SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1sb3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		5 / 9 GLY A 284
HIS A 282
ALA A 312
THR A 351
THR A 679
 None
 1.45A 1c9sL-1sb3A:
0.0
1c9sM-1sb3A:
0.0		 1c9sL-1sb3A:
7.84
1c9sM-1sb3A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_M_TRPM81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		5 / 9 GLY A 284
HIS A 282
ALA A 312
THR A 351
THR A 679
 None
 1.44A 1c9sM-1sb3A:
0.0
1c9sN-1sb3A:
0.0		 1c9sM-1sb3A:
7.84
1c9sN-1sb3A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_R_TRPR81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		5 / 9 GLY A 284
HIS A 282
ALA A 312
THR A 351
THR A 679
 None
 1.42A 1c9sR-1sb3A:
0.0
1c9sS-1sb3A:
0.0		 1c9sR-1sb3A:
7.84
1c9sS-1sb3A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_S_TRPS81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		5 / 9 GLY A 284
HIS A 282
ALA A 312
THR A 351
THR A 679
 None
 1.42A 1c9sS-1sb3A:
0.0
1c9sT-1sb3A:
0.0		 1c9sS-1sb3A:
7.84
1c9sT-1sb3A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
4-HYDROXYBENZOYL-COA
REDUCTASE GAMMA
SUBUNIT
(Thauera
aromatica;
Thauera
aromatica) 		5 / 10 GLY A  26
GLU C 112
ARG C 116
LEU C  52
GLU C  74
 None
 1.13A 1cmcA-1sb3A:
undetectable
1cmcB-1sb3A:
undetectable		 1cmcA-1sb3A:
8.82
1cmcB-1sb3A:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT
(Thauera
aromatica) 		4 / 7 LEU B 252
ALA B 240
LEU B 242
SER B 219
 None
 1.01A 1dvxA-1sb3B:
undetectable		 1dvxA-1sb3B:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_2
(TRANSTHYRETIN)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT
(Thauera
aromatica) 		4 / 7 LEU B 252
ALA B 240
LEU B 242
SER B 219
 None
 0.98A 1dvxB-1sb3B:
undetectable		 1dvxB-1sb3B:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4002_1
(SERUM ALBUMIN)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		4 / 5 ALA A 110
ALA A 119
LYS A 118
GLU A 117
 None
 1.13A 1e7cA-1sb3A:
undetectable		 1e7cA-1sb3A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_E_ESTE600_1
(ESTROGEN RECEPTOR)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT
(Thauera
aromatica) 		4 / 8 MET B 168
ALA B 174
LEU B 207
LEU B 112
 None
None
FAD  B1900 (-4.6A)
None
 0.96A 1ereE-1sb3B:
undetectable		 1ereE-1sb3B:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_F_ESTF600_1
(ESTROGEN RECEPTOR)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT
(Thauera
aromatica) 		4 / 8 MET B 168
ALA B 174
LEU B 207
LEU B 112
 None
None
FAD  B1900 (-4.6A)
None
 0.96A 1ereF-1sb3B:
undetectable		 1ereF-1sb3B:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FIQ_C_SALC1335_1
(XANTHINE OXIDASE)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE GAMMA
SUBUNIT
(Thauera
aromatica) 		4 / 8 LEU C   5
THR C  31
VAL C  32
LEU C  28
 None
 0.87A 1fiqC-1sb3C:
undetectable		 1fiqC-1sb3C:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_M_TRPM81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		5 / 9 GLY A 284
HIS A 282
ALA A 312
THR A 351
THR A 679
 None
 1.46A 1gtfM-1sb3A:
0.0
1gtfN-1sb3A:
0.0		 1gtfM-1sb3A:
7.84
1gtfN-1sb3A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		5 / 8 GLY A 284
HIS A 282
ALA A 312
THR A 351
THR A 679
 None
 1.46A 1gtfN-1sb3A:
undetectable
1gtfO-1sb3A:
undetectable		 1gtfN-1sb3A:
7.84
1gtfO-1sb3A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		5 / 9 GLY A 284
HIS A 282
ALA A 312
THR A 351
THR A 679
 None
 1.49A 1gtfO-1sb3A:
undetectable
1gtfP-1sb3A:
0.0		 1gtfO-1sb3A:
7.84
1gtfP-1sb3A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		5 / 10 GLY A 284
HIS A 282
ALA A 312
THR A 351
THR A 679
 None
 1.45A 1gtfP-1sb3A:
0.0
1gtfQ-1sb3A:
0.0		 1gtfP-1sb3A:
7.84
1gtfQ-1sb3A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		5 / 9 GLY A 284
HIS A 282
ALA A 312
THR A 351
THR A 679
 None
 1.49A 1gtnQ-1sb3A:
undetectable
1gtnR-1sb3A:
undetectable		 1gtnQ-1sb3A:
7.84
1gtnR-1sb3A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_R_TRPR81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		5 / 9 GLY A 284
HIS A 282
ALA A 312
THR A 351
THR A 679
 None
 1.48A 1gtnR-1sb3A:
undetectable
1gtnS-1sb3A:
0.0		 1gtnR-1sb3A:
7.84
1gtnS-1sb3A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_S_TRPS81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		5 / 9 GLY A 284
HIS A 282
ALA A 312
THR A 351
THR A 679
 None
 1.44A 1gtnS-1sb3A:
undetectable
1gtnT-1sb3A:
undetectable		 1gtnS-1sb3A:
7.84
1gtnT-1sb3A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_1
(TRANSTHYRETIN)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT
(Thauera
