SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1s72'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXH_B_PACB1001_0
(PENICILLIN ACYLASE)		 1s72 50S RIBOSOMAL
PROTEIN L10E
(Haloarcula
marismortui) 		4 / 7 PHE H 150
PHE H 134
SER H  68
ALA H 149
 None
 0.97A 1fxhA-1s72H:
undetectable
1fxhB-1s72H:
undetectable		 1fxhA-1s72H:
19.44
1fxhB-1s72H:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1s72 50S RIBOSOMAL
PROTEIN L15E
(Haloarcula
marismortui) 		4 / 6 ARG M  64
ASP M 135
ASN M 111
GLU M 130
 None
G  0 135 ( 3.6A)
U  0 134 ( 3.1A)
None
 1.21A 1rjdC-1s72M:
undetectable		 1rjdC-1s72M:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_F_DVAF8_0
(GRAMICIDIN A)		 1s72 50S RIBOSOMAL
PROTEIN L15E
(Haloarcula
marismortui) 		3 / 3 TRP M  31
VAL M  37
TRP M 128
 None
 1.32A 2xdcE-1s72M:
undetectable
2xdcF-1s72M:
undetectable		 2xdcE-1s72M:
5.33
2xdcF-1s72M:
5.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_2
(HIV-1 PROTEASE)		 1s72 50S RIBOSOMAL
PROTEIN L10E
(Haloarcula
marismortui) 		5 / 10 VAL H  94
ILE H  23
GLY H  25
PRO H  91
ALA H 124
 None
 1.00A 3t3cB-1s72H:
undetectable		 3t3cB-1s72H:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_B_DVAB8_0
(VAL-GRAMICIDIN A)		 1s72 50S RIBOSOMAL
PROTEIN L15E
(Haloarcula
marismortui) 		3 / 3 TRP M  31
VAL M  37
TRP M 128
 None
 1.28A 3zq8A-1s72M:
undetectable
3zq8B-1s72M:
undetectable		 3zq8A-1s72M:
5.33
3zq8B-1s72M:
5.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H2F_A_ADNA601_1
(5'-NUCLEOTIDASE)		 1s72 50S RIBOSOMAL
PROTEIN L15E
(Haloarcula
marismortui) 		5 / 9 ARG M 171
GLY M 167
GLY M 165
ARG M 168
GLY M 162
 A  0 189 ( 3.2A)
None
G  0 432 ( 3.0A)
C  0 433 ( 3.2A)
C  0 156 ( 4.1A)
 1.40A 4h2fA-1s72M:
undetectable		 4h2fA-1s72M:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ5_B_ACTB404_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1s72 50S RIBOSOMAL
PROTEIN L10E
(Haloarcula
marismortui) 		3 / 3 TYR H  43
ARG H  35
LYS H  38
 None
 1.46A 4wq5B-1s72H:
undetectable		 4wq5B-1s72H:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 1s72 50S RIBOSOMAL
PROTEIN L10E
(Haloarcula
marismortui) 		3 / 3 VAL H 146
GLN H  46
CYH H 138
 None
 0.77A 5icxA-1s72H:
0.0
5icxE-1s72H:
undetectable		 5icxA-1s72H:
19.46
5icxE-1s72H:
5.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 1s72 50S RIBOSOMAL
PROTEIN L15E
(Haloarcula
marismortui) 		4 / 6 PHE M 109
LEU M 133
ALA M 105
SER M 117
 U  0 134 (-4.5A)
None
None
None
 1.02A 6f88A-1s72M:
undetectable		 6f88A-1s72M:
18.23