SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1s3i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_D_FUAD705_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1s3i 10-FORMYLTETRAHYDROF
OLATE DEHYDROGENASE
(Rattus
norvegicus) 		5 / 12 PHE A 280
PHE A 244
LEU A 277
VAL A 272
ALA A 260
 None
 1.32A 1q23D-1s3iA:
undetectable
1q23E-1s3iA:
undetectable		 1q23D-1s3iA:
19.75
1q23E-1s3iA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		 1s3i 10-FORMYLTETRAHYDROF
OLATE DEHYDROGENASE
(Rattus
norvegicus) 		3 / 3 GLU A 201
HIS A 125
THR A 199
 None
 0.89A 3hkuA-1s3iA:
undetectable		 3hkuA-1s3iA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_C_DX2C270_1
(PTERIDINE REDUCTASE
1)		 1s3i 10-FORMYLTETRAHYDROF
OLATE DEHYDROGENASE
(Rattus
norvegicus) 		4 / 8 SER A   9
PHE A  11
VAL A  82
LEU A  19
 None
 1.14A 3jq7C-1s3iA:
7.7		 3jq7C-1s3iA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_B_ROCB203_1
(PROTEASE)		 1s3i 10-FORMYLTETRAHYDROF
OLATE DEHYDROGENASE
(Rattus
norvegicus) 		4 / 7 LEU A 277
LEU A 261
PRO A 264
ILE A 263
 None
 0.91A 3s56B-1s3iA:
undetectable		 3s56B-1s3iA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 1s3i 10-FORMYLTETRAHYDROF
OLATE DEHYDROGENASE
(Rattus
norvegicus) 		5 / 12 LEU A 287
PHE A 245
THR A 235
LEU A 261
ILE A 292
 None
 1.26A 3sp9A-1s3iA:
undetectable		 3sp9A-1s3iA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_A_TYLA1188_1
(BROMODOMAIN
CONTAINING 2)		 1s3i 10-FORMYLTETRAHYDROF
OLATE DEHYDROGENASE
(Rattus
norvegicus) 		4 / 5 VAL A 289
LEU A 279
LEU A 287
ILE A 211
 None
 0.93A 4a9jA-1s3iA:
undetectable		 4a9jA-1s3iA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 1s3i 10-FORMYLTETRAHYDROF
OLATE DEHYDROGENASE
(Rattus
norvegicus) 		4 / 6 ALA A 184
ALA A 188
PRO A 189
THR A 187
 None
None
BME  A 312 (-4.8A)
None
 1.04A 4dtzB-1s3iA:
undetectable		 4dtzB-1s3iA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)		 1s3i 10-FORMYLTETRAHYDROF
OLATE DEHYDROGENASE
(Rattus
norvegicus) 		4 / 6 LEU A 242
MET A 300
LEU A 277
ILE A 220
 None
 0.99A 4okxA-1s3iA:
undetectable		 4okxA-1s3iA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1s3i 10-FORMYLTETRAHYDROF
OLATE DEHYDROGENASE
(Rattus
norvegicus) 		5 / 12 ALA A 266
ALA A 233
ILE A 211
LEU A 287
GLY A 281
 None
 1.13A 4r38A-1s3iA:
undetectable		 4r38A-1s3iA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1s3i 10-FORMYLTETRAHYDROF
OLATE DEHYDROGENASE
(Rattus
norvegicus) 		5 / 12 ALA A 266
ALA A 233
ILE A 211
LEU A 287
GLY A 281
 None
 1.13A 4r38B-1s3iA:
undetectable		 4r38B-1s3iA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1s3i 10-FORMYLTETRAHYDROF
OLATE DEHYDROGENASE
(Rattus
norvegicus) 		5 / 12 ALA A 266
ALA A 233
ILE A 211
LEU A 287
GLY A 281
 None
 1.10A 4r38C-1s3iA:
undetectable		 4r38C-1s3iA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1s3i 10-FORMYLTETRAHYDROF
OLATE DEHYDROGENASE
(Rattus
norvegicus) 		5 / 12 ALA A 266
ALA A 233
ILE A 211
LEU A 287
GLY A 281
 None
 1.10A 4r38D-1s3iA:
undetectable		 4r38D-1s3iA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTR_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 1s3i 10-FORMYLTETRAHYDROF
OLATE DEHYDROGENASE
(Rattus
norvegicus) 		5 / 11 GLY A  43
PHE A  30
ILE A  90
TYR A  73
TYR A  16
 None
 1.46A 4rtrA-1s3iA:
2.5		 4rtrA-1s3iA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_C_ACTC1740_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT)		 1s3i 10-FORMYLTETRAHYDROF
OLATE DEHYDROGENASE
(Rattus
norvegicus) 		4 / 4 VAL A  27
GLU A  25
GLY A  77
LEU A  76
 None
 1.29A 5g5gC-1s3iA:
undetectable		 5g5gC-1s3iA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA405_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 1s3i 10-FORMYLTETRAHYDROF
OLATE DEHYDROGENASE
(Rattus
norvegicus) 		3 / 3 GLN A   8
THR A  31
ASP A  40
 None
 0.93A 5k9dA-1s3iA:
undetectable		 5k9dA-1s3iA:
23.36