SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1sa3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		 1sa3 TYPE II RESTRICTION
ENZYME MSPI
(Moraxella
sp.) 		4 / 8 GLN A  58
GLU A   4
ARG A   2
MET A   1
 None
 1.15A 1dtlA-1sa3A:
undetectable		 1dtlA-1sa3A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_B_DESB128_1
(TRANSTHYRETIN)		 1sa3 TYPE II RESTRICTION
ENZYME MSPI
(Moraxella
sp.) 		4 / 5 LEU A  72
ALA A  69
LEU A  67
SER A  64
 None
 0.93A 1tt6B-1sa3A:
undetectable		 1tt6B-1sa3A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1sa3 TYPE II RESTRICTION
ENZYME MSPI
(Moraxella
sp.) 		3 / 3 THR A  53
ASP A  44
SER A  82
 None
 0.83A 2nxeA-1sa3A:
undetectable		 2nxeA-1sa3A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1sa3 TYPE II RESTRICTION
ENZYME MSPI
(Moraxella
sp.) 		3 / 3 THR A  53
ASP A  44
SER A  82
 None
 0.79A 2nxeB-1sa3A:
undetectable		 2nxeB-1sa3A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)		 1sa3 TYPE II RESTRICTION
ENZYME MSPI
(Moraxella
sp.) 		5 / 10 TYR A  51
TYR A  37
ILE A  41
LEU A   6
LEU A   9
 None
 1.36A 2w98A-1sa3A:
undetectable		 2w98A-1sa3A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_C_GLYC73_0
(NONSTRUCTURAL
PROTEIN 1)		 1sa3 TYPE II RESTRICTION
ENZYME MSPI
(Moraxella
sp.) 		4 / 4 ASP A  16
ASP A  11
SER A   7
ARG A   2
 None
 1.13A 2z0aC-1sa3A:
undetectable		 2z0aC-1sa3A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_C_LEIC16_0
(COIL SER L16D-PEN)		 1sa3 TYPE II RESTRICTION
ENZYME MSPI
(Moraxella
sp.) 		4 / 6 LEU A 174
GLN A 167
LEU A 171
GLU A 146
 None
 1.08A 3h5gB-1sa3A:
undetectable
3h5gC-1sa3A:
undetectable		 3h5gB-1sa3A:
7.91
3h5gC-1sa3A:
7.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA201_1
(PROTEIN S100-A4)		 1sa3 TYPE II RESTRICTION
ENZYME MSPI
(Moraxella
sp.) 		5 / 9 GLY A 262
ILE A 136
PHE A 163
GLY A 240
PHE A 241
 None
 1.35A 3ko0A-1sa3A:
undetectable
3ko0C-1sa3A:
undetectable		 3ko0A-1sa3A:
16.03
3ko0C-1sa3A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_G_TFPG201_1
(PROTEIN S100-A4)		 1sa3 TYPE II RESTRICTION
ENZYME MSPI
(Moraxella
sp.) 		5 / 9 GLY A 240
PHE A 241
GLY A 262
ILE A 136
PHE A 163
 None
 1.39A 3ko0F-1sa3A:
undetectable
3ko0G-1sa3A:
0.1		 3ko0F-1sa3A:
16.03
3ko0G-1sa3A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_N_TFPN201_1
(PROTEIN S100-A4)		 1sa3 TYPE II RESTRICTION
ENZYME MSPI
(Moraxella
sp.) 		5 / 10 GLY A 240
PHE A 241
GLY A 262
ILE A 136
PHE A 163
 None
 1.22A 3ko0L-1sa3A:
undetectable
3ko0N-1sa3A:
undetectable		 3ko0L-1sa3A:
16.03
3ko0N-1sa3A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_R_TFPR201_1
(PROTEIN S100-A4)		 1sa3 TYPE II RESTRICTION
ENZYME MSPI
(Moraxella
sp.) 		5 / 10 GLY A 262
ILE A 136
PHE A 163
GLY A 240
PHE A 241
 None
 1.24A 3ko0R-1sa3A:
0.2
3ko0T-1sa3A:
undetectable		 3ko0R-1sa3A:
16.03
3ko0T-1sa3A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA310_1
(BETA-LACTAMASE)		 1sa3 TYPE II RESTRICTION
ENZYME MSPI
(Moraxella
sp.) 		4 / 8 LEU A 199
ALA A 100
THR A  85
GLY A  94
 None
 0.95A 3ny4A-1sa3A:
undetectable		 3ny4A-1sa3A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 1sa3 TYPE II RESTRICTION
ENZYME MSPI
(Moraxella
sp.) 		5 / 12 GLU A 232
GLY A 244
PHE A 260
ILE A 183
GLY A 242
 None
 1.22A 3ps9A-1sa3A:
undetectable		 3ps9A-1sa3A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAW_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN
SMT3,PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1sa3 TYPE II RESTRICTION
ENZYME MSPI
(Moraxella
sp.) 		5 / 11 TYR A 214
ASP A 216
ILE A  38
ILE A 219
PHE A 207
 None
 1.40A 3vawA-1sa3A:
undetectable		 3vawA-1sa3A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1sa3 TYPE II RESTRICTION
ENZYME MSPI
(Moraxella
sp.) 		4 / 8 ASP A  84
THR A  85
HIS A 200
LEU A  39
 NA  A 401 (-3.2A)
None
None
None
 1.18A 3wg7A-1sa3A:
undetectable
3wg7C-1sa3A:
0.0
3wg7P-1sa3A:
undetectable		 3wg7A-1sa3A:
18.96
3wg7C-1sa3A:
21.31
