SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1s3g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_4
(HIV-1 PROTEASE)		 1s3g ADENYLATE KINASE
(Sporosarcina
globispora) 		4 / 4 GLY A  32
ASP A  84
GLY A   7
THR A  89
 AP5  A 218 (-3.6A)
AP5  A 218 ( 4.7A)
None
None
 1.00A 1hxbB-1s3gA:
undetectable		 1hxbB-1s3gA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1s3g ADENYLATE KINASE
(Sporosarcina
globispora) 		4 / 7 ILE A 107
ILE A 195
LEU A  96
LEU A 183
 None
 0.93A 3adxA-1s3gA:
undetectable		 3adxA-1s3gA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_0
(REPRESSOR PROTEIN
MPHR(A))		 1s3g ADENYLATE KINASE
(Sporosarcina
globispora) 		5 / 12 THR A  89
VAL A  63
MET A  53
SER A  30
ILE A  39
 None
None
AP5  A 218 (-4.2A)
AP5  A 218 ( 4.7A)
None
 1.37A 3frqA-1s3gA:
undetectable		 3frqA-1s3gA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_2
(HIV-1 PROTEASE)		 1s3g ADENYLATE KINASE
(Sporosarcina
globispora) 		4 / 4 GLY A  32
ASP A  84
GLY A   7
THR A  89
 AP5  A 218 (-3.6A)
AP5  A 218 ( 4.7A)
None
None
 0.98A 3k4vC-1s3gA:
undetectable		 3k4vC-1s3gA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1s3g ADENYLATE KINASE
(Sporosarcina
globispora) 		5 / 12 ASP A  18
ASP A  33
ASP A  84
SER A 136
ARG A 123
 None
None
AP5  A 218 ( 4.7A)
AP5  A 218 (-2.8A)
AP5  A 218 (-3.6A)
 1.46A 4fewC-1s3gA:
0.0
4fewD-1s3gA:
0.0
4fewF-1s3gA:
0.0		 4fewC-1s3gA:
22.76
4fewD-1s3gA:
22.76
4fewF-1s3gA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR4_C_AICC401_1
(OUTER MEMBRANE
PROTEIN F)		 1s3g ADENYLATE KINASE
(Sporosarcina
globispora) 		4 / 8 ARG A 127
ARG A 160
ASP A  84
ARG A  36
 AP5  A 218 (-2.6A)
AP5  A 218 (-3.2A)
AP5  A 218 ( 4.7A)
AP5  A 218 (-2.5A)
 1.39A 4kr4C-1s3gA:
undetectable		 4kr4C-1s3gA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1s3g ADENYLATE KINASE
(Sporosarcina
globispora) 		3 / 3 ASP A  54
LYS A  48
LEU A  45
 None
 0.96A 4ptjA-1s3gA:
3.0		 4ptjA-1s3gA:
22.71