SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1s4v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_B_IPBB600_0
(ODORANT-BINDING
PROTEIN)		 1s4v CYSTEINE
ENDOPEPTIDASE
(Ricinus
communis) 		4 / 4 ILE A 201
MET A 197
VAL A 128
GLY A 206
 None
 1.27A 1e06B-1s4vA:
0.4		 1e06B-1s4vA:
19.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 1s4v CYSTEINE
ENDOPEPTIDASE
(Ricinus
communis) 		6 / 10 GLN A  20
GLY A  24
SER A  25
PHE A  29
SER A  30
GLY A  67
 None
 1.17A 1stfE-1s4vA:
36.8
1stfI-1s4vA:
undetectable		 1stfE-1s4vA:
48.66
1stfI-1s4vA:
16.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 1s4v CYSTEINE
ENDOPEPTIDASE
(Ricinus
communis) 		7 / 10 GLN A  20
GLY A  24
SER A  25
TRP A  27
PHE A  29
SER A  30
HIS A 162
 None
 0.26A 1stfE-1s4vA:
36.8
1stfI-1s4vA:
undetectable		 1stfE-1s4vA:
48.66
1stfI-1s4vA:
16.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 1s4v CYSTEINE
ENDOPEPTIDASE
(Ricinus
communis) 		4 / 7 GLN A  20
GLY A  24
HIS A 162
TRP A 185
 None
 0.51A 3ai8A-1s4vA:
27.9		 3ai8A-1s4vA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)		 1s4v CYSTEINE
ENDOPEPTIDASE
(Ricinus
communis) 		3 / 3 TYR A  94
TYR A  89
GLY A  96
 None
 0.71A 3eteB-1s4vA:
undetectable
3eteD-1s4vA:
undetectable
3eteF-1s4vA:
undetectable		 3eteB-1s4vA:
19.16
3eteD-1s4vA:
19.16
3eteF-1s4vA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_2
(BIFUNCTIONAL AAC/APH)		 1s4v CYSTEINE
ENDOPEPTIDASE
(Ricinus
communis) 		3 / 3 LEU A  69
ASP A  71
TYR A  72
 None
 0.65A 4qc6B-1s4vA:
0.0		 4qc6B-1s4vA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 1s4v CYSTEINE
ENDOPEPTIDASE
(Ricinus
communis) 		4 / 8 GLU A  51
SER A  25
GLY A  68
TYR A  94
 None
 0.93A 5flcB-1s4vA:
0.0		 5flcB-1s4vA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 1s4v CYSTEINE
ENDOPEPTIDASE
(Ricinus
communis) 		4 / 8 GLU A  51
SER A  25
GLY A  68
TYR A  94
 None
 0.92A 5flcF-1s4vA:
0.0		 5flcF-1s4vA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_A_PQNA2001_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 1s4v CYSTEINE
ENDOPEPTIDASE
(Ricinus
communis) 		5 / 10 MET A 197
GLY A 200
ALA A 211
LEU A 124
LEU A  54
 None
 1.21A 6hqbA-1s4vA:
undetectable
6hqbJ-1s4vA:
undetectable		 6hqbA-1s4vA:
15.28
6hqbJ-1s4vA:
10.67