3wg7P-1sa3A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ3_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1sa3 TYPE II RESTRICTION
ENZYME MSPI
(Moraxella
sp.) 		5 / 10 TYR A 214
ASP A 216
ILE A  38
ILE A 219
PHE A 207
 None
 1.43A 4dz3A-1sa3A:
undetectable		 4dz3A-1sa3A:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAX_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)		 1sa3 TYPE II RESTRICTION
ENZYME MSPI
(Moraxella
sp.) 		5 / 10 TYR A 214
ASP A 216
ILE A  38
ILE A 219
PHE A 207
 None
 1.44A 4laxA-1sa3A:
undetectable		 4laxA-1sa3A:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NNR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2)		 1sa3 TYPE II RESTRICTION
ENZYME MSPI
(Moraxella
sp.) 		5 / 10 TYR A 214
ASP A 216
ILE A  38
ILE A 219
PHE A 207
 None
 1.39A 4nnrB-1sa3A:
undetectable		 4nnrB-1sa3A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		 1sa3 TYPE II RESTRICTION
ENZYME MSPI
(Moraxella
sp.) 		4 / 6 LEU A  72
ALA A  69
LEU A  67
SER A  64
 None
 0.98A 4pwjA-1sa3A:
undetectable		 4pwjA-1sa3A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QT2_A_RAPA202_1
(FK506-BINDING
PROTEIN (FKBP)-TYPE
PEPTIDYL-PROPYL
ISOMERASE)		 1sa3 TYPE II RESTRICTION
ENZYME MSPI
(Moraxella
sp.) 		5 / 10 TYR A 214
ASP A 216
ILE A  38
ILE A 219
PHE A 207
 None
 1.41A 4qt2A-1sa3A:
undetectable		 4qt2A-1sa3A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)		 1sa3 TYPE II RESTRICTION
ENZYME MSPI
(Moraxella
sp.) 		4 / 7 ILE A 102
LEU A  67
LEU A  48
ILE A  41
 None
 0.84A 4rmjA-1sa3A:
undetectable		 4rmjA-1sa3A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 1sa3 TYPE II RESTRICTION
ENZYME MSPI
(Moraxella
sp.) 		5 / 12 LEU A 147
ILE A 151
LYS A 257
VAL A 140
PHE A 182
 None
 1.08A 4y0qA-1sa3A:
undetectable		 4y0qA-1sa3A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1sa3 TYPE II RESTRICTION
ENZYME MSPI
(Moraxella
sp.) 		4 / 7 ILE A 142
ARG A 179
THR A 172
LEU A 171
 None
 0.98A 5b1bA-1sa3A:
0.0
5b1bJ-1sa3A:
undetectable		 5b1bA-1sa3A:
18.96
5b1bJ-1sa3A:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1sa3 TYPE II RESTRICTION
ENZYME MSPI
(Moraxella
sp.) 		3 / 3 PHE A  42
ILE A  38
ASP A  84
 None
None
NA  A 401 (-3.2A)
 0.66A 5cswA-1sa3A:
undetectable		 5cswA-1sa3A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1sa3 TYPE II RESTRICTION
ENZYME MSPI
(Moraxella
sp.) 		3 / 3 PHE A  42
ILE A  38
ASP A  84
 None
None
NA  A 401 (-3.2A)
 0.68A 5cswB-1sa3A:
undetectable		 5cswB-1sa3A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_B_PFLB407_1
(PROTON-GATED ION
CHANNEL)		 1sa3 TYPE II RESTRICTION
ENZYME MSPI
(Moraxella
sp.) 		4 / 7 TYR A  37
ILE A  41
ILE A  38
ILE A 219
 None
 0.94A 5murB-1sa3A:
undetectable		 5murB-1sa3A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 1sa3 TYPE II RESTRICTION
ENZYME MSPI
(Moraxella
sp.) 		5 / 10 TYR A 214
TYR A  37
ILE A  41
ILE A  38
ILE A 219
 None
 1.40A 5mvnD-1sa3A:
undetectable		 5mvnD-1sa3A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1sa3 TYPE II RESTRICTION
ENZYME MSPI
(Moraxella
sp.) 		4 / 6 ILE A 142
ARG A 179
THR A 172
LEU A 171
 None
 1.02A 5z86N-1sa3A:
0.0
5z86W-1sa3A:
0.0		 5z86N-1sa3A:
18.96
5z86W-1sa3A:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1sa3 TYPE II RESTRICTION
ENZYME MSPI
(Moraxella
sp.) 		4 / 8 ASP A  84
THR A  85
HIS A 200
LEU A  39
 NA  A 401 (-3.2A)
None
None
None
 1.22A 5zcoA-1sa3A:
0.0
5zcoC-1sa3A:
0.0
5zcoP-1sa3A:
undetectable		 5zcoA-1sa3A:
18.96
5zcoC-1sa3A:
21.31
5zcoP-1sa3A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1sa3 TYPE II RESTRICTION
ENZYME MSPI
(Moraxella
sp.) 		4 / 6 ILE A 142
ARG A 179
THR A 172
LEU A 171
 None
 0.99A 5zcoN-1sa3A:
0.0
5zcoW-1sa3A:
undetectable		 5zcoN-1sa3A:
18.96
5zcoW-1sa3A:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 1sa3 TYPE II RESTRICTION
ENZYME MSPI
(Moraxella
sp.) 		4 / 6 PHE A 163
LEU A 147
LEU A 150
HIS A 154
 None
 1.00A 6e43D-1sa3A:
undetectable		 6e43D-1sa3A:
20.19