SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1s4f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		 1s4f RNA-DEPENDENT RNA
POLYMERASE
(Pestivirus
A) 		3 / 3 ASP A 247
LEU A 240
LEU A 244
 None
 0.56A 1ikeA-1s4fA:
undetectable		 1ikeA-1s4fA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_A_BEZA349_0
(D-AMINO ACID OXIDASE)		 1s4f RNA-DEPENDENT RNA
POLYMERASE
(Pestivirus
A) 		4 / 5 TYR A 256
ILE A 380
ARG A 399
GLY A 401
 None
 1.05A 1kifA-1s4fA:
undetectable		 1kifA-1s4fA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_B_BEZB349_0
(D-AMINO ACID OXIDASE)		 1s4f RNA-DEPENDENT RNA
POLYMERASE
(Pestivirus
A) 		4 / 5 TYR A 256
ILE A 380
ARG A 399
GLY A 401
 None
 1.04A 1kifB-1s4fA:
undetectable		 1kifB-1s4fA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_C_BEZC349_0
(D-AMINO ACID OXIDASE)		 1s4f RNA-DEPENDENT RNA
POLYMERASE
(Pestivirus
A) 		4 / 5 TYR A 256
ILE A 380
ARG A 399
GLY A 401
 None
 1.05A 1kifC-1s4fA:
undetectable		 1kifC-1s4fA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_D_BEZD349_0
(D-AMINO ACID OXIDASE)		 1s4f RNA-DEPENDENT RNA
POLYMERASE
(Pestivirus
A) 		4 / 5 TYR A 256
ILE A 380
ARG A 399
GLY A 401
 None
 1.05A 1kifD-1s4fA:
undetectable		 1kifD-1s4fA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_E_BEZE349_0
(D-AMINO ACID OXIDASE)		 1s4f RNA-DEPENDENT RNA
POLYMERASE
(Pestivirus
A) 		4 / 5 TYR A 256
ILE A 380
ARG A 399
GLY A 401
 None
 1.05A 1kifE-1s4fA:
undetectable		 1kifE-1s4fA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_F_BEZF349_0
(D-AMINO ACID OXIDASE)		 1s4f RNA-DEPENDENT RNA
POLYMERASE
(Pestivirus
A) 		4 / 5 TYR A 256
ILE A 380
ARG A 399
GLY A 401
 None
 1.04A 1kifF-1s4fA:
undetectable		 1kifF-1s4fA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_G_BEZG349_0
(D-AMINO ACID OXIDASE)		 1s4f RNA-DEPENDENT RNA
POLYMERASE
(Pestivirus
A) 		4 / 5 TYR A 256
ILE A 380
ARG A 399
GLY A 401
 None
 1.05A 1kifG-1s4fA:
undetectable		 1kifG-1s4fA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_H_BEZH349_0
(D-AMINO ACID OXIDASE)		 1s4f RNA-DEPENDENT RNA
POLYMERASE
(Pestivirus
A) 		4 / 5 TYR A 256
ILE A 380
ARG A 399
GLY A 401
 None
 1.05A 1kifH-1s4fA:
undetectable		 1kifH-1s4fA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5R_A_RBFA859_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 1s4f RNA-DEPENDENT RNA
POLYMERASE
(Pestivirus
A) 		5 / 11 TYR A 581
ALA A 515
GLY A 516
TYR A 553
ARG A 529
 None
 1.38A 1l5rA-1s4fA:
undetectable		 1l5rA-1s4fA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		 1s4f RNA-DEPENDENT RNA
POLYMERASE
(Pestivirus
A) 		3 / 3 ASP A 247
LEU A 240
LEU A 244
 None
 0.56A 1np1B-1s4fA:
undetectable		 1np1B-1s4fA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_C_DEXC3999_1
(GLUCOCORTICOID
RECEPTOR)		 1s4f RNA-DEPENDENT RNA
