SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1s3d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1s3d ARSENATE REDUCTASE
(Escherichia
coli) 		4 / 6 VAL A  55
ILE A  92
ILE A  48
ASP A  83
 None
 0.72A 1uwhB-1s3dA:
undetectable		 1uwhB-1s3dA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_B_VD3B2001_1
(VITAMIN D
HYDROXYLASE)		 1s3d ARSENATE REDUCTASE
(Escherichia
coli) 		5 / 11 ILE A  92
LEU A  58
ILE A  48
THR A 103
PRO A  39
 None
 1.17A 3a50B-1s3dA:
undetectable		 3a50B-1s3dA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_A_VDYA6178_1
(VITAMIN D
HYDROXYLASE)		 1s3d ARSENATE REDUCTASE
(Escherichia
coli) 		5 / 11 ILE A  92
LEU A  58
ILE A  48
THR A 103
PRO A  39
 None
 1.17A 3a51A-1s3dA:
undetectable		 3a51A-1s3dA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)		 1s3d ARSENATE REDUCTASE
(Escherichia
coli) 		5 / 12 ILE A  92
LEU A  58
ILE A  48
THR A 103
PRO A  39
 None
 1.16A 3a51D-1s3dA:
undetectable		 3a51D-1s3dA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAU_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1s3d ARSENATE REDUCTASE
(Escherichia
coli) 		5 / 12 ILE A  53
LEU A  59
ALA A  60
ILE A  82
LEU A  44
 None
 0.99A 3dauA-1s3dA:
undetectable		 3dauA-1s3dA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		 1s3d ARSENATE REDUCTASE
(Escherichia
coli) 		4 / 6 GLU A 130
ARG A 139
GLU A 110
SER A 109
 SO4  A 203 ( 4.7A)
None
None
SO4  A 203 (-3.0A)
 1.42A 4kr3A-1s3dA:
undetectable		 4kr3A-1s3dA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSS_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1s3d ARSENATE REDUCTASE
(Escherichia
coli) 		6 / 12 ILE A  53
LEU A  59
ALA A  60
ILE A  82
LEU A  44
ILE A  48
 None
 1.15A 4pssA-1s3dA:
undetectable		 4pssA-1s3dA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSY_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1s3d ARSENATE REDUCTASE
(Escherichia
coli) 		5 / 12 ILE A  53
LEU A  59
ALA A  60
ILE A  82
LEU A  44
 None
 1.02A 4psyA-1s3dA:
undetectable		 4psyA-1s3dA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		 1s3d ARSENATE REDUCTASE
(Escherichia
coli) 		4 / 6 THR A  99
LEU A 101
THR A  27
LEU A 113
 None
 1.08A 6mvxA-1s3dA:
undetectable
6mvxB-1s3dA:
undetectable
6mvxC-1s3dA:
undetectable		 6mvxA-1s3dA:
21.51
6mvxB-1s3dA:
21.51
6mvxC-1s3dA:
21.51