aromatica) 		4 / 6 LEU B 252
ALA B 240
LEU B 242
SER B 219
 None
 0.81A 1ictB-1sb3B:
undetectable		 1ictB-1sb3B:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_B_VIBB501_1
(THIAMIN
PYROPHOSPHOKINASE)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT
(Thauera
aromatica) 		4 / 7 LEU B 309
SER B 259
SER B 261
ASN B 260
 None
 1.25A 1ig3A-1sb3B:
undetectable
1ig3B-1sb3B:
undetectable		 1ig3A-1sb3B:
23.56
1ig3B-1sb3B:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		5 / 11 ILE A 736
LEU A 733
GLY A 731
PHE A 732
ALA A 368
 None
 1.25A 1ju6A-1sb3A:
undetectable		 1ju6A-1sb3A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		5 / 10 ILE A 736
LEU A 733
GLY A 731
PHE A 732
ALA A 368
 None
 1.25A 1ju6C-1sb3A:
undetectable		 1ju6C-1sb3A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA154_1
(CALMODULIN)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE GAMMA
SUBUNIT
(Thauera
aromatica) 		4 / 7 LEU C  88
GLU C 112
LEU C  52
GLU C  74
 None
 1.06A 1linA-1sb3C:
undetectable		 1linA-1sb3C:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWF_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		5 / 9 LEU A 544
VAL A 499
VAL A 561
GLY A 498
LEU A 466
 None
 1.06A 1lwfA-1sb3A:
0.0		 1lwfA-1sb3A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_B_SAMB400_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
4-HYDROXYBENZOYL-COA
REDUCTASE GAMMA
SUBUNIT
(Thauera
aromatica;
Thauera
aromatica) 		5 / 9 GLU C 112
ARG C 116
LEU C  52
GLU C  74
GLY A  26
 None
 1.09A 1mjlA-1sb3C:
undetectable
1mjlB-1sb3C:
undetectable		 1mjlA-1sb3C:
23.78
1mjlB-1sb3C:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_D_SAMD200_0
(METHIONINE REPRESSOR)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
4-HYDROXYBENZOYL-COA
REDUCTASE GAMMA
SUBUNIT
(Thauera
aromatica;
Thauera
aromatica) 		5 / 12 GLY A  26
GLU C 112
ARG C 116
LEU C  52
GLU C  74
 None
 1.12A 1mjqC-1sb3A:
undetectable
1mjqD-1sb3A:
undetectable		 1mjqC-1sb3A:
8.53
1mjqD-1sb3A:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_J_SAMJ200_0
(METHIONINE REPRESSOR)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
4-HYDROXYBENZOYL-COA
REDUCTASE GAMMA
SUBUNIT
(Thauera
aromatica;
Thauera
aromatica) 		5 / 12 GLY A  26
GLU C 112
ARG C 116
LEU C  52
GLU C  74
 None
 1.11A 1mjqI-1sb3A:
undetectable
1mjqJ-1sb3A:
undetectable		 1mjqI-1sb3A:
8.53
1mjqJ-1sb3A:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_1
(POL POLYPROTEIN)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		5 / 8 ASP A  19
ILE A 481
GLY A 243
GLY A 242
PRO A 239
 None
PCD  A1920 (-4.2A)
PCD  A1920 (-3.4A)
None
None
 1.16A 1sguA-1sb3A:
undetectable		 1sguA-1sb3A:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_A_9CRA131_1
(TRANSTHYRETIN)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT
(Thauera
aromatica) 		4 / 6 LEU B 252
ALA B 240
LEU B 242
SER B 219
 None
 0.85A 1tyrA-1sb3B:
undetectable		 1tyrA-1sb3B:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_B_9CRB130_1
(TRANSTHYRETIN)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT
(Thauera
aromatica) 		4 / 7 LEU B 252
ALA B 240
LEU B 242
SER B 219
 None
 0.88A 1tyrB-1sb3B:
0.0		 1tyrB-1sb3B:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT
(Thauera
aromatica) 		4 / 6 LEU B 252
ALA B 240
LEU B 242
SER B 219
 None
 0.86A 1tz8C-1sb3B:
undetectable
1tz8D-1sb3B:
undetectable		 1tz8C-1sb3B:
16.72
1tz8D-1sb3B:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_N_TRPN81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		5 / 10 GLY A 284
HIS A 282
ALA A 312
THR A 351
THR A 679
 None
 1.45A 1utdN-1sb3A:
0.0
1utdO-1sb3A:
0.0		 1utdN-1sb3A:
7.84
1utdO-1sb3A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_B_P1ZB2001_1
(SERUM ALBUMIN)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT
(Thauera
aromatica) 		5 / 9 LEU A 692
ARG B 228
HIS B 106
ARG B 107
ALA B 230
 FAD  B1900 ( 4.2A)
None
FAD  B1900 ( 4.7A)
None
None
 1.34A 2bxcB-1sb3A:
0.0		 2bxcB-1sb3A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2001_1
(SERUM ALBUMIN)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE GAMMA
SUBUNIT
(Thauera
aromatica) 		5 / 10 ALA C  48
ALA C  60
ARG C  58
LEU C  24
LEU C  28
 FES  C1908 ( 4.7A)
None
None
None
None
 1.13A 2bxqA-1sb3C:
2.5		 2bxqA-1sb3C:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CC8_A_RBFA1067_1
(VNG1446H)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT
(Thauera
aromatica) 		3 / 3 PHE B 124
VAL A 687
TRP B 131
 SF4  B1910 ( 4.9A)
None
None
 0.74A 2cc8A-1sb3B:
0.2		 2cc8A-1sb3B:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CCB_A_RBFA1067_1
