SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1s4y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_2
(NEURAMINIDASE)		 1s4y ACTIVIN RECEPTOR
TYPE IIB PRECURSOR
INHIBIN BETA A CHAIN
(Homo
sapiens;
Mus
musculus) 		3 / 3 ASP A  58
ARG B  87
ILE B 109
 None
 0.80A 1a4gB-1s4yA:
undetectable		 1a4gB-1s4yA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1s4y ACTIVIN RECEPTOR
TYPE IIB PRECURSOR
(Mus
musculus) 		4 / 8 TYR A  38
PHE A  91
ASN A  88
GLY A  54
 None
 1.01A 1ykiA-1s4yA:
undetectable
1ykiB-1s4yA:
undetectable		 1ykiA-1s4yA:
21.35
1ykiB-1s4yA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_B_NFZB2219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1s4y ACTIVIN RECEPTOR
TYPE IIB PRECURSOR
(Mus
musculus) 		4 / 8 TYR A  38
PHE A  91
ASN A  88
GLY A  54
 None
 1.03A 1ykiA-1s4yA:
undetectable
1ykiB-1s4yA:
undetectable		 1ykiA-1s4yA:
21.35
1ykiB-1s4yA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1s4y ACTIVIN RECEPTOR
TYPE IIB PRECURSOR
(Mus
musculus) 		4 / 8 TYR A  38
PHE A  91
ASN A  88
GLY A  54
 None
 1.00A 1ykiC-1s4yA:
undetectable
1ykiD-1s4yA:
undetectable		 1ykiC-1s4yA:
21.35
1ykiD-1s4yA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1s4y ACTIVIN RECEPTOR
TYPE IIB PRECURSOR
(Mus
musculus) 		4 / 8 TYR A  38
PHE A  91
ASN A  88
GLY A  54
 None
 1.02A 1ykiC-1s4yA:
undetectable
1ykiD-1s4yA:
undetectable		 1ykiC-1s4yA:
21.35
1ykiD-1s4yA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_2
(PHOSPHOLIPASE A2)		 1s4y ACTIVIN RECEPTOR
TYPE IIB PRECURSOR
INHIBIN BETA A CHAIN
(Homo
sapiens;
Mus
musculus) 		4 / 6 GLN A  31
GLY A  29
ARG B  87
LEU A  57
 None
 1.10A 3bjwE-1s4yA:
undetectable		 3bjwE-1s4yA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)		 1s4y ACTIVIN RECEPTOR
TYPE IIB PRECURSOR
INHIBIN BETA A CHAIN
(Mus
musculus;
Homo
sapiens) 		3 / 3 ASP A  59
TRP A  41
SER B  33
 None
 0.94A 4lrhA-1s4yA:
undetectable		 4lrhA-1s4yA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_A_ML1A302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1s4y INHIBIN BETA A CHAIN
(Homo
sapiens) 		4 / 8 PHE B  16
GLY B  34
MET B  89
ILE B  29
 None
 0.98A 4qogA-1s4yB:
undetectable
4qogB-1s4yB:
undetectable		 4qogA-1s4yB:
17.26
4qogB-1s4yB:
17.26