SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1s6i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_G_AG2G7003_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1s6i CALCIUM-DEPENDENT
PROTEIN KINASE SK5
(Glycine
max) 		4 / 6 LEU A  75
LEU A  36
GLY A  35
ILE A  27
 None
 0.85A 1mt1G-1s6iA:
undetectable
1mt1J-1s6iA:
undetectable		 1mt1G-1s6iA:
16.85
1mt1J-1s6iA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_K_AG2K7002_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 1s6i CALCIUM-DEPENDENT
PROTEIN KINASE SK5
(Glycine
max) 		4 / 7 ILE A  27
LEU A  75
LEU A  36
GLY A  35
 None
 0.88A 1mt1H-1s6iA:
undetectable
1mt1K-1s6iA:
undetectable		 1mt1H-1s6iA:
20.00
1mt1K-1s6iA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_F_AG2F7016_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1s6i CALCIUM-DEPENDENT
PROTEIN KINASE SK5
(Glycine
max) 		4 / 8 LEU A  75
LEU A  36
GLY A  35
ILE A  27
 None
 0.86A 1n13A-1s6iA:
undetectable
1n13F-1s6iA:
undetectable		 1n13A-1s6iA:
16.85
1n13F-1s6iA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_K_AG2K671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1s6i CALCIUM-DEPENDENT
PROTEIN KINASE SK5
(Glycine
max) 		4 / 8 ILE A  27
LEU A  75
LEU A  36
GLY A  35
 None
 0.89A 2qqcH-1s6iA:
undetectable
2qqcK-1s6iA:
undetectable		 2qqcH-1s6iA:
20.00
2qqcK-1s6iA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1s6i CALCIUM-DEPENDENT
PROTEIN KINASE SK5
(Glycine
max) 		4 / 7 ALA A 165
ASP A  92
GLY A 136
GLU A 137
 None
None
None
CA  A 192 (-2.5A)
 0.77A 5bs8A-1s6iA:
undetectable
5bs8C-1s6iA:
undetectable
5bs8D-1s6iA:
undetectable		 5bs8A-1s6iA:
15.19
5bs8C-1s6iA:
15.19
5bs8D-1s6iA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 1s6i CALCIUM-DEPENDENT
PROTEIN KINASE SK5
(Glycine
max) 		4 / 7 ALA A 165
ASP A  92
GLY A 136
GLU A 137
 None
None
None
CA  A 192 (-2.5A)
 0.78A 5bs8A-1s6iA:
undetectable
5bs8B-1s6iA:
undetectable
5bs8C-1s6iA:
undetectable		 5bs8A-1s6iA:
15.19
5bs8B-1s6iA:
21.15
5bs8C-1s6iA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1s6i CALCIUM-DEPENDENT
PROTEIN KINASE SK5
(Glycine
max) 		4 / 7 ALA A 165
ASP A  92
GLY A 136
GLU A 137
 None
None
None
CA  A 192 (-2.5A)
 0.79A 5btdA-1s6iA:
0.0
5btdC-1s6iA:
0.0
5btdD-1s6iA:
undetectable		 5btdA-1s6iA:
15.19
5btdC-1s6iA:
15.19
5btdD-1s6iA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1s6i CALCIUM-DEPENDENT
PROTEIN KINASE SK5
(Glycine
max) 		4 / 7 ALA A 165
ASP A  92
GLY A 136
GLU A 137
 None
None
None
CA  A 192 (-2.5A)
 0.77A 5btgA-1s6iA:
undetectable
5btgC-1s6iA:
undetectable
5btgD-1s6iA:
undetectable		 5btgA-1s6iA:
15.19
5btgC-1s6iA:
15.19
5btgD-1s6iA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_A_CXQA507_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 1s6i CALCIUM-DEPENDENT
PROTEIN KINASE SK5
(Glycine
max) 		4 / 5 ARG A 143
ALA A 139
TYR A 135
ILE A 151
 None
 1.17A 6f6sA-1s6iA:
undetectable
6f6sB-1s6iA:
undetectable		 6f6sA-1s6iA:
16.57
6f6sB-1s6iA:
17.50