SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1s5p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_B_ESTB1600_1
(ESTROGEN RECEPTOR)		 1s5p NAD-DEPENDENT
DEACETYLASE
(Escherichia
coli) 		5 / 12 GLU A 136
LEU A 126
ILE A 200
GLY A 196
LEU A 195
 None
 1.25A 1g50B-1s5pA:
undetectable		 1g50B-1s5pA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_C_ESTC2600_1
(ESTROGEN RECEPTOR)		 1s5p NAD-DEPENDENT
DEACETYLASE
(Escherichia
coli) 		5 / 11 GLU A 136
LEU A 126
ILE A 200
GLY A 196
LEU A 195
 None
 1.26A 1g50C-1s5pA:
undetectable		 1g50C-1s5pA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)		 1s5p NAD-DEPENDENT
DEACETYLASE
(Escherichia
coli) 		5 / 11 THR A  47
GLY A  50
ILE A 211
LEU A 239
ALA A 258
 None
 0.95A 1x7pA-1s5pA:
4.6
1x7pB-1s5pA:
4.6		 1x7pA-1s5pA:
22.08
1x7pB-1s5pA:
22.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YC2_A_NCAA506_0
(NAD-DEPENDENT
DEACETYLASE 2)		 1s5p NAD-DEPENDENT
DEACETYLASE
(Escherichia
coli) 		5 / 6 ALA A  49
SER A  52
ASN A 130
ILE A 131
ASP A 132
 None
 0.35A 1yc2A-1s5pA:
21.9		 1yc2A-1s5pA:
39.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 1s5p NAD-DEPENDENT
DEACETYLASE
(Escherichia
coli) 		4 / 5 ALA A  49
ASN A 130
ILE A 131
ASP A 132
 None
 0.39A 1yc2D-1s5pA:
21.6		 1yc2D-1s5pA:
39.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 1s5p NAD-DEPENDENT
DEACETYLASE
(Escherichia
coli) 		4 / 7 ILE A  57
ASN A 130
ILE A 131
ASP A 132
 None
 0.36A 1yc2E-1s5pA:
21.8		 1yc2E-1s5pA:
39.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 1s5p NAD-DEPENDENT
DEACETYLASE
(Escherichia
coli) 		6 / 7 ALA A  49
SER A  52
ILE A  57
ASN A 130
ILE A 131
ASP A 132
 None
 0.34A 1yc5A-1s5pA:
20.2		 1yc5A-1s5pA:
33.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1s5p NAD-DEPENDENT
DEACETYLASE
(Escherichia
coli) 		4 / 6 LEU A 116
GLN A 117
LEU A 269
PHE A 265
 None
 1.12A 2einP-1s5pA:
undetectable
2einW-1s5pA:
undetectable		 2einP-1s5pA:
21.83
2einW-1s5pA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_D_ADND904_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 1s5p NAD-DEPENDENT
DEACETYLASE
(Escherichia
coli) 		5 / 12 SER A  52
HIS A 135
ILE A 211
THR A 128
ASN A 130
 None
 1.20A 2gl0D-1s5pA:
undetectable
2gl0E-1s5pA:
undetectable		 2gl0D-1s5pA:
20.59
2gl0E-1s5pA:
20.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 1s5p NAD-DEPENDENT
DEACETYLASE
(Escherichia
coli) 		5 / 5 ALA A  49
ILE A  57
ASN A 130
ILE A 131
ASP A 132
 None
 0.37A 2h4jA-1s5pA:
19.9		 2h4jA-1s5pA:
33.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J7X_A_ESTA1454_1
(ESTROGEN RECEPTOR
BETA)		 1s5p NAD-DEPENDENT
DEACETYLASE
(Escherichia
coli) 		5 / 12 GLU A 136
LEU A 126
ILE A 200
GLY A 196
LEU A 195
 None
 1.15A 2j7xA-1s5pA:
undetectable		 2j7xA-1s5pA:
23.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2NYR_B_SVRB401_1
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 1s5p NAD-DEPENDENT
DEACETYLASE
(Escherichia
coli) 		6 / 12 ALA A  49
THR A  59
ALA A  76
PHE A  91
TYR A  92
ILE A 131
 None
 0.90A 2nyrA-1s5pA:
18.8		 2nyrA-1s5pA:
36.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2NYR_B_SVRB401_1
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 1s5p NAD-DEPENDENT
DEACETYLASE
(Escherichia
coli) 		6 / 12 THR A  59
ALA A  76
PHE A  91
TYR A  92
ILE A 131
PHE A 190
 None
 0.93A 2nyrA-1s5pA:
18.8		 2nyrA-1s5pA:
36.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YJA_B_ESTB1550_1
