SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1s3k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1D4F_B_ADNB602_2 (S-ADENOSYLHOMOCYSTEI NE HYDROLASE)	1s3k	HU3S193 FAB FRAGMENT, HEAVY CHAIN (Homo sapiens; Mus musculus)	4 / 5	THR H 78 THR H 24 GLU H 6 THR H 113	None	1.43A	1d4fB-1s3kH: undetectable	1d4fB-1s3kH: 18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4R3A_A_RBFA402_2 (BLUE-LIGHT-ACTIVATED HISTIDINE KINASE 2)	1s3k	HU3S193 FAB FRAGMENT, HEAVY CHAIN (Homo sapiens; Mus musculus)	5 / 8	THR H 197 ASN H 161 VAL H 188 LEU H 144 GLY H 196	None	1.38A	4r3aA-1s3kH: undetectable	4r3aA-1s3kH: 22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VEU_H_RITH602_2 (CYTOCHROME P450 3A5)	1s3k	HU3S193 FAB FRAGMENT, HEAVY CHAIN (Homo sapiens; Mus musculus)	4 / 5	PHE H 95 PHE H 106 LEU H 45 LEU H 81	None	0.99A	5veuH-1s3kH: undetectable	5veuH-1s3kH: 17.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6CJK_B_ACTB302_0 (IMMUNOGLOBULIN FAB HEAVY CHAIN)	1s3k	HU3S193 FAB FRAGMENT, HEAVY CHAIN (Homo sapiens; Mus musculus)	3 / 3	TYR H 60 GLY H 66 THR H 69	None	0.19A	6cjkB-1s3kH: 25.2	6cjkB-1s3kH: 61.43

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1D4F_B_ADNB602_2","S-ADENOSYLHOMOCYSTEINE HYDROLASE","1s3k","HU3S193 FAB FRAGMENT, HEAVY CHAIN","Homo sapiens;Mus musculus",4,"THR H  78;THR H  24;GLU H   6;THR H 113","None","1.43A","1d4fB-1s3kH:undetectable","1d4fB-1s3kH:18.27"],["4R3A_A_RBFA402_2","BLUE-LIGHT-ACTIVATED HISTIDINE KINASE 2","1s3k","HU3S193 FAB FRAGMENT, HEAVY CHAIN","Homo sapiens;Mus musculus",5,"THR H 197;ASN H 161;VAL H 188;LEU H 144;GLY H 196","None","1.38A","4r3aA-1s3kH:undetectable","4r3aA-1s3kH:22.25"],["5VEU_H_RITH602_2","CYTOCHROME P450 3A5","1s3k","HU3S193 FAB FRAGMENT, HEAVY CHAIN","Homo sapiens;Mus musculus",4,"PHE H  95;PHE H 106;LEU H  45;LEU H  81","None","0.99A","5veuH-1s3kH:undetectable","5veuH-1s3kH:17.90"],["6CJK_B_ACTB302_0","IMMUNOGLOBULIN FAB HEAVY CHAIN","1s3k","HU3S193 FAB FRAGMENT, HEAVY CHAIN","Homo sapiens;Mus musculus",3,"TYR H  60;GLY H  66;THR H  69","None","0.19A","6cjkB-1s3kH:25.2","6cjkB-1s3kH:61.43"]]