(VNG1446H)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT
(Thauera
aromatica) 		3 / 3 PHE B 124
VAL A 687
TRP B 131
 SF4  B1910 ( 4.9A)
None
None
 0.75A 2ccbA-1sb3B:
0.0		 2ccbA-1sb3B:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_B_CHDB701_0
(FERROCHELATASE)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT
(Thauera
aromatica) 		3 / 3 LYS B 224
GLY B 103
PRO B 104
 FAD  B1900 (-2.8A)
None
None
 1.01A 2hreB-1sb3B:
undetectable		 2hreB-1sb3B:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		5 / 12 ALA A 532
SER A 533
ALA A 489
PRO A 515
GLY A 596
 None
 1.10A 2igtB-1sb3A:
undetectable		 2igtB-1sb3A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		5 / 12 ALA A 532
SER A 533
ALA A 489
PRO A 515
GLY A 596
 None
 1.09A 2igtC-1sb3A:
undetectable		 2igtC-1sb3A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		3 / 3 ALA A 509
GLY A 519
SER A 485
 None
 0.53A 2ivuA-1sb3A:
undetectable		 2ivuA-1sb3A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_1
(MINERALOCORTICOID
RECEPTOR)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		5 / 12 LEU A 441
ALA A 440
LEU A 385
LEU A 437
PHE A 732
 None
 1.26A 2oaxF-1sb3A:
undetectable		 2oaxF-1sb3A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCU_A_TYLA3001_1
(LACTOTRANSFERRIN)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		3 / 3 LEU A 221
TYR A 217
GLY A 519
 None
 0.49A 2ocuA-1sb3A:
undetectable		 2ocuA-1sb3A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_A_CLUA808_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		4 / 7 ALA A 315
TYR A 100
ASP A 103
HIS A 148
 None
 1.47A 2pncA-1sb3A:
undetectable		 2pncA-1sb3A:
23.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		4 / 8 ILE A 534
ASP A 714
GLY A 720
PHE A 719
 None
 0.94A 2tsrB-1sb3A:
undetectable		 2tsrB-1sb3A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_B_REAB1445_1
(PUTATIVE CYTOCHROME
P450 120)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		5 / 12 THR A 365
ALA A 730
ALA A 440
GLY A 333
GLN A 404
 None
 1.18A 2ve3B-1sb3A:
undetectable		 2ve3B-1sb3A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VX9_A_RBFA1064_1
(DODECIN)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT
(Thauera
aromatica) 		3 / 3 PHE B 124
VAL A 687
TRP B 131
 SF4  B1910 ( 4.9A)
None
None
 0.73A 2vx9A-1sb3B:
0.2		 2vx9A-1sb3B:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT
(Thauera
aromatica) 		4 / 5 TYR B 159
PRO B 234
ASN B 115
LEU B  78
 None
None
FAD  B1900 (-3.2A)
FAD  B1900 (-4.7A)
 1.36A 2wekA-1sb3B:
0.0		 2wekA-1sb3B:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT
(Thauera
aromatica) 		4 / 6 TYR B 159
PRO B 234
ASN B 115
LEU B  78
 None
None
FAD  B1900 (-3.2A)
FAD  B1900 (-4.7A)
 1.31A 2wekB-1sb3B:
undetectable		 2wekB-1sb3B:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		3 / 3 ARG A 405
GLU A 603
SER A 712
 None
 0.87A 2xctD-1sb3A:
undetectable		 2xctD-1sb3A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE GAMMA
SUBUNIT
(Thauera
aromatica) 		4 / 8 THR C  75
ARG C 116
LEU C  24
ASP C  16
 None
 1.03A 2zw9A-1sb3C:
undetectable		 2zw9A-1sb3C:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB4_0
(FERROCHELATASE)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE GAMMA
SUBUNIT
(Thauera
aromatica) 		4 / 6 ARG C  29
PRO C  57
GLY C 106
MET C 109
 None
 1.42A 3aqiB-1sb3C:
undetectable		 3aqiB-1sb3C:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_A_DIFA1_1
(TRANSTHYRETIN)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT
(Thauera
aromatica) 		4 / 6 LEU B 252
ALA B 240
LEU B 242
SER B 219
 None
 0.95A 3cfqA-1sb3B:
undetectable		 3cfqA-1sb3B:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_B_DIFB1_1
(TRANSTHYRETIN)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT
(Thauera
aromatica) 		4 / 7 LEU B 252
ALA B 240
LEU B 242
SER B 219
 None
 0.83A 3cfqA-1sb3B:
undetectable
3cfqB-1sb3B:
undetectable		 3cfqA-1sb3B:
17.08
3cfqB-1sb3B:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_A_1FLA502_1
(TRANSTHYRETIN)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT
(Thauera
aromatica) 		4 / 7 LEU B 252
ALA B 240
LEU B 242
SER B 219
 None
 0.87A 3d2tA-1sb3B:
undetectable		 3d2tA-1sb3B:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_B_SAMB600_0
(PCZA361.24)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		5 / 12 GLY A 637
LEU A 753
LEU A 761
SER A 631
GLY A 434
 None
 1.02A 3g2oB-1sb3A:
undetectable		 3g2oB-1sb3A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB0_A_DIFA701_1
