SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1s7g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MSK_A_SAMA1301_0
(COBALAMIN-DEPENDENT
METHIONINE SYNTHASE)		 1s7g NAD-DEPENDENT
DEACETYLASE 2
(Archaeoglobus
fulgidus) 		5 / 10 ARG A 108
ALA A 109
TYR A  83
PRO A  80
ALA A  81
 None
 1.28A 1mskA-1s7gA:
0.0		 1mskA-1s7gA:
21.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YC2_A_NCAA506_0
(NAD-DEPENDENT
DEACETYLASE 2)		 1s7g NAD-DEPENDENT
DEACETYLASE 2
(Archaeoglobus
fulgidus) 		5 / 6 ALA A  24
SER A  27
ASN A 101
ILE A 102
ASP A 103
 NAD  A 703 (-3.8A)
None
None
None
None
 0.14A 1yc2A-1s7gA:
42.4		 1yc2A-1s7gA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 1s7g NAD-DEPENDENT
DEACETYLASE 2
(Archaeoglobus
fulgidus) 		4 / 5 ALA A  24
ASN A 101
ILE A 102
ASP A 103
 NAD  A 703 (-3.8A)
None
None
None
 0.17A 1yc2D-1s7gA:
40.2		 1yc2D-1s7gA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 1s7g NAD-DEPENDENT
DEACETYLASE 2
(Archaeoglobus
fulgidus) 		4 / 7 ILE A  32
ASN A 101
ILE A 102
ASP A 103
 1PE  A 504 ( 4.7A)
None
None
None
 0.27A 1yc2E-1s7gA:
32.9		 1yc2E-1s7gA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 1s7g NAD-DEPENDENT
DEACETYLASE 2
(Archaeoglobus
fulgidus) 		6 / 7 ALA A  24
SER A  27
ILE A  32
ASN A 101
ILE A 102
ASP A 103
 NAD  A 703 (-3.8A)
None
1PE  A 504 ( 4.7A)
None
None
None
 0.29A 1yc5A-1s7gA:
27.6		 1yc5A-1s7gA:
42.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1s7g NAD-DEPENDENT
DEACETYLASE 2
(Archaeoglobus
fulgidus) 		4 / 5 LEU A  88
GLY A 191
ALA A  84
ILE A  85
 None
NAD  A 703 (-3.5A)
None
None
 0.84A 2aohB-1s7gA:
undetectable		 2aohB-1s7gA:
13.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 1s7g NAD-DEPENDENT
DEACETYLASE 2
(Archaeoglobus
fulgidus) 		5 / 5 ALA A  24
ILE A  32
ASN A 101
ILE A 102
ASP A 103
 NAD  A 703 (-3.8A)
1PE  A 504 ( 4.7A)
None
None
None
 0.34A 2h4jA-1s7gA:
27.1		 2h4jA-1s7gA:
42.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1s7g NAD-DEPENDENT
DEACETYLASE 2
(Archaeoglobus
fulgidus) 		5 / 8 LEU A  12
VAL A 238
LEU A 239
ILE A 231
VAL A 216
 None
 1.15A 3kp6A-1s7gA:
undetectable
3kp6B-1s7gA:
undetectable		 3kp6A-1s7gA:
19.07
3kp6B-1s7gA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_G_ACTG601_0
(CHOLINE OXIDASE)		 1s7g NAD-DEPENDENT
DEACETYLASE 2
(Archaeoglobus
fulgidus) 		4 / 6 ALA A  86
ILE A  85
HIS A 106
VAL A 114
 None
 1.09A 3nneG-1s7gA:
undetectable		 3nneG-1s7gA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5S_A_ACHA1289_0
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 1s7g NAD-DEPENDENT
DEACETYLASE 2
(Archaeoglobus
fulgidus) 		4 / 6 VAL A  50
ASN A  59
TYR A  45
GLU A  69
 None
 1.20A 3q5sA-1s7gA:
undetectable		 3q5sA-1s7gA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_F_CAMF502_0
(CAMPHOR
5-MONOOXYGENASE)		 1s7g NAD-DEPENDENT
DEACETYLASE 2
(Archaeoglobus
fulgidus) 		4 / 4 TYR A 204
THR A 221
VAL A 189
