SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1s4e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_B_NCAB700_0
(EXOTOXIN A)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		4 / 6 GLY A 113
TYR A  72
ALA A 135
GLU A 139
 None
ADP  A 400 (-3.6A)
None
MG  A 600 ( 4.9A)
 0.77A 1dmaB-1s4eA:
undetectable		 1dmaB-1s4eA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		4 / 7 LEU A 104
ILE A  94
THR A  35
TRP A  69
 None
ADP  A 400 (-4.0A)
ADP  A 400 ( 4.4A)
ADP  A 400 (-4.2A)
 1.30A 1kglA-1s4eA:
undetectable		 1kglA-1s4eA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		4 / 6 GLY A 215
ILE A 213
VAL A 222
SER A 210
 None
 1.04A 1rs7B-1s4eA:
undetectable		 1rs7B-1s4eA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		5 / 12 ILE A  15
GLY A 299
ALA A 313
ILE A 312
GLU A 250
 None
 1.12A 1vq1A-1s4eA:
undetectable		 1vq1A-1s4eA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		3 / 3 SER A   8
ASP A 151
CYH A 147
 None
GLA  A 500 (-3.0A)
GLA  A 500 (-4.5A)
 1.14A 2br4E-1s4eA:
undetectable		 2br4E-1s4eA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		4 / 8 ILE A 164
ASP A 151
LEU A 150
PHE A 153
 None
GLA  A 500 (-3.0A)
GLA  A 500 ( 4.4A)
None
 0.86A 2tsrB-1s4eA:
undetectable		 2tsrB-1s4eA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		5 / 7 LEU A 285
ALA A 305
GLY A 304
ARG A  11
PHE A 288
 None
GLA  A 500 (-3.7A)
GLA  A 500 (-4.0A)
GLA  A 500 (-4.3A)
None
 1.36A 2wq5A-1s4eA:
undetectable		 2wq5A-1s4eA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF0_A_PAUA314_0
(PANTOTHENATE KINASE)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		4 / 8 VAL A 280
ASP A 286
GLY A 308
HIS A 271
 None
 1.00A 3af0A-1s4eA:
undetectable		 3af0A-1s4eA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REQ_A_ADNA801_1
(METHYLMALONYL-COA
MUTASE)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		4 / 4 TYR A  21
TYR A 240
GLU A 244
GLY A  16
 GLA  A 500 ( 4.9A)
None
None
None
 1.39A 3reqA-1s4eA:
undetectable		 3reqA-1s4eA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D9H_A_ADNA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		5 / 11 SER A 109
GLY A 113
GLU A 111
SER A   8
VAL A 117
 None
 1.29A 4d9hA-1s4eA:
undetectable		 4d9hA-1s4eA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_A_NCAA1201_0
(TANKYRASE-2)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		4 / 7 GLY A 113
TYR A  72
ALA A 135
GLU A 139
 None
ADP  A 400 (-3.6A)
None
MG  A 600 ( 4.9A)
 0.72A 4hyfA-1s4eA:
undetectable		 4hyfA-1s4eA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		4 / 8 GLY A 113
TYR A  72
ALA A 135
GLU A 139
 None
ADP  A 400 (-3.6A)
None
MG  A 600 ( 4.9A)
 0.72A 4hyfB-1s4eA:
undetectable		 4hyfB-1s4eA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		4 / 8 GLY A 113
TYR A  72
ALA A 135
GLU A 139
 None
ADP  A 400 (-3.6A)
None
MG  A 600 ( 4.9A)
 0.73A 4hyfC-1s4eA:
undetectable		 4hyfC-1s4eA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_B_LURB201_1
(TRANSTHYRETIN)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		4 / 8 GLU A 139
ALA A 135
LEU A 133
VAL A 112
 MG  A 600 ( 4.9A)
None
None
None
 0.96A 4iizB-1s4eA:
undetectable		 4iizB-1s4eA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		4 / 7 ILE A 164
ASP A 151
LEU A 150
PHE A 153
 None
GLA  A 500 (-3.0A)
GLA  A 500 ( 4.4A)
None
 0.89A 4iqqA-1s4eA:
undetectable		 4iqqA-1s4eA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M48_A_21BA704_1
(TRANSPORTER)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		4 / 8 ASP A 151
SER A 105
GLY A 101
ALA A 196
 GLA  A 500 (-3.0A)
MG  A 600 (-4.0A)
ADP  A 400 (-3.2A)
None
 0.84A 4m48A-1s4eA:
undetectable		 4m48A-1s4eA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA7_A_P2ZA301_1
(MAJOR PRION PROTEIN)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		4 / 8 VAL A 280
LEU A 274
ILE A  15
VAL A  12
 None
 0.95A 4ma7A-1s4eA:
undetectable		 4ma7A-1s4eA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_A_29QA603_1
