(Mytilus
edulis) 		5 / 10 LEU A  71
ALA A  32
GLY A  42
ILE A  23
VAL A 108
 None
 0.77A 4dqeB-1s2tA:
undetectable		 4dqeB-1s2tA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_1
(ASPARTYL PROTEASE)		 1s2t PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE
(Mytilus
edulis) 		5 / 11 LEU A  71
ALA A  32
GLY A  42
ILE A  23
VAL A 108
 None
 0.90A 4q1xA-1s2tA:
undetectable		 4q1xA-1s2tA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_1
(ASPARTYL PROTEASE)		 1s2t PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE
(Mytilus
edulis) 		5 / 10 LEU A  71
ALA A  32
GLY A  42
ILE A  23
VAL A 108
 None
 0.89A 4q1yA-1s2tA:
undetectable		 4q1yA-1s2tA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		 1s2t PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE
(Mytilus
edulis) 		4 / 7 VAL A  70
GLN A  53
SER A  46
GLU A  25
 None
 1.02A 4zphA-1s2tA:
undetectable
4zphB-1s2tA:
undetectable		 4zphA-1s2tA:
21.64
4zphB-1s2tA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_2
(PROTEASE E35D-APV)		 1s2t PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE
(Mytilus
edulis) 		5 / 9 LEU A  71
ALA A  32
GLY A  42
ILE A  23
VAL A 108
 None
 0.89A 5kr0B-1s2tA:
undetectable		 5kr0B-1s2tA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUN_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 1s2t PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE
(Mytilus
edulis) 		5 / 9 ALA A 111
VAL A 157
ILE A 236
ILE A  23
ALA A  86
 None
 0.92A 5nunA-1s2tA:
0.0		 5nunA-1s2tA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_0
(HIV-1 PROTEASE)		 1s2t PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE
(Mytilus
edulis) 		5 / 12 LEU A  71
ALA A  32
GLY A  42
ILE A  23
VAL A 108
 None
 0.83A 6dilA-1s2tA:
undetectable		 6dilA-1s2tA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_1
(HIV-1 PROTEASE)		 1s2t PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE
(Mytilus
edulis) 		5 / 12 LEU A  71
ALA A  32
GLY A  42
ILE A  23
VAL A 108
 None
 0.85A 6dilB-1s2tA:
undetectable		 6dilB-1s2tA:
18.92