SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1s5k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AEG_A_4APA296_1
(CYTOCHROME C
PEROXIDASE)		 1s5k AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE
(Salmonella
enterica) 		4 / 8 HIS A 127
GLY A 131
MET A 112
LEU A  78
 None
 0.83A 1aegA-1s5kA:
undetectable		 1aegA-1s5kA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_1
(LIVER
CARBOXYLESTERASE I)		 1s5k AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE
(Salmonella
enterica) 		5 / 12 GLY A  80
VAL A  76
ILE A  97
LEU A  96
PHE A 132
 COA  A 600 ( 3.8A)
None
None
None
None
 0.97A 1mx1D-1s5kA:
undetectable		 1mx1D-1s5kA:
12.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 1s5k AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE
(Salmonella
enterica) 		4 / 8 ARG A  18
TRP A  22
GLU A  79
ASP A 115
 None
 0.39A 1s3zA-1s5kA:
26.2
1s3zB-1s5kA:
26.8		 1s3zA-1s5kA:
100.00
1s3zB-1s5kA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_1
(HEMK PROTEIN)		 1s5k AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE
(Salmonella
enterica) 		3 / 3 ASP A 115
PHE A 132
ASN A 120
 None
None
COA  A 600 ( 3.2A)
 0.88A 1sg9B-1s5kA:
undetectable		 1sg9B-1s5kA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_1
(STRUCTURAL PROTEIN
VP3)		 1s5k AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE
(Salmonella
enterica) 		3 / 3 GLU A  79
ASP A 115
ASP A  65
 None
 0.78A 3jb2A-1s5kA:
undetectable		 3jb2A-1s5kA:
9.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EVY_A_TOYA201_1
(AMINOGLYCOSIDE
N(6')-ACETYLTRANSFER
ASE TYPE 1)		 1s5k AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE
(Salmonella
enterica) 		5 / 9 ARG A  18
TRP A  22
GLU A  79
GLY A  80
ASP A 115
 None
None
None
COA  A 600 ( 3.8A)
None
 0.64A 4evyA-1s5kA:
23.3
4evyB-1s5kA:
22.8		 4evyA-1s5kA:
43.79
4evyB-1s5kA:
43.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EVY_B_TOYB201_1
(AMINOGLYCOSIDE
N(6')-ACETYLTRANSFER
ASE TYPE 1)		 1s5k AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE
(Salmonella
enterica) 		5 / 10 ARG A  18
TRP A  22
GLU A  79
GLY A  80
ASP A 115
 None
None
None
COA  A 600 ( 3.8A)
None
 0.76A 4evyA-1s5kA:
23.3
4evyB-1s5kA:
22.8		 4evyA-1s5kA:
43.79
4evyB-1s5kA:
43.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_C_SVRC301_1
(NUCLEOCAPSID PROTEIN)		 1s5k AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE
(Salmonella
enterica) 		4 / 8 GLY A 104
ASN A 106
LYS A 107
PHE A  46
 None
 0.93A 4j4vC-1s5kA:
undetectable		 4j4vC-1s5kA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 1s5k AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE
(Salmonella
enterica) 		4 / 7 ASN A   7
LYS A   8
LEU A  17
PHE A  82
 None
None
None
COA  A 600 (-4.5A)
 0.87A 4yv5A-1s5kA:
undetectable		 4yv5A-1s5kA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 1s5k AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE
(Salmonella
enterica) 		4 / 7 ASN A   7
LYS A   8
LEU A  17
PHE A  82
 None
None
None
COA  A 600 (-4.5A)
 0.96A 4yv5B-1s5kA:
undetectable		 4yv5B-1s5kA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1s5k AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE
(Salmonella
enterica) 		3 / 3 PHE A  46
ASP A  59
LEU A  84
 None
 0.66A 5uhbC-1s5kA:
undetectable		 5uhbC-1s5kA:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1s5k AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE
(Salmonella
enterica) 		3 / 3 PHE A  46
ASP A  59
LEU A  84
 None
 0.72A 5uhcC-1s5kA:
undetectable		 5uhcC-1s5kA:
8.73