(TRANSPORTER)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		5 / 9 VAL A 155
ALA A 154
GLY A 351
SER A 347
GLY A 158
 None
 1.25A 4mmfA-1s4eA:
0.6		 4mmfA-1s4eA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		5 / 9 VAL A 155
ALA A 154
GLY A 351
SER A 347
GLY A 158
 None
 1.30A 4mmfB-1s4eA:
undetectable		 4mmfB-1s4eA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		4 / 8 THR A 223
LEU A 214
VAL A 242
SER A 239
 None
 1.22A 4qknA-1s4eA:
0.0		 4qknA-1s4eA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		5 / 10 VAL A 112
GLU A 111
LEU A 129
ALA A 132
THR A 168
 None
 1.27A 5m5cE-1s4eA:
undetectable		 5m5cE-1s4eA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1103_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		4 / 8 TYR A  72
ASP A 151
VAL A 143
GLY A 144
 ADP  A 400 (-3.6A)
GLA  A 500 (-3.0A)
None
None
 1.00A 5nzyA-1s4eA:
undetectable		 5nzyA-1s4eA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		5 / 12 GLU A 139
LEU A 302
SER A 107
GLY A 148
LEU A 150
 MG  A 600 ( 4.9A)
None
MG  A 600 ( 2.1A)
GLA  A 500 (-3.6A)
GLA  A 500 ( 4.4A)
 1.28A 5ogcB-1s4eA:
undetectable		 5ogcB-1s4eA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGJ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		3 / 3 VAL A 350
VAL A 156
GLN A 152
 None
 0.48A 5qgjA-1s4eA:
undetectable		 5qgjA-1s4eA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGL_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		3 / 3 VAL A 350
VAL A 156
GLN A 152
 None
 0.55A 5qglA-1s4eA:
undetectable		 5qglA-1s4eA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGM_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		3 / 3 VAL A 350
VAL A 156
GLN A 152
 None
 0.46A 5qgmA-1s4eA:
undetectable		 5qgmA-1s4eA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGN_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		3 / 3 VAL A 350
VAL A 156
GLN A 152
 None
 0.48A 5qgnA-1s4eA:
undetectable		 5qgnA-1s4eA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGU_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		3 / 3 VAL A 350
VAL A 156
GLN A 152
 None
 0.53A 5qguA-1s4eA:
undetectable		 5qguA-1s4eA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGV_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		3 / 3 VAL A 350
VAL A 156
GLN A 152
 None
 0.51A 5qgvA-1s4eA:
undetectable		 5qgvA-1s4eA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGW_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		3 / 3 VAL A 350
VAL A 156
GLN A 152
 None
 0.53A 5qgwA-1s4eA:
undetectable		 5qgwA-1s4eA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGX_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		3 / 3 VAL A 350
VAL A 156
GLN A 152
 None
 0.52A 5qgxA-1s4eA:
undetectable		 5qgxA-1s4eA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGY_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		3 / 3 VAL A 350
VAL A 156
GLN A 152
 None
 0.51A 5qgyA-1s4eA:
undetectable		 5qgyA-1s4eA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGZ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		3 / 3 VAL A 350
VAL A 156
GLN A 152
 None
 0.52A 5qgzA-1s4eA:
undetectable		 5qgzA-1s4eA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH0_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		3 / 3 VAL A 350
VAL A 156
GLN A 152
 None
 0.54A 5qh0A-1s4eA:
undetectable		 5qh0A-1s4eA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH1_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		3 / 3 VAL A 350
VAL A 156
GLN A 152
 None
 0.52A 5qh1A-1s4eA:
undetectable		 5qh1A-1s4eA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH2_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		3 / 3 VAL A 350
VAL A 156
GLN A 152
 None
 0.54A 5qh2A-1s4eA:
undetectable		 5qh2A-1s4eA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH3_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		3 / 3 VAL A 350
VAL A 156
GLN A 152
 None
 0.51A 5qh3A-1s4eA:
undetectable		 5qh3A-1s4eA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH4_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		3 / 3 VAL A 350
