SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1s4d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_0
(FTSJ)		 1s4d UROPORPHYRIN-III
C-METHYLTRANSFERASE
(Pseudomonas
denitrificans
(nomen
rejiciendum)) 		5 / 12 ALA A 214
GLY A 101
GLY A 134
GLY A 135
LEU A  98
 None
SAH  A1501 (-3.5A)
GOL  A1001 ( 4.2A)
None
None
 1.01A 1ej0A-1s4dA:
undetectable		 1ej0A-1s4dA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_D_AG2D7015_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 1s4d UROPORPHYRIN-III
C-METHYLTRANSFERASE
(Pseudomonas
denitrificans
(nomen
rejiciendum)) 		4 / 7 LEU A 196
ARG A 201
LEU A 155
GLY A 246
 None
 0.82A 1n13D-1s4dA:
undetectable
1n13E-1s4dA:
undetectable		 1n13D-1s4dA:
16.20
1n13E-1s4dA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)		 1s4d UROPORPHYRIN-III
C-METHYLTRANSFERASE
(Pseudomonas
denitrificans
(nomen
rejiciendum)) 		4 / 8 VAL A 249
VAL A 243
PHE A 209
THR A 223
 None
 0.93A 3fhxB-1s4dA:
undetectable		 3fhxB-1s4dA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_A_CAMA423_0
(CYTOCHROME P450)		 1s4d UROPORPHYRIN-III
C-METHYLTRANSFERASE
(Pseudomonas
denitrificans
(nomen
rejiciendum)) 		5 / 10 TYR A 183
THR A 130
LEU A 136
VAL A 152
VAL A 179
 SAH  A1501 (-4.8A)
SAH  A1501 ( 3.6A)
None
None
None
 1.21A 3lxiA-1s4dA:
undetectable		 3lxiA-1s4dA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_2
(CYTOCHROME P450 3A4)		 1s4d UROPORPHYRIN-III
C-METHYLTRANSFERASE
(Pseudomonas
denitrificans
(nomen
rejiciendum)) 		5 / 9 ARG A 124
ILE A 125
LEU A 116
ARG A  94
GLY A  15
 None
 1.49A 3nxuB-1s4dA:
undetectable		 3nxuB-1s4dA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		 1s4d UROPORPHYRIN-III
C-METHYLTRANSFERASE
(Pseudomonas
denitrificans
(nomen
rejiciendum)) 		4 / 6 PRO A  24
GLY A  25
ASN A  51
ASN A 212
 SAH  A1501 (-4.9A)
None
None
None
 0.98A 3zqtA-1s4dA:
undetectable		 3zqtA-1s4dA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_B_CAMB1420_0
(CYTOCHROME P450)		 1s4d UROPORPHYRIN-III
C-METHYLTRANSFERASE
(Pseudomonas
denitrificans
(nomen
rejiciendum)) 		5 / 10 TYR A 183
THR A 130
LEU A 136
VAL A 152
VAL A 179
 SAH  A1501 (-4.8A)
SAH  A1501 ( 3.6A)
None
None
None
 1.25A 4c9nB-1s4dA:
undetectable		 4c9nB-1s4dA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_A_CAMA423_0
(CYTOCHROME P450)		 1s4d UROPORPHYRIN-III
C-METHYLTRANSFERASE
(Pseudomonas
denitrificans
(nomen
rejiciendum)) 		5 / 9 TYR A 183
THR A 130
LEU A 136
VAL A 152
VAL A 179
 SAH  A1501 (-4.8A)
SAH  A1501 ( 3.6A)
None
None
None
 1.24A 4c9pA-1s4dA:
undetectable		 4c9pA-1s4dA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_B_CAMB423_0
(CYTOCHROME P450)		 1s4d UROPORPHYRIN-III
C-METHYLTRANSFERASE
(Pseudomonas
denitrificans
(nomen
rejiciendum)) 		5 / 10 TYR A 183
THR A 130
LEU A 136
VAL A 152
VAL A 179
 SAH  A1501 (-4.8A)
SAH  A1501 ( 3.6A)
None
None
None
 1.24A 4c9pB-1s4dA:
undetectable		 4c9pB-1s4dA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_A_ADNA401_1
(APH(2'')-ID)		 1s4d UROPORPHYRIN-III
C-METHYLTRANSFERASE
(Pseudomonas
denitrificans
(nomen
rejiciendum)) 		5 / 11 ALA A 191
ILE A 173
LEU A 155
ILE A 168
ASP A 166
 None
 1.04A 4dt8A-1s4dA:
undetectable		 4dt8A-1s4dA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_B_ADNB401_1
(APH(2'')-ID)		 1s4d UROPORPHYRIN-III
C-METHYLTRANSFERASE
(Pseudomonas
denitrificans
(nomen
rejiciendum)) 		5 / 10 ALA A 191
ILE A 173
LEU A 155
ILE A 168
ASP A 166
 None
 1.02A 4dt8B-1s4dA:
undetectable		 4dt8B-1s4dA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 1s4d UROPORPHYRIN-III
C-METHYLTRANSFERASE
(Pseudomonas
denitrificans
(nomen
rejiciendum)) 		5 / 10 ALA A 191
ILE A 173
LEU A 155
ILE A 168
ASP A 166
 None
 0.97A 4dtaA-1s4dA:
undetectable		 4dtaA-1s4dA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1s4d UROPORPHYRIN-III
C-METHYLTRANSFERASE
(Pseudomonas
denitrificans
(nomen
rejiciendum)) 		5 / 12 ILE A 242
ALA A 213
LEU A 136
ALA A 137
VAL A 105
 SAH  A1501 (-4.5A)
SAH  A1501 (-3.2A)
None
None
SAH  A1501 (-4.1A)
 1.00A 4k6iA-1s4dA:
undetectable		 4k6iA-1s4dA:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1s4d UROPORPHYRIN-III
C-METHYLTRANSFERASE
(Pseudomonas
denitrificans
(nomen
rejiciendum)) 		4 / 8 GLN A  78
ASP A  80
ILE A  81
LYS A  99
 None
 0.90A 4kttD-1s4dA:
undetectable		 4kttD-1s4dA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 1s4d UROPORPHYRIN-III
C-METHYLTRANSFERASE
(Pseudomonas
denitrificans
(nomen
rejiciendum)) 		5 / 12 LEU A 136
VAL A 143
VAL A 243
PHE A 154
LEU A 196
 None
 1.30A 4nc3A-1s4dA:
undetectable		 4nc3A-1s4dA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 1s4d UROPORPHYRIN-III
C-METHYLTRANSFERASE
(Pseudomonas
denitrificans
(nomen
rejiciendum)) 		5 / 12 GLY A 135
GLY A 132
ILE A 129
ILE A 141
ALA A 137
 None
None
GOL  A1001 (-3.5A)
None
None
 0.95A 4qtuD-1s4dA:
2.2		 4qtuD-1s4dA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)		 1s4d UROPORPHYRIN-III
C-METHYLTRANSFERASE
(Pseudomonas
denitrificans
(nomen
rejiciendum)) 		5 / 9 ALA A 241
ILE A 141
GLY A 135
ALA A 131
VAL A 181
 None
None
None
SAH  A1501 (-3.4A)
None
 1.15A 4r1zA-1s4dA:
undetectable		 4r1zA-1s4dA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_C_SAMC4000_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 1s4d UROPORPHYRIN-III
C-METHYLTRANSFERASE
(Pseudomonas
denitrificans
(nomen
rejiciendum)) 		5 / 12 GLY A 109
GLY A 100
GLY A 107
ASP A  26
ASP A 102
 None
SAH  A1501 (-4.9A)
SAH  A1501 ( 4.1A)
None
None
 1.07A 5ehiC-1s4dA:
undetectable		 5ehiC-1s4dA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JI6_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME)		 1s4d UROPORPHYRIN-III
C-METHYLTRANSFERASE
(Pseudomonas
denitrificans
(nomen
rejiciendum)) 		4 / 5 GLY A 109
LEU A  19
SER A  82
GLN A  78
 None
 1.19A 6ji6A-1s4dA:
undetectable		 6ji6A-1s4dA:
21.65