(LACTOTRANSFERRIN)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		4 / 4 PRO A  92
TYR A  91
GLY A  74
THR A  73
 None
 1.46A 3ib0A-1sb3A:
undetectable		 3ib0A-1sb3A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
4-HYDROXYBENZOYL-COA
REDUCTASE GAMMA
SUBUNIT
(Thauera
aromatica) 		4 / 8 GLY A  26
CYH C  46
CYH C 135
PHE A 245
 None
FES  C1908 (-2.2A)
FES  C1907 (-2.3A)
PCD  A1920 (-3.4A)
 1.08A 3ko0D-1sb3A:
undetectable
3ko0E-1sb3A:
undetectable		 3ko0D-1sb3A:
7.84
3ko0E-1sb3A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD202_1
(PROTEIN S100-A4)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		5 / 11 GLU A 580
LEU A 576
SER A 577
PHE A 566
PHE A 468
 None
 1.30A 3ko0C-1sb3A:
undetectable
3ko0D-1sb3A:
undetectable
3ko0E-1sb3A:
undetectable
3ko0F-1sb3A:
undetectable		 3ko0C-1sb3A:
7.84
3ko0D-1sb3A:
7.84
3ko0E-1sb3A:
7.84
3ko0F-1sb3A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF202_1
(PROTEIN S100-A4)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		5 / 11 GLU A 580
LEU A 576
SER A 577
PHE A 566
PHE A 468
 None
 1.19A 3ko0E-1sb3A:
undetectable
3ko0F-1sb3A:
undetectable
3ko0G-1sb3A:
undetectable
3ko0H-1sb3A:
undetectable		 3ko0E-1sb3A:
7.84
3ko0F-1sb3A:
7.84
3ko0G-1sb3A:
7.84
3ko0H-1sb3A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
4-HYDROXYBENZOYL-COA
REDUCTASE GAMMA
SUBUNIT
(Thauera
aromatica) 		4 / 8 GLY A  26
CYH C  46
CYH C 135
PHE A 245
 None
FES  C1908 (-2.2A)
FES  C1907 (-2.3A)
PCD  A1920 (-3.4A)
 1.09A 3ko0B-1sb3A:
undetectable
3ko0J-1sb3A:
undetectable		 3ko0B-1sb3A:
7.84
3ko0J-1sb3A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO202_1
(PROTEIN S100-A4)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		5 / 11 LEU A 576
SER A 577
PHE A 566
PHE A 468
GLU A 580
 None
 1.34A 3ko0O-1sb3A:
undetectable
3ko0P-1sb3A:
undetectable
3ko0Q-1sb3A:
0.0
3ko0R-1sb3A:
undetectable		 3ko0O-1sb3A:
7.84
3ko0P-1sb3A:
7.84
3ko0Q-1sb3A:
7.84
3ko0R-1sb3A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_A_URFA254_1
(URIDINE
PHOSPHORYLASE)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
4-HYDROXYBENZOYL-COA
REDUCTASE GAMMA
SUBUNIT
(Thauera
aromatica) 		4 / 6 GLY C 139
GLN C  99
ILE A 705
VAL C 141
 None
PCD  A1920 ( 4.0A)
None
None
 1.14A 3kvvA-1sb3C:
undetectable		 3kvvA-1sb3C:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_B_URFB254_1
(URIDINE
PHOSPHORYLASE)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
4-HYDROXYBENZOYL-COA
REDUCTASE GAMMA
SUBUNIT
(Thauera
aromatica) 		4 / 6 GLY C 139
GLN C  99
ILE A 705
VAL C 141
 None
PCD  A1920 ( 4.0A)
None
None
 1.12A 3kvvB-1sb3C:
undetectable		 3kvvB-1sb3C:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_C_URFC254_1
(URIDINE
PHOSPHORYLASE)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
4-HYDROXYBENZOYL-COA
REDUCTASE GAMMA
SUBUNIT
(Thauera
aromatica) 		4 / 6 GLY C 139
GLN C  99
ILE A 705
VAL C 141
 None
PCD  A1920 ( 4.0A)
None
None
 1.15A 3kvvC-1sb3C:
undetectable		 3kvvC-1sb3C:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_D_URFD254_1
(URIDINE
PHOSPHORYLASE)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
4-HYDROXYBENZOYL-COA
REDUCTASE GAMMA
SUBUNIT
(Thauera
aromatica) 		4 / 6 GLY C 139
GLN C  99
ILE A 705
VAL C 141
 None
PCD  A1920 ( 4.0A)
None
None
 1.14A 3kvvD-1sb3C:
undetectable		 3kvvD-1sb3C:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_E_URFE254_1
(URIDINE
PHOSPHORYLASE)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
4-HYDROXYBENZOYL-COA
REDUCTASE GAMMA
SUBUNIT
(Thauera
aromatica) 		4 / 6 GLY C 139
GLN C  99
ILE A 705
VAL C 141
 None
PCD  A1920 ( 4.0A)
None
None
 1.14A 3kvvE-1sb3C:
undetectable		 3kvvE-1sb3C:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_F_URFF254_1
(URIDINE
PHOSPHORYLASE)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
4-HYDROXYBENZOYL-COA
REDUCTASE GAMMA
SUBUNIT
(Thauera
aromatica) 		4 / 6 GLY C 139
GLN C  99
ILE A 705
VAL C 141
 None
PCD  A1920 ( 4.0A)
None
None
 1.12A 3kvvF-1sb3C:
undetectable		 3kvvF-1sb3C:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_A_KKKA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		5 / 12 TYR A 218
GLY A 246
ALA A 356
THR A 323
ILE A  86
 None
PCD  A1920 (-3.2A)
PCD  A1920 ( 4.2A)
None
None
 1.26A 3ld6A-1sb3A:
undetectable		 3ld6A-1sb3A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		4 / 7 TYR A 348
VAL A 129
ILE A 145
ARG A 101
 None
 0.96A 3mssB-1sb3A:
undetectable		 3mssB-1sb3A:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_B_SAMB220_0
(16S RRNA METHYLASE)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT
(Thauera
aromatica) 		5 / 12 GLY B 258
GLY B 237
