SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1s2x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_A_FLPA1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1s2x CAG-Z
(Helicobacter
pylori) 		5 / 12 VAL A  52
LEU A  49
LEU A  39
GLY A 146
LEU A 131
 None
 1.11A 2aylA-1s2xA:
undetectable		 2aylA-1s2xA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1s2x CAG-Z
(Helicobacter
pylori) 		4 / 9 TYR A 172
ILE A 168
ILE A 164
LEU A 161
 None
 0.74A 5vkqB-1s2xA:
2.4
5vkqC-1s2xA:
2.3		 5vkqB-1s2xA:
7.87
5vkqC-1s2xA:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA504_1
(CYTOCHROME P450 2C9)		 1s2x CAG-Z
(Helicobacter
pylori) 		4 / 8 PHE A  31
ILE A  32
ASN A  58
PRO A 137
 None
 1.11A 5x23A-1s2xA:
undetectable		 5x23A-1s2xA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 1s2x CAG-Z
(Helicobacter
pylori) 		4 / 7 PHE A 112
ALA A 106
GLY A   4
ASN A 178
 None
 0.78A 5ybbB-1s2xA:
undetectable		 5ybbB-1s2xA:
17.98