SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1s5l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_2
(BETA-LACTAMASE
CTX-M-9)		 1s5l PHOTOSYSTEM II
MANGANESE-STABILIZIN
G POLYPEPTIDE
(Thermosynechococ
cus
elongatus) 		4 / 5 TYR O 151
PRO O 149
THR O  72
THR O  75
 None
 1.21A 1ymxB-1s5lO:
undetectable		 1ymxB-1s5lO:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_1
(PHOSPHOLIPASE A2)		 1s5l PHOTOSYSTEM II
MANGANESE-STABILIZIN
G POLYPEPTIDE
(Thermosynechococ
cus
elongatus) 		5 / 11 VAL O  66
LEU O  51
SER O 221
PRO O 117
THR O 107
 None
 1.32A 3bjwE-1s5lO:
undetectable		 3bjwE-1s5lO:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_A_1FLA502_1
(TRANSTHYRETIN)		 1s5l PHOTOSYSTEM II
MANGANESE-STABILIZIN
G POLYPEPTIDE
(Thermosynechococ
cus
elongatus) 		4 / 7 LYS O 203
ALA O 212
SER O 242
VAL O 238
 None
 0.72A 3d2tA-1s5lO:
undetectable		 3d2tA-1s5lO:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_B_1FLB500_1
(TRANSTHYRETIN)		 1s5l PHOTOSYSTEM II
MANGANESE-STABILIZIN
G POLYPEPTIDE
(Thermosynechococ
cus
elongatus) 		4 / 6 LYS O 203
ALA O 212
SER O 242
VAL O 238
 None
 0.77A 3d2tB-1s5lO:
undetectable		 3d2tB-1s5lO:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)		 1s5l PHOTOSYSTEM II
MANGANESE-STABILIZIN
G POLYPEPTIDE
(Thermosynechococ
cus
elongatus) 		3 / 3 LYS O 178
LEU O 182
ALA O 177
 None
 0.84A 4iizA-1s5lO:
0.0		 4iizA-1s5lO:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)		 1s5l PHOTOSYSTEM II
MANGANESE-STABILIZIN
G POLYPEPTIDE
(Thermosynechococ
cus
elongatus) 		6 / 12 LEU O  93
ALA O 127
ALA O 241
ILE O 243
ALA O  41
ILE O 211
 None
 1.36A 4o2bD-1s5lO:
undetectable		 4o2bD-1s5lO:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_0
(SERUM ALBUMIN)		 1s5l PHOTOSYSTEM II
MANGANESE-STABILIZIN
G POLYPEPTIDE
(Thermosynechococ
cus
elongatus) 		5 / 12 LEU O  43
PHE O 146
LEU O  51
GLY O 144
LEU O 199
 None
 1.18A 6a7pA-1s5lO:
undetectable		 6a7pA-1s5lO:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3A_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 1s5l PHOTOSYSTEM II
MANGANESE-STABILIZIN
G POLYPEPTIDE
(Thermosynechococ
cus
elongatus) 		5 / 12 GLY O  12
GLY O  14
TYR O   7
ALA O  16
ASP O   8
 None
 1.03A 6b3aA-1s5lO:
undetectable		 6b3aA-1s5lO:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_1
(CYTOCHROME P450 1A1)		 1s5l PHOTOSYSTEM II
MANGANESE-STABILIZIN
G POLYPEPTIDE
(Thermosynechococ
cus
elongatus) 		3 / 3 SER O 191
SER O 150
ALA O 227
 None
 0.59A 6dwnC-1s5lO:
undetectable		 6dwnC-1s5lO:
15.92