SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1s3n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 1s3n HYPOTHETICAL PROTEIN
MJ0936
(Methanocaldococc
us
jannaschii) 		3 / 3 ILE A  32
ILE A   5
THR A  56
 None
 0.62A 1rg7A-1s3nA:
undetectable		 1rg7A-1s3nA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VL2_A_BEZA1162_0
(PEROXIREDOXIN-5)		 1s3n HYPOTHETICAL PROTEIN
MJ0936
(Methanocaldococc
us
jannaschii) 		5 / 10 PRO A 137
GLY A 138
LEU A 104
THR A 121
GLY A  98
 None
 1.29A 2vl2A-1s3nA:
2.2
2vl2C-1s3nA:
1.9		 2vl2A-1s3nA:
21.74
2vl2C-1s3nA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_E_GCSE710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 1s3n HYPOTHETICAL PROTEIN
MJ0936
(Methanocaldococc
us
jannaschii) 		4 / 8 HIS A  10
ASP A  36
HIS A 122
ASP A   8
 MN  A 504 (-3.5A)
MN  A 503 ( 3.1A)
MN  A 504 (-4.0A)
MN  A 504 (-3.3A)
 1.11A 2xadA-1s3nA:
undetectable		 2xadA-1s3nA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_F_GCSF710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 1s3n HYPOTHETICAL PROTEIN
MJ0936
(Methanocaldococc
us
jannaschii) 		4 / 8 HIS A  10
ASP A  36
HIS A 122
ASP A   8
 MN  A 504 (-3.5A)
MN  A 503 ( 3.1A)
MN  A 504 (-4.0A)
MN  A 504 (-3.3A)
 1.10A 2xadB-1s3nA:
undetectable		 2xadB-1s3nA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_G_GCSG710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 1s3n HYPOTHETICAL PROTEIN
MJ0936
(Methanocaldococc
us
jannaschii) 		4 / 8 HIS A  10
ASP A  36
HIS A 122
ASP A   8
 MN  A 504 (-3.5A)
MN  A 503 ( 3.1A)
MN  A 504 (-4.0A)
MN  A 504 (-3.3A)
 1.09A 2xadC-1s3nA:
undetectable		 2xadC-1s3nA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_H_GCSH710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 1s3n HYPOTHETICAL PROTEIN
MJ0936
(Methanocaldococc
us
jannaschii) 		4 / 8 HIS A  10
ASP A  36
HIS A 122
ASP A   8
 MN  A 504 (-3.5A)
MN  A 503 ( 3.1A)
MN  A 504 (-4.0A)
MN  A 504 (-3.3A)
 1.09A 2xadD-1s3nA:
undetectable		 2xadD-1s3nA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA357_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 1s3n HYPOTHETICAL PROTEIN
MJ0936
(Methanocaldococc
us
jannaschii) 		3 / 3 HIS A  99
HIS A  97
HIS A 120
 None
MN  A 503 (-3.6A)
MN  A 503 (-3.6A)
 0.60A 3mihA-1s3nA:
0.0		 3mihA-1s3nA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA357_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 1s3n HYPOTHETICAL PROTEIN
MJ0936
(Methanocaldococc
us
jannaschii) 		3 / 3 HIS A 120
HIS A  99
HIS A  97
 MN  A 503 (-3.6A)
None
MN  A 503 (-3.6A)
 0.67A 3mihA-1s3nA:
0.0		 3mihA-1s3nA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_1
(GUANINE DEAMINASE)		 1s3n HYPOTHETICAL PROTEIN
MJ0936
(Methanocaldococc
us
jannaschii) 		5 / 12 HIS A 120
ALA A 107
HIS A  97
SER A   7
ASP A   8
 MN  A 503 (-3.6A)
None
MN  A 503 (-3.6A)
None
MN  A 504 (-3.3A)
 1.37A 4aqlA-1s3nA:
3.5		 4aqlA-1s3nA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB8_A_DXCA75_0
(PPCA)		 1s3n HYPOTHETICAL PROTEIN
MJ0936
(Methanocaldococc
us
jannaschii) 		4 / 8 ILE A  16
LEU A  13
ILE A  43
PHE A  41
 None
 0.85A 4hb8A-1s3nA:
undetectable		 4hb8A-1s3nA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_A_SAMA900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 1s3n HYPOTHETICAL PROTEIN
MJ0936
(Methanocaldococc
us
jannaschii) 		6 / 12 PHE A  46
GLY A   4
GLY A 151
ALA A  51
HIS A  33
ILE A  53
 None
 1.21A 4krhA-1s3nA:
undetectable		 4krhA-1s3nA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 1s3n HYPOTHETICAL PROTEIN
MJ0936
(Methanocaldococc
us
jannaschii) 		6 / 12 PHE A  46
GLY A   4
GLY A 151
ALA A  51
HIS A  33
ILE A  53
 None
 1.21A 4krhB-1s3nA:
2.9		 4krhB-1s3nA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 1s3n HYPOTHETICAL PROTEIN
MJ0936
(Methanocaldococc
us
jannaschii) 		6 / 12 PHE A  46
PHE A 126
GLY A   4
GLY A 151
ALA A  51
ILE A  53
 None
 1.14A 4krhB-1s3nA:
2.9		 4krhB-1s3nA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 1s3n HYPOTHETICAL PROTEIN
MJ0936
(Methanocaldococc
us
jannaschii) 		6 / 10 ILE A  53
LEU A  49
ILE A  16
ALA A  19
ILE A  20
ILE A 150
 None
 1.21A 5mvmD-1s3nA:
undetectable
5mvmE-1s3nA:
0.0		 5mvmD-1s3nA:
16.75
5mvmE-1s3nA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_C_ACTC301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 1s3n HYPOTHETICAL PROTEIN
MJ0936
(Methanocaldococc
us
jannaschii) 		5 / 6 ASP A  36
ASP A   8
HIS A  10
HIS A 122
HIS A  97
 MN  A 503 ( 3.1A)
MN  A 504 (-3.3A)
MN  A 504 (-3.5A)
MN  A 504 (-4.0A)
MN  A 503 (-3.6A)
 1.17A 5ncdB-1s3nA:
3.5
5ncdC-1s3nA:
undetectable		 5ncdB-1s3nA:
21.21
5ncdC-1s3nA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_A_ACTA302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 1s3n HYPOTHETICAL PROTEIN
MJ0936
(Methanocaldococc
us
jannaschii) 		5 / 6 ASP A  36
ASP A   8
HIS A  10
HIS A 122
HIS A  97
 MN  A 503 ( 3.1A)
MN  A 504 (-3.3A)
MN  A 504 (-3.5A)
MN  A 504 (-4.0A)
MN  A 503 (-3.6A)
 1.17A 5nelA-1s3nA:
undetectable
5nelD-1s3nA:
undetectable		 5nelA-1s3nA:
21.21
5nelD-1s3nA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA604_0
(THIOCYANATE
DEHYDROGENASE)		 1s3n HYPOTHETICAL PROTEIN
MJ0936
(Methanocaldococc
us
jannaschii) 		3 / 3 HIS A 120
HIS A  99
HIS A 100
 MN  A 503 (-3.6A)
None
None
 0.96A 5oexA-1s3nA:
undetectable		 5oexA-1s3nA:
17.47