SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1saw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 1saw HYPOTHETICAL PROTEIN
FLJ36880
(Homo
sapiens) 		4 / 7 LYS A 151
LEU A 150
LEU A 101
PHE A 217
 None
 0.92A 1v55P-1sawA:
undetectable
1v55W-1sawA:
undetectable		 1v55P-1sawA:
18.53
1v55W-1sawA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_A_SAMA301_0
(UPF0217 PROTEIN
AF_1056)		 1saw HYPOTHETICAL PROTEIN
FLJ36880
(Homo
sapiens) 		5 / 9 LEU A 182
GLY A  79
GLY A  95
SER A 174
CYH A  82
 None
 1.14A 2qmmA-1sawA:
undetectable		 2qmmA-1sawA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 1saw HYPOTHETICAL PROTEIN
FLJ36880
(Homo
sapiens) 		4 / 8 ASP A 102
LYS A 123
GLY A 191
GLU A  73
 MG  A 225 (-3.2A)
MG  A 225 (-3.6A)
MG  A 225 ( 4.6A)
MG  A 225 (-2.7A)
 0.81A 2ys6A-1sawA:
undetectable		 2ys6A-1sawA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC59_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1saw HYPOTHETICAL PROTEIN
FLJ36880
(Homo
sapiens) 		3 / 3 GLY A  95
GLY A 185
GLY A  79
 None
 0.38A 3bogC-1sawA:
undetectable		 3bogC-1sawA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_2
(HIV-1 PROTEASE)		 1saw HYPOTHETICAL PROTEIN
FLJ36880
(Homo
sapiens) 		5 / 10 ASP A 186
VAL A  21
ILE A 180
VAL A  23
ILE A 188
 None
 1.07A 3oxvB-1sawA:
undetectable		 3oxvB-1sawA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 1saw HYPOTHETICAL PROTEIN
FLJ36880
(Homo
sapiens) 		4 / 8 VAL A  21
CYH A 129
ILE A 188
PHE A  13
 None
 0.67A 3wzeA-1sawA:
undetectable		 3wzeA-1sawA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 1saw HYPOTHETICAL PROTEIN
FLJ36880
(Homo
sapiens) 		5 / 9 MET A 165
ILE A 172
ILE A 169
MET A  91
ILE A 188
 None
 1.14A 3zosA-1sawA:
undetectable		 3zosA-1sawA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OU1_A_BEZA302_0
(RETRO-ALDOLASE,
DESIGN RA114)		 1saw HYPOTHETICAL PROTEIN
FLJ36880
(Homo
sapiens) 		4 / 8 ILE A 187
ILE A  20
ALA A  51
TRP A  14
 None
 0.89A 4ou1A-1sawA:
undetectable		 4ou1A-1sawA:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 1saw HYPOTHETICAL PROTEIN
FLJ36880
(Homo
sapiens) 		4 / 7 LEU A 148
ILE A 173
MET A  91
MET A 165
 None
 1.29A 5ljcA-1sawA:
undetectable		 5ljcA-1sawA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1saw HYPOTHETICAL PROTEIN
FLJ36880
(Homo
sapiens) 		4 / 5 TYR A  52
VAL A  43
MET A  78
GLY A 185
 None
 1.32A 6hd4A-1sawA:
undetectable		 6hd4A-1sawA:
18.89