SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1s78'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_D_CAMD502_0
(CAMPHOR
5-MONOOXYGENASE)		 1s78 PERTUZUMAB FAB HEAVY
CHAIN
(Mus
musculus) 		4 / 5 PHE D 122
GLY D 118
THR D 205
VAL D 207
 None
 1.00A 3wrkD-1s78D:
undetectable		 3wrkD-1s78D:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 1s78 PERTUZUMAB FAB HEAVY
CHAIN
(Mus
musculus) 		5 / 10 PHE D 122
GLY D 118
THR D 205
VAL D 198
VAL D 207
 None
 1.16A 4jx1B-1s78D:
undetectable		 4jx1B-1s78D:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M5M_A_DX4A401_0
(2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE)		 1s78 PERTUZUMAB FAB HEAVY
CHAIN
(Mus
musculus) 		4 / 8 GLY D  55
THR D  33
ASN D  52
ARG D  73
 None
 1.24A 4m5mA-1s78D:
undetectable		 4m5mA-1s78D:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		 1s78 PERTUZUMAB FAB HEAVY
CHAIN
(Mus
musculus) 		4 / 6 LEU D 124
THR D 183
ALA D 137
SER D 127
 None
 1.02A 4pwjA-1s78D:
undetectable		 4pwjA-1s78D:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 1s78 PERTUZUMAB FAB HEAVY
CHAIN
(Mus
musculus) 		5 / 7 PHE D 122
GLY D 118
THR D 205
VAL D 198
VAL D 207
 None
 1.24A 5ik1A-1s78D:
undetectable		 5ik1A-1s78D:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA606_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 1s78 PERTUZUMAB FAB HEAVY
CHAIN
(Mus
musculus) 		4 / 5 GLU D 148
PHE D 146
HIS D 200
THR D 110
 None
 1.07A 6b58A-1s78D:
undetectable		 6b58A-1s78D:
16.12