SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1s68'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4008_1
(SERUM ALBUMIN)		 1s68 RNA LIGASE 2
(Escherichia
virus
T4) 		5 / 8 ALA A 194
LEU A 152
LEU A 153
LEU A 164
ALA A  32
 None
 1.40A 1e7cA-1s68A:
undetectable		 1e7cA-1s68A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_1
(WNT INHIBITORY
FACTOR 1)		 1s68 RNA LIGASE 2
(Escherichia
virus
T4) 		4 / 5 ILE A  36
PHE A 116
PRO A 151
VAL A 130
 AMP  A 301 (-4.9A)
None
None
None
 1.15A 2ygnA-1s68A:
undetectable		 2ygnA-1s68A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		 1s68 RNA LIGASE 2
(Escherichia
virus
T4) 		3 / 3 PRO A 165
GLU A 204
TYR A 206
 None
 0.81A 2zmbA-1s68A:
undetectable		 2zmbA-1s68A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWU_A_ADNA501_1
(DNA LIGASE)		 1s68 RNA LIGASE 2
(Escherichia
virus
T4) 		6 / 12 LYS A  35
ASN A  40
ARG A  55
PHE A 119
VAL A 207
LYS A 225
 AMP  A 301 (-2.8A)
AMP  A 301 (-3.9A)
AMP  A 301 (-2.7A)
AMP  A 301 (-3.7A)
AMP  A 301 (-4.1A)
AMP  A 301 (-2.5A)
 1.11A 3qwuA-1s68A:
11.9		 3qwuA-1s68A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWU_A_ADNA501_1
(DNA LIGASE)		 1s68 RNA LIGASE 2
(Escherichia
virus
T4) 		8 / 12 TYR A   5
LYS A  35
ASN A  40
GLU A  99
PHE A 119
VAL A 207
LYS A 209
LYS A 225
 None
AMP  A 301 (-2.8A)
AMP  A 301 (-3.9A)
AMP  A 301 (-3.1A)
AMP  A 301 (-3.7A)
AMP  A 301 (-4.1A)
AMP  A 301 ( 4.9A)
AMP  A 301 (-2.5A)
 0.63A 3qwuA-1s68A:
11.9		 3qwuA-1s68A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWU_B_ADNB501_1
(DNA LIGASE)		 1s68 RNA LIGASE 2
(Escherichia
virus
T4) 		5 / 11 LYS A  35
ASN A  40
ARG A  55
PHE A 119
VAL A 207
 AMP  A 301 (-2.8A)
AMP  A 301 (-3.9A)
AMP  A 301 (-2.7A)
AMP  A 301 (-3.7A)
AMP  A 301 (-4.1A)
 0.95A 3qwuB-1s68A:
6.6		 3qwuB-1s68A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWU_B_ADNB501_1
(DNA LIGASE)		 1s68 RNA LIGASE 2
(Escherichia
virus
T4) 		7 / 11 TYR A   5
LYS A  35
ASN A  40
GLU A  99
PHE A 119
VAL A 207
LYS A 209
 None
AMP  A 301 (-2.8A)
AMP  A 301 (-3.9A)
AMP  A 301 (-3.1A)
AMP  A 301 (-3.7A)
AMP  A 301 (-4.1A)
AMP  A 301 ( 4.9A)
 0.56A 3qwuB-1s68A:
6.6		 3qwuB-1s68A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U88_A_CHDA611_0
(MENIN)		 1s68 RNA LIGASE 2
(Escherichia
virus
T4) 		3 / 3 SER A 140
PHE A 145
LYS A 146
 None
 0.56A 3u88A-1s68A:
undetectable		 3u88A-1s68A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V20_A_ACTA1444_0
(CELLOBIOHYDROLASE)		 1s68 RNA LIGASE 2
(Escherichia
virus
T4) 		4 / 5 GLY A  38
THR A  39
GLY A 102
GLU A  99
 None
None
None
AMP  A 301 (-3.1A)
 1.17A 4v20A-1s68A:
undetectable		 4v20A-1s68A:
19.51