SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1s4o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 1s4o GLYCOLIPID
2-ALPHA-MANNOSYLTRAN
SFERASE
(Saccharomyces
cerevisiae) 		4 / 7 TYR A 319
ALA A 370
ALA A 368
LEU A 348
 None
 0.95A 2wx2A-1s4oA:
undetectable		 2wx2A-1s4oA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 1s4o GLYCOLIPID
2-ALPHA-MANNOSYLTRAN
SFERASE
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 319
ALA A 370
ALA A 368
LEU A 348
 None
 0.98A 2wx2B-1s4oA:
undetectable		 2wx2B-1s4oA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)		 1s4o GLYCOLIPID
2-ALPHA-MANNOSYLTRAN
SFERASE
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 319
ALA A 370
ALA A 368
LEU A 348
 None
 0.95A 3khmA-1s4oA:
undetectable		 3khmA-1s4oA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_A_TPFA490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 1s4o GLYCOLIPID
2-ALPHA-MANNOSYLTRAN
SFERASE
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 319
ALA A 370
ALA A 368
LEU A 348
 None
 0.96A 3l4dA-1s4oA:
undetectable		 3l4dA-1s4oA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8W_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1s4o GLYCOLIPID
2-ALPHA-MANNOSYLTRAN
SFERASE
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 172
VAL A 129
LEU A 128
LEU A 137
GLY A 183
 None
GDP  A 800 (-3.8A)
GDP  A 800 (-3.9A)
None
None
 1.04A 3n8wA-1s4oA:
undetectable		 3n8wA-1s4oA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA309_1
(BETA-LACTAMASE)		 1s4o GLYCOLIPID
2-ALPHA-MANNOSYLTRAN
SFERASE
(Saccharomyces
cerevisiae) 		4 / 5 ILE A 213
ARG A 130
GLU A 247
GLU A 133
 None
GDP  A 800 ( 3.3A)
MN  A 601 ( 3.1A)
GDP  A 800 (-2.9A)
 1.33A 3ny4A-1s4oA:
0.0		 3ny4A-1s4oA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_1
(MNMC2)		 1s4o GLYCOLIPID
2-ALPHA-MANNOSYLTRAN
SFERASE
(Saccharomyces
cerevisiae) 		4 / 6 HIS A 350
ASP A 346
ASN A 298
GLU A 300
 None
 1.27A 3vywA-1s4oA:
undetectable		 3vywA-1s4oA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EVR_A_BEZA401_0
(PUTATIVE ABC
TRANSPORTER SUBUNIT,
SUBSTRATE-BINDING
COMPONENT)		 1s4o GLYCOLIPID
2-ALPHA-MANNOSYLTRAN
SFERASE
(Saccharomyces
cerevisiae) 		5 / 11 TYR A 344
LEU A 348
VAL A 364
SER A 366
SER A 291
 None
 1.36A 4evrA-1s4oA:
0.0		 4evrA-1s4oA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1s4o GLYCOLIPID
2-ALPHA-MANNOSYLTRAN
SFERASE
(Saccharomyces
cerevisiae) 		4 / 7 CSS A 406
GLN A 410
PRO A 395
ASP A 397
 None
 0.88A 4z4gA-1s4oA:
0.0		 4z4gA-1s4oA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_1
(CDL2.2)		 1s4o GLYCOLIPID
2-ALPHA-MANNOSYLTRAN
SFERASE
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 231
MET A 264
ILE A 110
ALA A 368
LEU A 373
 None
 1.23A 5ienA-1s4oA:
undetectable		 5ienA-1s4oA:
16.36