SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1s8e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_0
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 1s8e EXONUCLEASE PUTATIVE
(Pyrococcus
furiosus) 		5 / 12 LEU A 138
ALA A 168
SER A 218
PHE A 261
LEU A 158
 None
 1.06A 1kglA-1s8eA:
undetectable		 1kglA-1s8eA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 1s8e EXONUCLEASE PUTATIVE
(Pyrococcus
furiosus) 		5 / 12 LEU A  33
VAL A  94
LEU A  95
LEU A  98
LEU A  67
 None
 0.99A 1mx1C-1s8eA:
undetectable		 1mx1C-1s8eA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 1s8e EXONUCLEASE PUTATIVE
(Pyrococcus
furiosus) 		5 / 12 ILE A 190
HIS A 206
GLY A 175
ASP A  49
GLY A  48
 None
MN  A 401 (-3.5A)
None
MN  A 401 ( 2.7A)
None
 1.06A 1zz1C-1s8eA:
undetectable		 1zz1C-1s8eA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		 1s8e EXONUCLEASE PUTATIVE
(Pyrococcus
furiosus) 		3 / 3 LEU A  98
LEU A  33
PHE A  51
 None
 0.55A 2pgrA-1s8eA:
3.4		 2pgrA-1s8eA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_C_VD3C2001_1
(VITAMIN D
HYDROXYLASE)		 1s8e EXONUCLEASE PUTATIVE
(Pyrococcus
furiosus) 		5 / 11 ILE A 296
LEU A 320
LEU A 292
ILE A 289
LEU A 326
 None
 1.29A 3a50C-1s8eA:
undetectable		 3a50C-1s8eA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_E_VD3E2001_1
(VITAMIN D
HYDROXYLASE)		 1s8e EXONUCLEASE PUTATIVE
(Pyrococcus
furiosus) 		5 / 12 ILE A 296
LEU A 320
LEU A 292
ILE A 289
LEU A 326
 None
 1.27A 3a50E-1s8eA:
undetectable		 3a50E-1s8eA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 1s8e EXONUCLEASE PUTATIVE
(Pyrococcus
furiosus) 		4 / 6 LEU A 172
MET A 171
ILE A  35
ILE A  44
 None
 0.95A 3gcsA-1s8eA:
undetectable		 3gcsA-1s8eA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEH_B_DAHB786_1
(PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN)		 1s8e EXONUCLEASE PUTATIVE
(Pyrococcus
furiosus) 		4 / 7 PRO A 223
HIS A 208
GLY A 205
ALA A   7
 None
MN  A 402 (-3.6A)
None
None
 0.97A 3tehB-1s8eA:
undetectable		 3tehB-1s8eA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 1s8e EXONUCLEASE PUTATIVE
(Pyrococcus
furiosus) 		5 / 12 ILE A 306
ILE A 278
LEU A 304
LEU A 321
ILE A 296
 None
 0.84A 3uvvA-1s8eA:
0.0		 3uvvA-1s8eA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRJ_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 1s8e EXONUCLEASE PUTATIVE
(Pyrococcus
furiosus) 		5 / 12 TYR A 238
ILE A 278
VAL A 276
ILE A 328
ILE A 317
 None
 1.06A 3vrjA-1s8eA:
undetectable
3vrjC-1s8eA:
undetectable		 3vrjA-1s8eA:
20.77
3vrjC-1s8eA:
2.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1s8e EXONUCLEASE PUTATIVE
(Pyrococcus
furiosus) 		4 / 8 GLY A 142
HIS A 141
ILE A 169
PHE A  43
 None
 0.92A 4fglD-1s8eA:
undetectable		 4fglD-1s8eA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 1s8e EXONUCLEASE PUTATIVE
(Pyrococcus
furiosus) 		5 / 12 HIS A  10
HIS A 208
GLY A 224
ASP A  49
GLY A  48
 MN  A 402 (-3.4A)
MN  A 402 (-3.6A)
None
MN  A 401 ( 2.7A)
None
 1.32A 4qa0A-1s8eA:
undetectable		 4qa0A-1s8eA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_C_EPAC502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 1s8e EXONUCLEASE PUTATIVE
(Pyrococcus
furiosus) 		4 / 8 LEU A 304
ILE A 278
ALA A 288
PHE A 245
 None
 0.91A 5m0oC-1s8eA:
undetectable		 5m0oC-1s8eA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_C_ACTC301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 1s8e EXONUCLEASE PUTATIVE
(Pyrococcus
furiosus) 		5 / 6 ASP A  49
ASP A   8
HIS A  10
HIS A 208
HIS A 173
 MN  A 401 ( 2.7A)
MN  A 402 (-3.1A)
MN  A 402 (-3.4A)
MN  A 402 (-3.6A)
MN  A 401 (-3.6A)
 1.04A 5ncdB-1s8eA:
undetectable
5ncdC-1s8eA:
undetectable		 5ncdB-1s8eA:
20.06
5ncdC-1s8eA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_C_ACTC302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 1s8e EXONUCLEASE PUTATIVE
(Pyrococcus
furiosus) 		4 / 6 ASP A  49
HIS A  10
HIS A 208
HIS A 173
 MN  A 401 ( 2.7A)
MN  A 402 (-3.4A)
MN  A 402 (-3.6A)
MN  A 401 (-3.6A)
 0.95A 5nelB-1s8eA:
undetectable
5nelC-1s8eA:
undetectable		 5nelB-1s8eA:
20.06
5nelC-1s8eA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		 1s8e EXONUCLEASE PUTATIVE
(Pyrococcus
furiosus) 		4 / 8 LEU A  45
TYR A 201
VAL A 258
LEU A 204
 None
 1.02A 5v0vA-1s8eA:
undetectable		 5v0vA-1s8eA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA503_1
(CYTOCHROME P450 2C9)		 1s8e EXONUCLEASE PUTATIVE
(Pyrococcus
furiosus) 		4 / 5 PRO A  58
GLY A  59
THR A  60
LYS A  63
 None
 0.47A 5x23A-1s8eA:
0.0		 5x23A-1s8eA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA503_1
(CYTOCHROME P450 2C9)		 1s8e EXONUCLEASE PUTATIVE
(Pyrococcus
furiosus) 		4 / 6 PRO A  58
GLY A  59
THR A  60
LYS A  63
 None
 0.40A 5x24A-1s8eA:
undetectable		 5x24A-1s8eA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 1s8e EXONUCLEASE PUTATIVE
(Pyrococcus
furiosus) 		4 / 6 LEU A 192
VAL A 176
LEU A 204
VAL A 179
 None
 0.98A 5x7zA-1s8eA:
undetectable		 5x7zA-1s8eA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA502_1
(CYTOCHROME P450 2C9)		 1s8e EXONUCLEASE PUTATIVE
(Pyrococcus
furiosus) 		4 / 6 PRO A  58
GLY A  59
THR A  60
LYS A  63
 None
 0.41A 5xxiA-1s8eA:
undetectable		 5xxiA-1s8eA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1s8e EXONUCLEASE PUTATIVE
(Pyrococcus
furiosus) 		4 / 7 GLU A 212
SER A 214
VAL A 221
ARG A 183
 None
 1.32A 6av6C-1s8eA:
undetectable
6av6D-1s8eA:
undetectable		 6av6C-1s8eA:
14.47
6av6D-1s8eA:
14.47