ALA B 262
GLU B 193
LEU B 235
 None
 1.03A 3mteB-1sb3B:
undetectable		 3mteB-1sb3B:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_2
(FIV PROTEASE)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		5 / 10 LEU A 474
ILE A 592
VAL A 594
VAL A 462
LEU A 464
 None
 0.97A 3ogpB-1sb3A:
undetectable		 3ogpB-1sb3A:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_B_T44B128_1
(TRANSTHYRETIN)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT
(Thauera
aromatica) 		4 / 7 LEU B 252
ALA B 240
LEU B 242
SER B 219
 None
 0.82A 3ozkB-1sb3B:
0.0		 3ozkB-1sb3B:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		5 / 11 ALA A 356
TYR A 217
ASN A 518
THR A 448
VAL A 445
 PCD  A1920 ( 4.2A)
None
None
None
None
 1.04A 3rukD-1sb3A:
undetectable		 3rukD-1sb3A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_C_C2FC1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		3 / 3 ARG A 285
PRO A 734
PHE A 183
 None
 0.75A 3thrC-1sb3A:
undetectable		 3thrC-1sb3A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B17_A_SAMA1358_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		5 / 12 GLY A 284
PRO A 353
GLY A 314
GLY A 313
MET A 357
 None
 1.12A 4b17A-1sb3A:
undetectable		 4b17A-1sb3A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT
(Thauera
aromatica) 		4 / 7 LEU B 252
ALA B 240
LEU B 242
SER B 219
 None
 0.79A 4d7bA-1sb3B:
undetectable		 4d7bA-1sb3B:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_B_MTXB162_1
(DIHYDROFOLATE
REDUCTASE)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT
(Thauera
aromatica) 		5 / 12 ALA B  97
LEU B 167
ILE B  72
LEU B  70
ILE B  87
 None
 1.08A 4dfrB-1sb3B:
undetectable		 4dfrB-1sb3B:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_F_URFF1301_1
(URIDINE
PHOSPHORYLASE)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
4-HYDROXYBENZOYL-COA
REDUCTASE GAMMA
SUBUNIT
(Thauera
aromatica) 		4 / 6 GLY C 139
GLN C  99
ILE A 705
VAL C 141
 None
PCD  A1920 ( 4.0A)
None
None
 1.11A 4e1vF-1sb3C:
undetectable		 4e1vF-1sb3C:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUB_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		3 / 3 TYR A 316
ARG A 283
HIS A 253
 None
 1.02A 4fubA-1sb3A:
undetectable		 4fubA-1sb3A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_A_1FLA201_1
(TRANSTHYRETIN)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT
(Thauera
aromatica) 		4 / 6 LEU B 252
ALA B 240
LEU B 242
SER B 219
 None
 0.90A 4i89A-1sb3B:
undetectable		 4i89A-1sb3B:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_2
(MEMBRANE LIPOPROTEIN
TPN38(B))		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT
4-HYDROXYBENZOYL-COA
REDUCTASE GAMMA
SUBUNIT
(Thauera
aromatica) 		5 / 8 PRO B  29
ASN B  39
PRO B  38
GLN C  67
GLN B 118
 FAD  B1900 (-3.6A)
None
None
None
FAD  B1900 (-3.2A)
 1.37A 4iilA-1sb3B:
undetectable		 4iilA-1sb3B:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_B_IMNB201_1
(TRANSTHYRETIN)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT
(Thauera
aromatica) 		4 / 8 LEU B 252
ALA B 240
LEU B 242
SER B 219
 None
 0.82A 4ik7B-1sb3B:
undetectable		 4ik7B-1sb3B:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT
(Thauera
aromatica) 		4 / 6 LEU B 252
ALA B 240
LEU B 242
SER B 219
 None
 0.87A 4ikiB-1sb3B:
undetectable		 4ikiB-1sb3B:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_A_SUZA201_1
(TRANSTHYRETIN)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT
(Thauera
aromatica) 		4 / 7 LEU B 252
ALA B 240
LEU B 242
SER B 219
 None
 0.96A 4ikjA-1sb3B:
undetectable
4ikjB-1sb3B:
undetectable		 4ikjA-1sb3B:
16.72
4ikjB-1sb3B:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_B_SUZB201_1
(TRANSTHYRETIN)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT
(Thauera
aromatica) 		4 / 8 LEU B 252
ALA B 240
LEU B 242
SER B 219
 None
 0.87A 4ikjA-1sb3B:
undetectable
4ikjB-1sb3B:
undetectable		 4ikjA-1sb3B:
16.72
4ikjB-1sb3B:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_A_SUZA201_1
(TRANSTHYRETIN)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT
(Thauera
aromatica) 		4 / 8 LEU B 252
ALA B 240
LEU B 242
SER B 219
 None
 0.86A 4ikkA-1sb3B:
undetectable
4ikkB-1sb3B:
undetectable		 4ikkA-1sb3B:
16.72
4ikkB-1sb3B:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_B_SUZB201_1
(TRANSTHYRETIN)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT
(Thauera
aromatica) 		4 / 7 LEU B 252
ALA B 240
LEU B 242
SER B 219
 None
 0.95A 4ikkA-1sb3B:
undetectable
4ikkB-1sb3B:
undetectable		 4ikkA-1sb3B:
16.72
4ikkB-1sb3B:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		4 / 7 ILE A 534
