SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1s70'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_B_SNLB2001_1
(MINERALOCORTICOID
RECEPTOR)		 1s70 130 KDA
MYOSIN-BINDING
SUBUNIT OF SMOOTH
MUSCLE MYOSIN
PHOPHATASE (M130)
(Gallus
gallus) 		5 / 12 LEU B  59
LEU B  45
ALA B  76
GLN B  79
MET B  88
 None
 1.29A 2oaxB-1s70B:
undetectable		 2oaxB-1s70B:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)		 1s70 130 KDA
MYOSIN-BINDING
SUBUNIT OF SMOOTH
MUSCLE MYOSIN
PHOPHATASE (M130)
(Gallus
gallus) 		5 / 12 ASN B 254
ASP B 257
ILE B 219
PRO B 235
LEU B 203
 None
 1.21A 3eeoA-1s70B:
undetectable		 3eeoA-1s70B:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1s70 130 KDA
MYOSIN-BINDING
SUBUNIT OF SMOOTH
MUSCLE MYOSIN
PHOPHATASE (M130)
(Gallus
gallus) 		4 / 4 LEU B 143
PRO B 142
LEU B 155
ARG B 161
 None
 1.25A 3hcoB-1s70B:
undetectable		 3hcoB-1s70B:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_A_BEZA264_0
(CARNITINYL-COA
DEHYDRATASE)		 1s70 130 KDA
MYOSIN-BINDING
SUBUNIT OF SMOOTH
MUSCLE MYOSIN
PHOPHATASE (M130)
(Gallus
gallus) 		5 / 6 ALA B 122
ILE B 126
LEU B 110
GLU B 148
ALA B 146
 None
 1.28A 3r9sA-1s70B:
undetectable		 3r9sA-1s70B:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB160_0
(HEME-BINDING PROTEIN
HUTZ)		 1s70 130 KDA
MYOSIN-BINDING
SUBUNIT OF SMOOTH
MUSCLE MYOSIN
PHOPHATASE (M130)
(Gallus
gallus) 		4 / 4 LEU B 277
GLY B 278
LEU B 280
GLU B 281
 None
 0.88A 3tgvB-1s70B:
undetectable		 3tgvB-1s70B:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_B_STRB301_1
(STEROID RECEPTOR 2)		 1s70 130 KDA
MYOSIN-BINDING
SUBUNIT OF SMOOTH
MUSCLE MYOSIN
PHOPHATASE (M130)
(Gallus
gallus) 		5 / 12 LEU B  59
LEU B  45
ALA B  76
GLN B  79
MET B  88
 None
 1.30A 4fn9B-1s70B:
undetectable		 4fn9B-1s70B:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1s70 130 KDA
MYOSIN-BINDING
SUBUNIT OF SMOOTH
MUSCLE MYOSIN
PHOPHATASE (M130)
(Gallus
gallus) 		4 / 6 LEU B 217
GLU B 174
VAL B 205
ALA B 202
 None
 0.89A 4nkxA-1s70B:
undetectable		 4nkxA-1s70B:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_C_AC2C301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1s70 130 KDA
MYOSIN-BINDING
SUBUNIT OF SMOOTH
MUSCLE MYOSIN
PHOPHATASE (M130)
(Gallus
gallus) 		5 / 11 GLY B 200
ALA B 206
GLU B 173
SER B 198
ASP B 229
 None
 1.08A 5i3cC-1s70B:
undetectable		 5i3cC-1s70B:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 1s70 130 KDA
MYOSIN-BINDING
SUBUNIT OF SMOOTH
MUSCLE MYOSIN
PHOPHATASE (M130)
(Gallus
gallus) 		3 / 3 ASP B 257
ASN B 288
GLN B 284
 None
 0.83A 5k7uA-1s70B:
undetectable		 5k7uA-1s70B:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 1s70 130 KDA
MYOSIN-BINDING
SUBUNIT OF SMOOTH
MUSCLE MYOSIN
PHOPHATASE (M130)
(Gallus
gallus) 		4 / 8 GLY B 133
HIS B 131
GLY B 106
ALA B 112
 None
 0.79A 6hu9H-1s70B:
undetectable
6hu9e-1s70B:
0.0		 6hu9H-1s70B:
16.43
6hu9e-1s70B:
18.24