(ESTROGEN RECEPTOR)		 1s5p NAD-DEPENDENT
DEACETYLASE
(Escherichia
coli) 		5 / 12 GLU A 136
LEU A 126
ILE A 200
GLY A 196
LEU A 195
 None
 1.15A 2yjaB-1s5pA:
undetectable		 2yjaB-1s5pA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_A_ROCA201_2
(PROTEASE)		 1s5p NAD-DEPENDENT
DEACETYLASE
(Escherichia
coli) 		5 / 9 ARG A 137
LEU A  99
GLY A  50
ILE A  51
ILE A 104
 None
 1.11A 3s56B-1s5pA:
undetectable		 3s56B-1s5pA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_B_SAMB401_0
(MNMC2)		 1s5p NAD-DEPENDENT
DEACETYLASE
(Escherichia
coli) 		5 / 12 HIS A 110
GLY A  48
GLY A  50
ALA A 222
LEU A  46
 None
 1.23A 3vywB-1s5pA:
undetectable		 3vywB-1s5pA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_0
(MNMC2)		 1s5p NAD-DEPENDENT
DEACETYLASE
(Escherichia
coli) 		5 / 12 HIS A 110
GLY A  48
GLY A  50
ALA A 222
LEU A  46
 None
 1.19A 3vywD-1s5pA:
undetectable		 3vywD-1s5pA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 1s5p NAD-DEPENDENT
DEACETYLASE
(Escherichia
coli) 		5 / 12 GLU A 136
LEU A 126
ILE A 200
GLY A 196
LEU A 195
 None
 1.14A 4j26A-1s5pA:
undetectable		 4j26A-1s5pA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1s5p NAD-DEPENDENT
DEACETYLASE
(Escherichia
coli) 		4 / 8 LEU A 113
LEU A 116
LEU A 120
ILE A 213
 None
 0.80A 4klaA-1s5pA:
undetectable		 4klaA-1s5pA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1s5p NAD-DEPENDENT
DEACETYLASE
(Escherichia
coli) 		4 / 8 PHE A  81
ASP A  82
SER A 156
ARG A 184
 None
 1.15A 4lv9A-1s5pA:
undetectable
4lv9B-1s5pA:
undetectable		 4lv9A-1s5pA:
20.65
4lv9B-1s5pA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 1s5p NAD-DEPENDENT
DEACETYLASE
(Escherichia
coli) 		4 / 5 GLY A  56
SER A  55
ALA A  53
GLU A  54
 None
 0.94A 4m93B-1s5pA:
undetectable
4m93C-1s5pA:
undetectable		 4m93B-1s5pA:
18.37
4m93C-1s5pA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1s5p NAD-DEPENDENT
DEACETYLASE
(Escherichia
coli) 		4 / 8 PRO A  41
LEU A 269
VAL A 237
VAL A  45
 None
 1.03A 4pwdA-1s5pA:
undetectable		 4pwdA-1s5pA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)		 1s5p NAD-DEPENDENT
DEACETYLASE
(Escherichia
coli) 		4 / 7 ILE A  57
ASN A 130
ILE A 131
ASP A 132
 None
 0.36A 4rmjA-1s5pA:
20.8		 4rmjA-1s5pA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 1s5p NAD-DEPENDENT
DEACETYLASE
(Escherichia
coli) 		5 / 12 ILE A 211
ALA A 212
ALA A 229
LEU A  44
PHE A 265
 None
 1.44A 4zo1X-1s5pA:
undetectable		 4zo1X-1s5pA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_B_ESTB601_1
(ESTROGEN RECEPTOR)		 1s5p NAD-DEPENDENT
DEACETYLASE
(Escherichia
coli) 		5 / 11 GLU A 136
LEU A 126
ILE A 200
GLY A 196
LEU A 195
 None
 1.16A 5dxbB-1s5pA:
undetectable		 5dxbB-1s5pA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 1s5p NAD-DEPENDENT
DEACETYLASE
(Escherichia
coli) 		5 / 12 GLU A 136
LEU A 126
ILE A 200
GLY A 196
LEU A 195
 None
 1.14A 5gs4A-1s5pA:
undetectable		 5gs4A-1s5pA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_1
(REGULATORY PROTEIN
TETR)		 1s5p NAD-DEPENDENT
DEACETYLASE
(Escherichia
coli) 		4 / 8 ARG A  97
GLN A 100
VAL A 168
ASP A 167
 None
 1.00A 5vlmA-1s5pA:
undetectable		 5vlmA-1s5pA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1s5p NAD-DEPENDENT
DEACETYLASE
(Escherichia
coli) 		4 / 5 LEU A 204
TYR A 201
ILE A 131
GLY A 224
 None
 1.02A 6hd6A-1s5pA:
undetectable		 6hd6A-1s5pA:
14.54