ASP A 714
GLY A 720
PHE A 719
 None
 0.89A 4iqqA-1sb3A:
undetectable		 4iqqA-1sb3A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		4 / 8 ILE A 534
ASP A 714
GLY A 720
PHE A 719
 None
 0.88A 4iqqD-1sb3A:
undetectable		 4iqqD-1sb3A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_F_CAMF502_0
(CAMPHOR
5-MONOOXYGENASE)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		4 / 4 TYR A 402
THR A 327
VAL A 159
ILE A 615
 None
 1.39A 4jx1F-1sb3A:
0.0		 4jx1F-1sb3A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		3 / 3 GLY A 606
GLU A 603
THR A 602
 None
 0.56A 4kouA-1sb3A:
undetectable		 4kouA-1sb3A:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		5 / 12 ILE A 758
VAL A 639
LEU A 753
VAL A 628
ALA A 739
 None
 1.03A 4m11C-1sb3A:
0.0		 4m11C-1sb3A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT
(Thauera
aromatica) 		3 / 3 ARG A  46
TRP B 130
ILE A 280
 None
 0.85A 4mwxA-1sb3A:
undetectable		 4mwxA-1sb3A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		4 / 6 THR A  10
LEU A 474
LEU A 540
GLU A 539
 None
 1.14A 4nc3A-1sb3A:
undetectable		 4nc3A-1sb3A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		3 / 3 ALA A 421
GLN A 664
GLY A 661
 None
 0.55A 4odoC-1sb3A:
undetectable		 4odoC-1sb3A:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT
(Thauera
aromatica) 		4 / 6 LEU B 252
ALA B 240
LEU B 242
SER B 219
 None
 0.92A 4pwjA-1sb3B:
undetectable		 4pwjA-1sb3B:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_1
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		4 / 4 THR A 448
GLY A 519
ASP A 517
SER A 522
 None
 1.24A 4rfqA-1sb3A:
undetectable		 4rfqA-1sb3A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		4 / 5 ILE A 709
VAL A 707
PHE A 732
CYH A 622
 None
 1.26A 4rzvA-1sb3A:
0.0		 4rzvA-1sb3A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V20_A_ACTA1444_0
(CELLOBIOHYDROLASE)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		4 / 5 GLY A 246
THR A 249
HIS A 188
GLY A 355
 PCD  A1920 (-3.2A)
PCD  A1920 (-3.8A)
None
None
 1.10A 4v20A-1sb3A:
undetectable		 4v20A-1sb3A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
4-HYDROXYBENZOYL-COA
REDUCTASE GAMMA
SUBUNIT
(Thauera
aromatica;
Thauera
aromatica) 		5 / 12 GLY C  43
LEU C  59
ASN A 690
MET A 191
ARG C 136
 None
FES  C1908 ( 4.2A)
None
None
None
 1.28A 4x61A-1sb3C:
undetectable		 4x61A-1sb3C:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB401_0
(GLYCINE OXIDASE)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		4 / 6 PHE A 163
LYS A 341
TYR A 402
ALA A 329
 None
 1.32A 4yshB-1sb3A:
undetectable		 4yshB-1sb3A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z7F_C_FOLC201_0
(FOLATE ECF
TRANSPORTER)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		5 / 12 ALA A  28
ASN A 194
THR A 212
LEU A 241
ARG A 248
 None
 1.27A 4z7fC-1sb3A:
0.0		 4z7fC-1sb3A:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		5 / 8 LEU A 415
VAL A 418
ALA A 625
LEU A 441
GLY A 410
 None
 1.26A 4zauA-1sb3A:
undetectable		 4zauA-1sb3A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE0_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		5 / 9 THR A  59
GLY A  74
THR A  77
LEU A 260
LEU A 261
 None
 1.27A 4ze0A-1sb3A:
undetectable		 4ze0A-1sb3A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT
(Thauera
aromatica) 		4 / 6 LEU B 252
ALA B 240
LEU B 242
SER B 219
 None
 0.96A 5a6iA-1sb3B:
0.0		 5a6iA-1sb3B:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT
(Thauera
aromatica) 		4 / 6 LEU B 252
ALA B 240
LEU B 242
SER B 219
 None
 0.93A 5bojA-1sb3B:
undetectable		 5bojA-1sb3B:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		5 / 9 THR A 679
GLY A 284
HIS A 282
ALA A 312
THR A 351
 None
 1.47A 5eeuL-1sb3A:
0.0
5eeuV-1sb3A:
0.0		 5eeuL-1sb3A:
7.84
5eeuV-1sb3A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_N_TRPN101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		5 / 9 GLY A 284
HIS A 282
ALA A 312
THR A 351
THR A 679
 None
 1.47A 5eeuM-1sb3A:
0.0
5eeuN-1sb3A:
0.0		 5eeuM-1sb3A:
7.84
5eeuN-1sb3A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		5 / 10 GLY A 284
HIS A 282
ALA A 312
THR A 351
THR A 679
 None
 1.45A 5eeuP-1sb3A:
undetectable
5eeuQ-1sb3A:
0.0		 5eeuP-1sb3A:
7.84
5eeuQ-1sb3A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_N_TRPN101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		5 / 9 GLY A 284
HIS A 282
ALA A 312
THR A 351
THR A 679
 None
 1.48A 5eevM-1sb3A:
0.0
5eevN-1sb3A:
0.0		 5eevM-1sb3A:
7.84
5eevN-1sb3A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		5 / 10 GLY A 284
HIS A 282
ALA A 312