POLYMERASE
(Pestivirus
A) 		5 / 12 GLY A 404
GLN A 407
LEU A 358
LEU A 417
THR A 346
 None
 1.26A 1p93C-1s4fA:
0.0		 1p93C-1s4fA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE9_A_BEZA352_0
(D-AMINO ACID OXIDASE)		 1s4f RNA-DEPENDENT RNA
POLYMERASE
(Pestivirus
A) 		4 / 5 TYR A 256
ILE A 380
ARG A 399
GLY A 401
 None
 1.06A 1ve9A-1s4fA:
undetectable		 1ve9A-1s4fA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_1
(POL POLYPROTEIN)		 1s4f RNA-DEPENDENT RNA
POLYMERASE
(Pestivirus
A) 		5 / 12 LEU A 669
GLY A 666
ALA A 590
ILE A 595
GLY A 596
 None
 0.66A 2avsA-1s4fA:
undetectable		 2avsA-1s4fA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B8J_B_ADNB331_1
(CLASS B ACID
PHOSPHATASE)		 1s4f RNA-DEPENDENT RNA
POLYMERASE
(Pestivirus
A) 		5 / 10 SER A 548
PHE A 547
GLY A 585
THR A 580
TYR A 582
 None
 1.33A 2b8jB-1s4fA:
0.0		 2b8jB-1s4fA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_G_BEZG2352_0
(D-AMINO-ACID OXIDASE)		 1s4f RNA-DEPENDENT RNA
POLYMERASE
(Pestivirus
A) 		4 / 5 TYR A 256
ILE A 380
ARG A 399
GLY A 401
 None
 1.03A 2du8G-1s4fA:
undetectable		 2du8G-1s4fA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_J_BEZJ3352_0
(D-AMINO-ACID OXIDASE)		 1s4f RNA-DEPENDENT RNA
POLYMERASE
(Pestivirus
A) 		4 / 5 TYR A 256
ILE A 380
ARG A 399
GLY A 401
 None
 1.02A 2du8J-1s4fA:
undetectable		 2du8J-1s4fA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD37_0
(GCN4 LEUCINE ZIPPER)		 1s4f RNA-DEPENDENT RNA
POLYMERASE
(Pestivirus
A) 		3 / 3 LYS A 172
ARG A 285
VAL A 286
 None
 1.07A 2r2vC-1s4fA:
0.0
2r2vD-1s4fA:
0.0		 2r2vC-1s4fA:
6.64
2r2vD-1s4fA:
6.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1s4f RNA-DEPENDENT RNA
POLYMERASE
(Pestivirus
A) 		4 / 5 ILE A 298
TYR A 256
MET A 384
THR A 385
 None
 1.42A 3abkN-1s4fA:
0.0
3abkW-1s4fA:
0.0		 3abkN-1s4fA:
20.67
3abkW-1s4fA:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 1s4f RNA-DEPENDENT RNA
POLYMERASE
(Pestivirus
A) 		4 / 5 TYR A 256
MET A 384
THR A 385
LEU A 358
 None
 1.39A 3ag1J-1s4fA:
0.0		 3ag1J-1s4fA:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 1s4f RNA-DEPENDENT RNA
POLYMERASE
(Pestivirus
A) 		5 / 11 ASN A 614
THR A 627
ILE A 148
THR A 519
LEU A 523
 None
 1.40A 3bf1C-1s4fA:
undetectable
3bf1D-1s4fA:
undetectable		 3bf1C-1s4fA:
18.80
3bf1D-1s4fA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		 1s4f RNA-DEPENDENT RNA
POLYMERASE
(Pestivirus
A) 		5 / 9 ASP A 350
ASN A 414
GLY A 447
ASP A 448
ASP A 449
 None
 0.95A 3sfuA-1s4fA:
27.7		 3sfuA-1s4fA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		 1s4f RNA-DEPENDENT RNA
POLYMERASE
(Pestivirus
A) 		5 / 9 ASP A 350
SER A 405
ASN A 414
ASP A 448
ASP A 449
 None
 1.18A 3sfuA-1s4fA:
27.7		 3sfuA-1s4fA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_B_RBVB601_1
