SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1s6r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 1s6r BETA-LACTAMASE
(Enterobacter
cloacae) 		8 / 10 LEU A 119
GLN A 120
TYR A 150
ASN A 152
TYR A 221
LYS A 315
THR A 316
GLY A 317
 None
IAP  A   1 (-2.8A)
None
IAP  A   1 (-2.9A)
IAP  A   1 ( 3.9A)
IAP  A   1 ( 4.9A)
None
IAP  A   1 (-3.8A)
 0.60A 1kvlA-1s6rA:
59.9		 1kvlA-1s6rA:
69.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 1s6r BETA-LACTAMASE
(Enterobacter
cloacae) 		5 / 12 ALA A  77
LEU A 131
GLY A  74
LEU A 157
GLN A 219
 None
 1.16A 1qabF-1s6rA:
undetectable		 1qabF-1s6rA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_1
(POL POLYPROTEIN)		 1s6r BETA-LACTAMASE
(Enterobacter
cloacae) 		5 / 8 ILE A  78
GLY A  75
GLY A 251
ILE A 252
PRO A 307
 None
 1.21A 1sguA-1s6rA:
undetectable		 1sguA-1s6rA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_1
(MINERALOCORTICOID
RECEPTOR)		 1s6r BETA-LACTAMASE
(Enterobacter
cloacae) 		5 / 12 LEU A  62
ALA A 218
GLN A 219
MET A 174
THR A 225
 None
 1.33A 1ya3B-1s6rA:
undetectable		 1ya3B-1s6rA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 1s6r BETA-LACTAMASE
(Enterobacter
cloacae) 		5 / 11 THR A  42
ALA A 200
PRO A  53
ALA A 197
PHE A 322
 None
 1.34A 2admB-1s6rA:
undetectable		 2admB-1s6rA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		 1s6r BETA-LACTAMASE
(Enterobacter
cloacae) 		4 / 8 GLN A 219
ARG A 177
LEU A  73
VAL A 223
 None
 1.01A 2bdmA-1s6rA:
undetectable		 2bdmA-1s6rA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2002_1
(SERUM ALBUMIN)		 1s6r BETA-LACTAMASE
(Enterobacter
cloacae) 		5 / 11 ALA A  77
ALA A  79
ALA A 253
LEU A  73
VAL A  72
 None
 1.03A 2bxeB-1s6rA:
undetectable		 2bxeB-1s6rA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_2
(PROTEASE)		 1s6r BETA-LACTAMASE
(Enterobacter
cloacae) 		5 / 12 LEU A  62
ILE A 155
GLY A  71
VAL A  72
VAL A 223
 None
 0.88A 2o4lB-1s6rA:
undetectable		 2o4lB-1s6rA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_2
(AAC(6')-IB)		 1s6r BETA-LACTAMASE
(Enterobacter
cloacae) 		3 / 3 TRP A 101
GLN A 102
TRP A 142
 None
 1.20A 2vqyA-1s6rA:
undetectable		 2vqyA-1s6rA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 1s6r BETA-LACTAMASE
(Enterobacter
cloacae) 		3 / 3 TYR A 112
GLU A 272
ASN A 346
 None
 1.04A 2y7hC-1s6rA:
0.0		 2y7hC-1s6rA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		 1s6r BETA-LACTAMASE
(Enterobacter
cloacae) 		4 / 5 TYR A 325
ALA A  31
TYR A  41
MET A  28
 None
 1.23A 3d91A-1s6rA:
undetectable		 3d91A-1s6rA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA300_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 1s6r BETA-LACTAMASE
(Enterobacter
cloacae) 		5 / 12 LYS A  67
ASN A 152
LYS A 315
THR A 316
GLY A 317
 IAP  A   1 ( 4.0A)
IAP  A   1 (-2.9A)
IAP  A   1 ( 4.9A)
None
IAP  A   1 (-3.8A)
 0.67A 3huoA-1s6rA:
14.1		 3huoA-1s6rA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 1s6r BETA-LACTAMASE
(Enterobacter
cloacae) 		7 / 12 SER A  64
LYS A  67
ASN A 152
THR A 316
GLY A 317
THR A 319
ARG A 349
 IAP  A   1 (-1.4A)
IAP  A   1 ( 4.0A)
IAP  A   1 (-2.9A)
None
IAP  A   1 (-3.8A)
None
None
 0.94A 3mzeA-1s6rA:
14.1		 3mzeA-1s6rA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_1
