SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1s5t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_1
(HIV-1 PROTEASE)		 1s5t DIHYDRODIPICOLINATE
SYNTHASE
(Escherichia
coli) 		5 / 9 GLY A 201
GLY A 159
ILE A 160
VAL A  40
ILE A   6
 None
 1.13A 1hxwA-1s5tA:
undetectable		 1hxwA-1s5tA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1s5t DIHYDRODIPICOLINATE
SYNTHASE
(Escherichia
coli) 		4 / 7 LEU A 236
ASP A 188
LEU A 243
MET A 214
 None
 1.00A 1n13I-1s5tA:
0.0
1n13L-1s5tA:
undetectable		 1n13I-1s5tA:
14.22
1n13L-1s5tA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_B_H4BB1290_1
(PTERIDINE REDUCTASE
1)		 1s5t DIHYDRODIPICOLINATE
SYNTHASE
(Escherichia
coli) 		4 / 8 SER A  34
LEU A 259
TYR A  30
LEU A 239
 None
 0.96A 2bfpB-1s5tA:
undetectable		 2bfpB-1s5tA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_C_H4BC1290_1
(PTERIDINE REDUCTASE
1)		 1s5t DIHYDRODIPICOLINATE
SYNTHASE
(Escherichia
coli) 		4 / 8 SER A  34
LEU A 259
TYR A  30
LEU A 239
 None
 0.96A 2bfpC-1s5tA:
undetectable		 2bfpC-1s5tA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1s5t DIHYDRODIPICOLINATE
SYNTHASE
(Escherichia
coli) 		4 / 7 MET A 214
LEU A 236
ASP A 188
LEU A 243
 None
 1.05A 2qqcB-1s5tA:
undetectable
2qqcC-1s5tA:
undetectable		 2qqcB-1s5tA:
16.37
2qqcC-1s5tA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1s5t DIHYDRODIPICOLINATE
SYNTHASE
(Escherichia
coli) 		4 / 7 LEU A 236
ASP A 188
LEU A 243
MET A 214
 None
 1.06A 2qqcA-1s5tA:
undetectable
2qqcF-1s5tA:
undetectable		 2qqcA-1s5tA:
14.22
2qqcF-1s5tA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1s5t DIHYDRODIPICOLINATE
SYNTHASE
(Escherichia
coli) 		4 / 7 LEU A 236
ASP A 188
LEU A 243
MET A 214
 None
 1.05A 2qqcG-1s5tA:
undetectable
2qqcJ-1s5tA:
undetectable		 2qqcG-1s5tA:
14.22
2qqcJ-1s5tA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1s5t DIHYDRODIPICOLINATE
SYNTHASE
(Escherichia
coli) 		4 / 7 LEU A 236
ASP A 188
LEU A 243
MET A 214
 None
 1.05A 2qqcI-1s5tA:
undetectable
2qqcL-1s5tA:
undetectable		 2qqcI-1s5tA:
14.22
2qqcL-1s5tA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1s5t DIHYDRODIPICOLINATE
SYNTHASE
(Escherichia
coli) 		4 / 7 LEU A 236
ASP A 188
LEU A 243
MET A 214
 None
 1.04A 2qqdA-1s5tA:
undetectable
2qqdE-1s5tA:
undetectable		 2qqdA-1s5tA:
13.77
2qqdE-1s5tA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 1s5t DIHYDRODIPICOLINATE
SYNTHASE
(Escherichia
coli) 		5 / 12 ALA A 207
ALA A  38
SER A   5
LEU A 101
ILE A  74
 None
 1.17A 4lnwA-1s5tA:
undetectable		 4lnwA-1s5tA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1s5t DIHYDRODIPICOLINATE
SYNTHASE
(Escherichia
coli) 		3 / 3 MET A 237
ASP A 193
PHE A 194
 None
 1.05A 4xeyA-1s5tA:
0.0		 4xeyA-1s5tA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1s5t DIHYDRODIPICOLINATE
SYNTHASE
(Escherichia
coli) 		3 / 3 MET A 237
ASP A 193
PHE A 194
 None
 1.06A 4xeyB-1s5tA:
0.0		 4xeyB-1s5tA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP9_C_1WEC706_1
(TRANSPORTER)		 1s5t DIHYDRODIPICOLINATE
SYNTHASE
(Escherichia
coli) 		4 / 4 PHE A 181
ASP A 180
GLY A 159
SER A 178
 None
 1.30A 4xp9C-1s5tA:
undetectable		 4xp9C-1s5tA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_B_SAMB901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 1s5t DIHYDRODIPICOLINATE
SYNTHASE
(Escherichia
coli) 		5 / 12 PHE A   2
LEU A 183
GLY A 199
VAL A  40
ILE A   6
 None
 1.44A 6bxnB-1s5tA:
undetectable		 6bxnB-1s5tA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA806_0
(GEPHYRIN)		 1s5t DIHYDRODIPICOLINATE
SYNTHASE
(Escherichia
coli) 		4 / 4 MET A 195
GLY A 199
HIS A 200
GLY A 201
 None
 1.01A 6fgdA-1s5tA:
undetectable		 6fgdA-1s5tA:
21.40