VAL A 156
GLN A 152
 None
 0.50A 5qh4A-1s4eA:
undetectable		 5qh4A-1s4eA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH5_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		3 / 3 VAL A 350
VAL A 156
GLN A 152
 None
 0.45A 5qh5A-1s4eA:
undetectable		 5qh5A-1s4eA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH6_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		3 / 3 VAL A 350
VAL A 156
GLN A 152
 None
 0.50A 5qh6A-1s4eA:
undetectable		 5qh6A-1s4eA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH7_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		3 / 3 VAL A 350
VAL A 156
GLN A 152
 None
 0.49A 5qh7A-1s4eA:
undetectable		 5qh7A-1s4eA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH9_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		3 / 3 VAL A 350
VAL A 156
GLN A 152
 None
 0.48A 5qh9A-1s4eA:
undetectable		 5qh9A-1s4eA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHA_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		3 / 3 VAL A 350
VAL A 156
GLN A 152
 None
 0.56A 5qhaA-1s4eA:
undetectable		 5qhaA-1s4eA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHC_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		3 / 3 VAL A 350
VAL A 156
GLN A 152
 None
 0.51A 5qhcA-1s4eA:
undetectable		 5qhcA-1s4eA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHE_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		3 / 3 VAL A 350
VAL A 156
GLN A 152
 None
 0.52A 5qheA-1s4eA:
undetectable		 5qheA-1s4eA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHF_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		3 / 3 VAL A 350
VAL A 156
GLN A 152
 None
 0.50A 5qhfA-1s4eA:
undetectable		 5qhfA-1s4eA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHG_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		3 / 3 VAL A 350
VAL A 156
GLN A 152
 None
 0.45A 5qhgA-1s4eA:
undetectable		 5qhgA-1s4eA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHH_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		3 / 3 VAL A 350
VAL A 156
GLN A 152
 None
 0.50A 5qhhA-1s4eA:
undetectable		 5qhhA-1s4eA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_A_NIZA808_1
(CATALASE-PEROXIDASE)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		4 / 8 GLU A 224
VAL A 242
GLY A 228
LEU A 230
 None
 0.65A 5sxqA-1s4eA:
undetectable		 5sxqA-1s4eA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_A_NIZA807_1
(CATALASE-PEROXIDASE)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		4 / 8 GLU A 224
VAL A 242
GLY A 228
LEU A 230
 None
 0.68A 5sxtA-1s4eA:
undetectable		 5sxtA-1s4eA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_B_NIZB808_1
(CATALASE-PEROXIDASE)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		4 / 8 GLU A 224
VAL A 242
GLY A 228
LEU A 230
 None
 0.64A 5sxtB-1s4eA:
undetectable		 5sxtB-1s4eA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB809_1
(CATALASE-PEROXIDASE)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		4 / 8 GLU A 224
VAL A 242
GLY A 228
LEU A 230
 None
 0.65A 5syjB-1s4eA:
undetectable		 5syjB-1s4eA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		5 / 12 ALA A 297
GLY A 264
ILE A  15
GLU A  17
LEU A 274
 None
None
None
GLA  A 500 (-3.6A)
None
 1.11A 5ul4A-1s4eA:
undetectable		 5ul4A-1s4eA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0C_D_TA1D502_1
(TUBULIN BETA CHAIN)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		6 / 12 VAL A 112
GLU A 111
LEU A 129
ALA A 132
LEU A 171
THR A 168
 None
 1.40A 6b0cD-1s4eA:
undetectable		 6b0cD-1s4eA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		4 / 6 ALA A 154
SER A 105
GLY A 103
ILE A 312
 None
MG  A 600 (-4.0A)
ADP  A 400 ( 4.1A)
None
 0.86A 6f8cA-1s4eA:
undetectable		 6f8cA-1s4eA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA826_0
(GEPHYRIN)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		3 / 3 HIS A 234
ARG A 205
ILE A 206
 None
 0.85A 6fgdA-1s4eA:
undetectable		 6fgdA-1s4eA:
22.22