(RNA POLYMERASE)		 1s4f RNA-DEPENDENT RNA
POLYMERASE
(Pestivirus
A) 		5 / 9 ASP A 350
ASN A 414
GLY A 447
ASP A 448
ASP A 449
 None
 0.91A 3sfuB-1s4fA:
27.5		 3sfuB-1s4fA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1s4f RNA-DEPENDENT RNA
POLYMERASE
(Pestivirus
A) 		3 / 3 GLN A 352
THR A 354
ASN A 178
 None
 0.78A 3v4tE-1s4fA:
0.3		 3v4tE-1s4fA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 1s4f RNA-DEPENDENT RNA
POLYMERASE
(Pestivirus
A) 		4 / 5 LEU A 458
ALA A 441
THR A 430
PHE A 437
 None
 1.25A 3vasB-1s4fA:
undetectable		 3vasB-1s4fA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB501_1
(HEMOLYTIC LECTIN
CEL-III)		 1s4f RNA-DEPENDENT RNA
POLYMERASE
(Pestivirus
A) 		4 / 5 SER A 415
GLY A 413
TRP A 349
ASP A 350
 None
 1.16A 3w9tB-1s4fA:
0.0		 3w9tB-1s4fA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1003_1
(HEMOLYTIC LECTIN
CEL-III)		 1s4f RNA-DEPENDENT RNA
POLYMERASE
(Pestivirus
A) 		4 / 5 SER A 415
GLY A 413
TRP A 349
ASP A 350
 None
 1.16A 3w9tC-1s4fA:
0.0		 3w9tC-1s4fA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD501_1
(HEMOLYTIC LECTIN
CEL-III)		 1s4f RNA-DEPENDENT RNA
POLYMERASE
(Pestivirus
A) 		4 / 5 SER A 415
GLY A 413
TRP A 349
ASP A 350
 None
 1.17A 3w9tD-1s4fA:
0.0		 3w9tD-1s4fA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1s4f RNA-DEPENDENT RNA
POLYMERASE
(Pestivirus
A) 		4 / 6 THR A 410
GLY A 413
ILE A 361
LYS A 475
 None
 1.07A 4acbC-1s4fA:
undetectable		 4acbC-1s4fA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_B_0HKB2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 1s4f RNA-DEPENDENT RNA
POLYMERASE
(Pestivirus
A) 		3 / 3 ASN A 556
LEU A 599
PHE A 549
 None
 0.72A 4dajB-1s4fA:
undetectable		 4dajB-1s4fA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)		 1s4f RNA-DEPENDENT RNA
POLYMERASE
(Pestivirus
A) 		4 / 5 SER A 343
GLY A 450
THR A 500
ASP A 449
 None
 1.10A 4eohA-1s4fA:
undetectable		 4eohA-1s4fA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_A_8PRA603_1
(TRANSPORTER)		 1s4f RNA-DEPENDENT RNA
POLYMERASE
(Pestivirus
A) 		5 / 12 TYR A 591
PHE A 547
SER A 554
ASP A 593
THR A 668
 None
 1.26A 4mm4A-1s4fA:
undetectable		 4mm4A-1s4fA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM7_A_29JA603_1
(TRANSPORTER)		 1s4f RNA-DEPENDENT RNA
POLYMERASE
(Pestivirus
A) 		5 / 10 TYR A 591
PHE A 547
SER A 554
ASP A 593
THR A 668
 None
 1.40A 4mm7A-1s4fA:
0.0		 4mm7A-1s4fA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6V_E_RBFE201_1
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E)		 1s4f RNA-DEPENDENT RNA
POLYMERASE
(Pestivirus
A) 		4 / 5 HIS A 444
GLU A 317
VAL A 329
LYS A 328
 None
 1.21A 4p6vB-1s4fA:
0.0
4p6vE-1s4fA:
undetectable		 4p6vB-1s4fA:
20.46
4p6vE-1s4fA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_1