ILE A 226
 None
 1.34A 4jx1F-1s7gA:
0.0		 4jx1F-1s7gA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 1s7g NAD-DEPENDENT
DEACETYLASE 2
(Archaeoglobus
fulgidus) 		4 / 5 HIS A 118
PHE A 165
LEU A 169
PRO A 198
 NAD  A 703 ( 4.9A)
EDO  A 505 ( 4.0A)
None
None
 0.97A 4o8zA-1s7gA:
23.2		 4o8zA-1s7gA:
29.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1s7g NAD-DEPENDENT
DEACETYLASE 2
(Archaeoglobus
fulgidus) 		4 / 6 GLU A 176
THR A 173
THR A  22
HIS A 106
 None
SO4  A 401 (-4.6A)
None
None
 1.26A 4pfjB-1s7gA:
4.4		 4pfjB-1s7gA:
19.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)		 1s7g NAD-DEPENDENT
DEACETYLASE 2
(Archaeoglobus
fulgidus) 		4 / 7 ILE A  32
ASN A 101
ILE A 102
ASP A 103
 1PE  A 504 ( 4.7A)
None
None
None
 0.31A 4rmjA-1s7gA:
23.9		 4rmjA-1s7gA:
31.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1s7g NAD-DEPENDENT
DEACETYLASE 2
(Archaeoglobus
fulgidus) 		4 / 5 ALA A  62
ARG A  58
ALA A  51
GLU A  48
 None
None
EDO  A 505 ( 4.0A)
None
 1.46A 5a06C-1s7gA:
4.4
5a06D-1s7gA:
4.4		 5a06C-1s7gA:
20.69
5a06D-1s7gA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		 1s7g NAD-DEPENDENT
DEACETYLASE 2
(Archaeoglobus
fulgidus) 		4 / 8 ASN A  59
PRO A  60
PHE A  56
SER A  54
 None
None
None
SO4  A 412 ( 4.5A)
 1.33A 5amiB-1s7gA:
undetectable		 5amiB-1s7gA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1s7g NAD-DEPENDENT
DEACETYLASE 2
(Archaeoglobus
fulgidus) 		5 / 12 VAL A 189
PHE A  21
VAL A  20
ILE A  32
ALA A  28
 None
None
None
1PE  A 504 ( 4.7A)
NAD  A 703 ( 3.7A)
 0.91A 5n0sA-1s7gA:
undetectable		 5n0sA-1s7gA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1s7g NAD-DEPENDENT
DEACETYLASE 2
(Archaeoglobus
fulgidus) 		5 / 12 VAL A 189
PHE A  21
VAL A  20
ILE A  32
ALA A  28
 None
None
None
1PE  A 504 ( 4.7A)
NAD  A 703 ( 3.7A)
 0.92A 5n0sB-1s7gA:
0.6		 5n0sB-1s7gA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1s7g NAD-DEPENDENT
DEACETYLASE 2
(Archaeoglobus
fulgidus) 		5 / 12 VAL A 189
PHE A  21
VAL A  20
ILE A  32
ALA A  28
 None
None
None
1PE  A 504 ( 4.7A)
NAD  A 703 ( 3.7A)
 0.95A 5n0tA-1s7gA:
3.2		 5n0tA-1s7gA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1s7g NAD-DEPENDENT
DEACETYLASE 2
(Archaeoglobus
fulgidus) 		5 / 12 VAL A 189
PHE A  21
VAL A  20
ILE A  32
ALA A  28
 None
None
None
1PE  A 504 ( 4.7A)
NAD  A 703 ( 3.7A)
 0.95A 5n0wB-1s7gA:
3.5		 5n0wB-1s7gA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1s7g NAD-DEPENDENT
DEACETYLASE 2
(Archaeoglobus
fulgidus) 		5 / 12 VAL A 189
PHE A  21
VAL A  20
ILE A  32
ALA A  28
 None
None
None
1PE  A 504 ( 4.7A)
NAD  A 703 ( 3.7A)
 0.95A 5n4iA-1s7gA:
3.6		 5n4iA-1s7gA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BM5_A_SAMA1301_0
(METHIONINE SYNTHASE)		 1s7g NAD-DEPENDENT
DEACETYLASE 2
(Archaeoglobus
fulgidus) 		5 / 11 ARG A 108
ALA A 109
TYR A  83
PRO A  80
ALA A  81
 None
 1.25A 6bm5A-1s7gA:
undetectable		 6bm5A-1s7gA:
22.09