(HIV-1 PROTEASE)		 1s6r BETA-LACTAMASE
(Enterobacter
cloacae) 		5 / 10 LEU A  62
ILE A 155
GLY A  71
VAL A  72
VAL A 223
 None
 0.89A 3oxwC-1s6rA:
undetectable		 3oxwC-1s6rA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_2
(HIV-1 PROTEASE)		 1s6r BETA-LACTAMASE
(Enterobacter
cloacae) 		5 / 11 LEU A  62
ILE A 155
GLY A  71
VAL A  72
VAL A 223
 None
 0.85A 3oxxD-1s6rA:
undetectable		 3oxxD-1s6rA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)		 1s6r BETA-LACTAMASE
(Enterobacter
cloacae) 		5 / 12 GLY A 268
ALA A 110
TRP A 271
LEU A 269
SER A 311
 None
 0.97A 3p2kD-1s6rA:
undetectable		 3p2kD-1s6rA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)		 1s6r BETA-LACTAMASE
(Enterobacter
cloacae) 		5 / 12 TYR A 170
ALA A 220
GLY A 222
LEU A 216
PHE A  69
 None
 1.26A 3pfgA-1s6rA:
undetectable		 3pfgA-1s6rA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_A_SAMA300_0
(PUTATIVE
METHYLTRANSFERASE)		 1s6r BETA-LACTAMASE
(Enterobacter
cloacae) 		5 / 12 ARG A 177
GLY A  75
MET A 106
GLU A  82
ALA A 162
 None
 1.34A 3t7sA-1s6rA:
undetectable		 3t7sA-1s6rA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 1s6r BETA-LACTAMASE
(Enterobacter
cloacae) 		5 / 12 ARG A 177
GLY A  75
MET A 106
GLU A  82
ALA A 162
 None
 1.33A 3t7sC-1s6rA:
undetectable		 3t7sC-1s6rA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_1
(POL POLYPROTEIN)		 1s6r BETA-LACTAMASE
(Enterobacter
cloacae) 		5 / 9 LEU A  85
ALA A 162
GLY A 156
ILE A 155
LEU A 107
 None
 1.02A 3u7sA-1s6rA:
undetectable		 3u7sA-1s6rA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ICL_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1s6r BETA-LACTAMASE
(Enterobacter
cloacae) 		5 / 12 LEU A 357
VAL A 234
TYR A 325
PHE A 328
TRP A 312
 None
 1.50A 4iclA-1s6rA:
0.0		 4iclA-1s6rA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_B_ACTB401_0
(UNCHARACTERIZED
PROTEIN)		 1s6r BETA-LACTAMASE
(Enterobacter
cloacae) 		4 / 5 VAL A 223
LEU A 179
VAL A 178
PHE A  69
 None
 1.05A 4lb0B-1s6rA:
undetectable		 4lb0B-1s6rA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_1
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 1s6r BETA-LACTAMASE
(Enterobacter
cloacae) 		4 / 5 SER A 264
GLU A 272
LYS A 315
ASN A 346
 None
None
IAP  A   1 ( 4.9A)
None
 1.43A 4pclA-1s6rA:
undetectable		 4pclA-1s6rA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 1s6r BETA-LACTAMASE
(Enterobacter
cloacae) 		3 / 3 LYS A 290
ARG A 349
VAL A 350
 None
 1.04A 4x3uA-1s6rA:
0.0
4x3uB-1s6rA:
0.0		 4x3uA-1s6rA:
10.00
4x3uB-1s6rA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 1s6r BETA-LACTAMASE
(Enterobacter
cloacae) 		3 / 3 LYS A   3
LEU A 357
ILE A  33
 None
 0.60A 5kc0A-1s6rA:
undetectable		 5kc0A-1s6rA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L94_A_TESA502_1
(CYTOCHROME P450)		 1s6r BETA-LACTAMASE
(Enterobacter
cloacae) 		5 / 8 VAL A  30
ALA A 353
VAL A  11
HIS A  39
VAL A  12
 None
 1.50A 5l94A-1s6rA:
undetectable		 5l94A-1s6rA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_2
(RIBOFLAVIN LYASE)		 1s6r BETA-LACTAMASE
(Enterobacter
cloacae) 		4 / 4 ASN A 226
GLN A 228
ASP A 229
THR A 175
 None
 1.18A 5w4zB-1s6rA:
0.0		 5w4zB-1s6rA:
11.70