(NUPC FAMILY PROTEIN)		 1s4f RNA-DEPENDENT RNA
POLYMERASE
(Pestivirus
A) 		5 / 12 GLN A 402
GLU A 177
TYR A 256
LEU A 358
GLU A 258
 None
 1.14A 4pd9A-1s4fA:
0.0		 4pd9A-1s4fA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1s4f RNA-DEPENDENT RNA
POLYMERASE
(Pestivirus
A) 		4 / 4 GLY A 459
VAL A 487
PHE A 491
ILE A 494
 None
 1.05A 4xv2B-1s4fA:
undetectable		 4xv2B-1s4fA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 1s4f RNA-DEPENDENT RNA
POLYMERASE
(Pestivirus
A) 		4 / 6 ILE A 361
THR A 381
TRP A 305
MET A 302
 None
 1.40A 5ljeA-1s4fA:
undetectable		 5ljeA-1s4fA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		 1s4f RNA-DEPENDENT RNA
POLYMERASE
(Pestivirus
A) 		4 / 6 PHE A 549
THR A 580
ARG A 529
ASP A 531
 None
 0.95A 5mraA-1s4fA:
undetectable
5mraB-1s4fA:
0.0		 5mraA-1s4fA:
15.56
5mraB-1s4fA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1T_A_SAMA605_0
(RADICAL SAM)		 1s4f RNA-DEPENDENT RNA
POLYMERASE
(Pestivirus
A) 		5 / 12 PHE A 462
LEU A 470
THR A 346
ASN A 418
THR A 454
 None
 1.45A 5v1tA-1s4fA:
undetectable		 5v1tA-1s4fA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_1
(REGULATORY PROTEIN
TETR)		 1s4f RNA-DEPENDENT RNA
POLYMERASE
(Pestivirus
A) 		4 / 7 GLY A 404
GLN A 308
TYR A 316
ASP A 409
 None
 1.29A 5vlmG-1s4fA:
undetectable		 5vlmG-1s4fA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1s4f RNA-DEPENDENT RNA
POLYMERASE
(Pestivirus
A) 		4 / 5 TYR A 256
MET A 384
THR A 385
LEU A 358
 None
 1.39A 5w97J-1s4fA:
0.0		 5w97J-1s4fA:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1s4f RNA-DEPENDENT RNA
POLYMERASE
(Pestivirus
A) 		4 / 5 TYR A 256
MET A 384
THR A 385
LEU A 358
 None
 1.42A 5x19J-1s4fA:
0.0		 5x19J-1s4fA:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1s4f RNA-DEPENDENT RNA
POLYMERASE
(Pestivirus
A) 		4 / 5 TYR A 256
MET A 384
THR A 385
LEU A 358
 None
 1.41A 5x1bJ-1s4fA:
0.0		 5x1bJ-1s4fA:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1s4f RNA-DEPENDENT RNA
POLYMERASE
(Pestivirus
A) 		4 / 5 TYR A 256
MET A 384
THR A 385
LEU A 358
 None
 1.41A 5x1bW-1s4fA:
undetectable		 5x1bW-1s4fA:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_2
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 1s4f RNA-DEPENDENT RNA
POLYMERASE
(Pestivirus
A) 		4 / 4 VAL A 419
LEU A 420
LEU A 188
ASP A 357
 None
 1.42A 5xv7A-1s4fA:
0.0		 5xv7A-1s4fA:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1s4f RNA-DEPENDENT RNA
POLYMERASE
(Pestivirus
A) 		4 / 7 TRP A 506
SER A 512
VAL A 502
ARG A 560
 None
 1.37A 6av6C-1s4fA:
undetectable
6av6D-1s4fA:
undetectable		 6av6C-1s4fA:
6.49
6av6D-1s4fA:
6.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1s4f RNA-DEPENDENT RNA
POLYMERASE
(Pestivirus
A) 		4 / 5 TYR A 256
MET A 384
THR A 385
LEU A 358
 None
 1.36A 6nknJ-1s4fA:
0.0		 6nknJ-1s4fA:
6.90