THR A 351
THR A 679
 None
 1.47A 5eevT-1sb3A:
0.0
5eevU-1sb3A:
undetectable		 5eevT-1sb3A:
7.84
5eevU-1sb3A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_N_TRPN101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		5 / 9 GLY A 284
HIS A 282
ALA A 312
THR A 351
THR A 679
 None
 1.48A 5eewM-1sb3A:
0.0
5eewN-1sb3A:
0.0		 5eewM-1sb3A:
7.84
5eewN-1sb3A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		5 / 9 THR A 679
GLY A 284
HIS A 282
ALA A 312
THR A 351
 None
 1.48A 5eexL-1sb3A:
0.0
5eexV-1sb3A:
0.0		 5eexL-1sb3A:
7.84
5eexV-1sb3A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_N_TRPN101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		5 / 9 GLY A 284
HIS A 282
ALA A 312
THR A 351
THR A 679
 None
 1.48A 5eexM-1sb3A:
0.0
5eexN-1sb3A:
undetectable		 5eexM-1sb3A:
7.84
5eexN-1sb3A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		5 / 10 GLY A 284
HIS A 282
ALA A 312
THR A 351
THR A 679
 None
 1.46A 5eexP-1sb3A:
0.0
5eexQ-1sb3A:
0.0		 5eexP-1sb3A:
7.84
5eexQ-1sb3A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		5 / 9 THR A 679
GLY A 284
HIS A 282
ALA A 312
THR A 351
 None
 1.48A 5eeyL-1sb3A:
undetectable
5eeyV-1sb3A:
0.0		 5eeyL-1sb3A:
7.84
5eeyV-1sb3A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_N_TRPN101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		5 / 9 GLY A 284
HIS A 282
ALA A 312
THR A 351
THR A 679
 None
 1.48A 5eeyM-1sb3A:
0.0
5eeyN-1sb3A:
0.0		 5eeyM-1sb3A:
7.84
5eeyN-1sb3A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		5 / 10 GLY A 284
HIS A 282
ALA A 312
THR A 351
THR A 679
 None
 1.46A 5eeyP-1sb3A:
undetectable
5eeyQ-1sb3A:
0.0		 5eeyP-1sb3A:
7.84
5eeyQ-1sb3A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		5 / 8 THR A 679
GLY A 284
HIS A 282
ALA A 312
THR A 351
 None
 1.48A 5eezL-1sb3A:
undetectable
5eezV-1sb3A:
undetectable		 5eezL-1sb3A:
7.84
5eezV-1sb3A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_N_TRPN101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		5 / 9 GLY A 284
HIS A 282
ALA A 312
THR A 351
THR A 679
 None
 1.48A 5eezM-1sb3A:
0.0
5eezN-1sb3A:
0.0		 5eezM-1sb3A:
7.84
5eezN-1sb3A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		5 / 10 GLY A 284
HIS A 282
ALA A 312
THR A 351
THR A 679
 None
 1.46A 5eezP-1sb3A:
0.0
5eezQ-1sb3A:
undetectable		 5eezP-1sb3A:
7.84
5eezQ-1sb3A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		5 / 9 THR A 679
GLY A 284
HIS A 282
ALA A 312
THR A 351
 None
 1.48A 5ef0L-1sb3A:
0.0
5ef0V-1sb3A:
0.0		 5ef0L-1sb3A:
7.84
5ef0V-1sb3A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_N_TRPN101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		5 / 9 GLY A 284
HIS A 282
ALA A 312
THR A 351
THR A 679
 None
 1.48A 5ef0M-1sb3A:
0.0
5ef0N-1sb3A:
0.0		 5ef0M-1sb3A:
7.84
5ef0N-1sb3A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		5 / 10 GLY A 284
HIS A 282
ALA A 312
THR A 351
THR A 679
 None
 1.46A 5ef0P-1sb3A:
0.0
5ef0Q-1sb3A:
undetectable		 5ef0P-1sb3A:
7.84
5ef0Q-1sb3A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		5 / 8 THR A 679
GLY A 284
HIS A 282
ALA A 312
THR A 351
 None
 1.48A 5ef1L-1sb3A:
undetectable
5ef1V-1sb3A:
undetectable		 5ef1L-1sb3A:
7.84
5ef1V-1sb3A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_N_TRPN101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		5 / 9 GLY A 284
HIS A 282
ALA A 312
THR A 351
THR A 679
 None
 1.48A 5ef1M-1sb3A:
0.0
5ef1N-1sb3A:
0.0		 5ef1M-1sb3A:
7.84
5ef1N-1sb3A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		5 / 8 THR A 679
GLY A 284
HIS A 282
ALA A 312
THR A 351
 None
 1.48A 5ef2L-1sb3A:
undetectable
5ef2V-1sb3A:
undetectable		 5ef2L-1sb3A:
7.84
5ef2V-1sb3A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_N_TRPN101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		5 / 9 GLY A 284
HIS A 282
ALA A 312
THR A 351
THR A 679
 None
 1.49A 5ef2M-1sb3A:
0.0
5ef2N-1sb3A:
undetectable		 5ef2M-1sb3A:
7.84
5ef2N-1sb3A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_N_TRPN101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		5 / 9 GLY A 284
HIS A 282
ALA A 312
THR A 351
THR A 679
 None
 1.49A 5ef3M-1sb3A:
0.0
5ef3N-1sb3A:
0.0		 5ef3M-1sb3A:
7.84
5ef3N-1sb3A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		5 / 10 GLY A 284
HIS A 282
ALA A 312
THR A 351
THR A 679
 None
 1.48A 5ef3T-1sb3A:
undetectable
5ef3U-1sb3A:
undetectable		 5ef3T-1sb3A:
7.84
5ef3U-1sb3A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
4-HYDROXYBENZOYL-COA
REDUCTASE GAMMA
SUBUNIT
(Thauera
aromatica;
Thauera
aromatica) 		5 / 12 GLY C  43
LEU C  59
ASN A 690
MET A 191
