SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1s4c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		 1s4c PROTEIN HI0227
(Haemophilus
influenzae) 		4 / 8 ILE A 108
PRO A 129
GLY A  84
PRO A  88
 None
 0.93A 3lslA-1s4cA:
undetectable
3lslD-1s4cA:
undetectable		 3lslA-1s4cA:
20.48
3lslD-1s4cA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		 1s4c PROTEIN HI0227
(Haemophilus
influenzae) 		4 / 8 PRO A  88
ILE A 108
PRO A 129
GLY A  84
 None
 0.94A 3lslA-1s4cA:
undetectable
3lslD-1s4cA:
undetectable		 3lslA-1s4cA:
20.48
3lslD-1s4cA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_A_CP6A602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1s4c PROTEIN HI0227
(Haemophilus
influenzae) 		5 / 12 ALA A  62
ILE A 108
PHE A 124
THR A 113
ILE A  81
 None
 1.08A 3qfxA-1s4cA:
undetectable		 3qfxA-1s4cA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_B_CP6B702_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1s4c PROTEIN HI0227
(Haemophilus
influenzae) 		5 / 12 ALA A  62
ILE A 108
PHE A 124
THR A 113
ILE A  81
 None
 1.09A 3qfxB-1s4cA:
undetectable		 3qfxB-1s4cA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVG_A_ACTA504_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 1s4c PROTEIN HI0227
(Haemophilus
influenzae) 		4 / 4 ALA A  62
LYS A  61
TYR A  93
GLU A  94
 None
 1.45A 4rvgA-1s4cA:
0.0		 4rvgA-1s4cA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 1s4c PROTEIN HI0227
(Haemophilus
influenzae) 		5 / 10 LEU A  74
LEU A  31
ASP A  30
ILE A 143
PRO A  52
 None
 1.31A 6dm0B-1s4cA:
undetectable
6dm0C-1s4cA:
undetectable		 6dm0B-1s4cA:
14.94
6dm0C-1s4cA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 1s4c PROTEIN HI0227
(Haemophilus
influenzae) 		5 / 10 LEU A  74
LEU A  31
ASP A  30
ILE A 143
PRO A  52
 None
 1.33A 6dm2B-1s4cA:
undetectable
6dm2C-1s4cA:
undetectable		 6dm2B-1s4cA:
14.94
6dm2C-1s4cA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 1s4c PROTEIN HI0227
(Haemophilus
influenzae) 		5 / 10 ILE A 143
PRO A  52
LEU A  74
LEU A  31
ASP A  30
 None
 1.34A 6dm2A-1s4cA:
undetectable
6dm2D-1s4cA:
undetectable		 6dm2A-1s4cA:
14.94
6dm2D-1s4cA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_D_AQ4D602_0
(CYTOCHROME P450 1A1)		 1s4c PROTEIN HI0227
(Haemophilus
influenzae) 		5 / 12 ILE A  81
PHE A 124
GLY A  84
ALA A  85
ILE A   3
 None
 1.05A 6dwnD-1s4cA:
undetectable		 6dwnD-1s4cA:
20.65