SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1s7j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B02_A_C2FA281_0
(PROTEIN (THYMIDYLATE
SYNTHASE))		 1s7j PHENAZINE
BIOSYNTHESIS PROTEIN
PHZF FAMILY
(Enterococcus
faecalis) 		5 / 11 ALA A  48
THR A  78
LEU A 235
ASP A 200
ALA A 206
 None
 1.09A 1b02A-1s7jA:
0.0		 1b02A-1s7jA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLB_A_NVPA999_1
(HIV-1 RT A-CHAIN)		 1s7j PHENAZINE
BIOSYNTHESIS PROTEIN
PHZF FAMILY
(Enterococcus
faecalis) 		4 / 8 VAL A 184
TYR A 226
GLY A 181
LEU A 235
 None
 0.91A 1jlbA-1s7jA:
undetectable		 1jlbA-1s7jA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1413_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 1s7j PHENAZINE
BIOSYNTHESIS PROTEIN
PHZF FAMILY
(Enterococcus
faecalis) 		4 / 6 ALA A 208
ALA A 206
THR A 190
PHE A 192
 None
 1.06A 2xfhA-1s7jA:
undetectable		 2xfhA-1s7jA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_C_TYLC1184_1
(BROMODOMAIN
CONTAINING 2)		 1s7j PHENAZINE
BIOSYNTHESIS PROTEIN
PHZF FAMILY
(Enterococcus
faecalis) 		4 / 5 VAL A 175
LEU A 166
LEU A 169
ILE A 137
 None
 0.86A 4a9jC-1s7jA:
undetectable		 4a9jC-1s7jA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_A_SAMA900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 1s7j PHENAZINE
BIOSYNTHESIS PROTEIN
PHZF FAMILY
(Enterococcus
faecalis) 		5 / 12 PHE A 186
GLY A 247
GLY A 248
HIS A 207
ILE A 211
 None
 1.02A 4krhA-1s7jA:
undetectable		 4krhA-1s7jA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 1s7j PHENAZINE
BIOSYNTHESIS PROTEIN
PHZF FAMILY
(Enterococcus
faecalis) 		5 / 12 PHE A 186
GLY A 247
GLY A 248
HIS A 207
ILE A 211
 None
 1.06A 4krhB-1s7jA:
undetectable		 4krhB-1s7jA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 1s7j PHENAZINE
BIOSYNTHESIS PROTEIN
PHZF FAMILY
(Enterococcus
faecalis) 		4 / 5 LEU A 169
VAL A 177
TYR A 129
ARG A 231
 None
 1.13A 4r7iA-1s7jA:
undetectable		 4r7iA-1s7jA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L7I_A_VISA1202_1
(SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG)		 1s7j PHENAZINE
BIOSYNTHESIS PROTEIN
PHZF FAMILY
(Enterococcus
faecalis) 		5 / 12 ASN A  19
ASP A 200
ARG A 144
ASN A 209
LEU A 210
 None
 1.36A 5l7iA-1s7jA:
0.0		 5l7iA-1s7jA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WHY_A_SAMA504_0
(RADICAL SAM DOMAIN
PROTEIN)		 1s7j PHENAZINE
BIOSYNTHESIS PROTEIN
PHZF FAMILY
(Enterococcus
faecalis) 		5 / 11 PHE A 147
GLU A 139
THR A 178
VAL A 239
VAL A 244
 None
 1.41A 5whyA-1s7jA:
undetectable		 5whyA-1s7jA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WHY_B_SAMB504_0
(RADICAL SAM DOMAIN
PROTEIN)		 1s7j PHENAZINE
BIOSYNTHESIS PROTEIN
PHZF FAMILY
(Enterococcus
faecalis) 		5 / 10 PHE A 147
GLU A 139
THR A 178
VAL A 239
VAL A 244
 None
 1.39A 5whyB-1s7jA:
0.0		 5whyB-1s7jA:
20.70