SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1s35'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 1s35 SPECTRIN BETA CHAIN,
ERYTHROCYTE
(Homo
sapiens) 		4 / 8 ALA A1152
GLY A1149
THR A1148
GLN A1081
 None
 0.94A 3rglA-1s35A:
2.6		 3rglA-1s35A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_1
(METHYLTRANSFERASE
NSUN4)		 1s35 SPECTRIN BETA CHAIN,
ERYTHROCYTE
(Homo
sapiens) 		3 / 3 ASP A1222
ARG A1221
ASP A1229
 None
SO4  A 300 (-2.9A)
None
 0.83A 4fp9D-1s35A:
undetectable		 4fp9D-1s35A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		 1s35 SPECTRIN BETA CHAIN,
ERYTHROCYTE
(Homo
sapiens) 		5 / 12 LEU A1153
VAL A1084
LEU A1100
ILE A1106
ILE A1110
 None
SO4  A 301 ( 4.6A)
None
None
None
 0.87A 4ltwA-1s35A:
undetectable		 4ltwA-1s35A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_2
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 1s35 SPECTRIN BETA CHAIN,
ERYTHROCYTE
(Homo
sapiens) 		3 / 3 LEU A1251
LEU A1225
ASN A1259
 None
 0.75A 4otwA-1s35A:
undetectable		 4otwA-1s35A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_B_BEZB306_0
(BETA-LACTAMASE VIM-2)		 1s35 SPECTRIN BETA CHAIN,
ERYTHROCYTE
(Homo
sapiens) 		3 / 3 HIS A1256
ASN A1259
ALA A1263
 SO4  A 300 (-4.2A)
None
None
 0.37A 5n4tB-1s35A:
undetectable		 5n4tB-1s35A:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 1s35 SPECTRIN BETA CHAIN,
ERYTHROCYTE
(Homo
sapiens) 		4 / 6 TYR A1117
ASP A1071
LEU A1070
PHE A1073
 None
 1.03A 5nooC-1s35A:
undetectable		 5nooC-1s35A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 1s35 SPECTRIN BETA CHAIN,
ERYTHROCYTE
(Homo
sapiens) 		3 / 3 HIS A1113
GLU A1109
TRP A1076
 None
 1.16A 5odqD-1s35A:
undetectable		 5odqD-1s35A:
20.26