ARG C 136
 None
FES  C1908 ( 4.2A)
None
None
None
 1.28A 5emlA-1sb3C:
undetectable		 5emlA-1sb3C:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		4 / 4 ALA A  94
PRO A 353
LEU A 156
HIS A 148
 None
 1.27A 5eskA-1sb3A:
undetectable		 5eskA-1sb3A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G08_A_Z80A1187_1
(FREQUENIN 2)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		4 / 6 ILE A 280
PHE A 279
PHE A 254
THR A 212
 None
 1.36A 5g08A-1sb3A:
2.0		 5g08A-1sb3A:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_A_D16A401_1
(ORF70)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		4 / 7 ILE A 534
ASP A 714
GLY A 720
PHE A 719
 None
 0.87A 5h3aA-1sb3A:
undetectable		 5h3aA-1sb3A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_A_IPHA101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT
(Thauera
aromatica) 		4 / 4 CYH B 117
LEU B 207
LEU B 190
ALA B 174
 FAD  B1900 (-3.5A)
FAD  B1900 (-4.6A)
None
None
 0.82A 5hpuA-1sb3B:
undetectable
5hpuB-1sb3B:
undetectable		 5hpuA-1sb3B:
6.31
5hpuB-1sb3B:
7.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		5 / 12 ALA A 281
GLY A 320
GLY A 284
GLY A  82
VAL A  83
 None
 0.92A 5i73A-1sb3A:
undetectable		 5i73A-1sb3A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_2
(ENVELOPE
GLYCOPROTEIN 2)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		4 / 7 LEU A 207
THR A 211
THR A 212
LEU A 227
 None
 0.85A 5jq7B-1sb3A:
0.0		 5jq7B-1sb3A:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_O_ASCO1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT
(Thauera
aromatica;
Thauera
aromatica) 		4 / 7 HIS A 688
ILE A 280
TYR A 681
GLN B 127
 None
 1.27A 5kkzM-1sb3A:
undetectable
5kkzO-1sb3A:
undetectable		 5kkzM-1sb3A:
15.27
5kkzO-1sb3A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT
(Thauera
aromatica) 		4 / 6 LEU B 252
ALA B 240
LEU B 242
SER B 219
 None
 0.95A 5l4iA-1sb3B:
undetectable		 5l4iA-1sb3B:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MM4_B_TA1B501_1
(TUBULIN BETA CHAIN)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		5 / 10 VAL A 159
HIS A 342
ALA A 161
PHE A 163
THR A 400
 None
 1.23A 5mm4B-1sb3A:
undetectable		 5mm4B-1sb3A:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		4 / 5 TYR A 326
SER A 613
ALA A 614
THR A 450
 None
None
EPE  A1111 ( 4.1A)
EPE  A1111 ( 4.6A)
 1.08A 5n4iA-1sb3A:
undetectable		 5n4iA-1sb3A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_A_BEZA507_0
(BETA-LACTAMASE VIM-2)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		3 / 3 THR A 450
HIS A 459
ASN A 518
 EPE  A1111 ( 4.6A)
EPE  A1111 (-4.7A)
None
 0.98A 5n4tA-1sb3A:
undetectable		 5n4tA-1sb3A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		4 / 8 ILE A 534
ASP A 714
GLY A 720
PHE A 719
 None
 0.87A 5nooD-1sb3A:
0.0		 5nooD-1sb3A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT
4-HYDROXYBENZOYL-COA
REDUCTASE GAMMA
SUBUNIT
(Thauera
aromatica;
Thauera
aromatica) 		4 / 7 LEU C 130
GLY C 132
GLY B 103
ALA C 110
 None
 0.75A 5o96C-1sb3C:
undetectable		 5o96C-1sb3C:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PHH_A_LDPA414_1
(LYSINE-SPECIFIC
DEMETHYLASE 4D)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		4 / 6 GLU A 192
ARG A 248
ALA A 195
LEU A 193
 None
 1.16A 5phhA-1sb3A:
undetectable		 5phhA-1sb3A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH8_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		3 / 3 CYH A 600
MET A 528
ASN A 531
 None
 1.29A 5qh8A-1sb3A:
0.2		 5qh8A-1sb3A:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE GAMMA
SUBUNIT
(Thauera
aromatica) 		4 / 4 LEU C  88
LEU C 115
SER C 146
ALA C 151
 None
 1.12A 5uunA-1sb3C:
undetectable		 5uunA-1sb3C:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT
4-HYDROXYBENZOYL-COA
REDUCTASE GAMMA
SUBUNIT
(Thauera
aromatica;
Thauera
aromatica) 		3 / 3 LEU C  64
ALA C  65
LEU B  37
 None
 0.54A 5uunB-1sb3C:
undetectable		 5uunB-1sb3C:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_B_CHDB301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
4-HYDROXYBENZOYL-COA
REDUCTASE GAMMA
SUBUNIT
(Thauera
aromatica;
Thauera
aromatica) 		5 / 11 ARG A 358
GLY A 243
GLY A 484
GLN C  99
THR C  98
 PCD  A1920 (-3.8A)
PCD  A1920 (-3.4A)
PCD  A1920 (-3.7A)
PCD  A1920 ( 4.0A)
None
 1.41A 5w97G-1sb3A:
0.0
5w97a-1sb3A:
0.0
5w97b-1sb3A:
0.0		 5w97G-1sb3A:
7.68
5w97a-1sb3A:
22.04
5w97b-1sb3A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGQ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT
(Thauera
aromatica) 		5 / 9 ALA B 174
LEU B 190
ARG B 183
GLY B 114
LEU B 112
 None
None
None
FAD  B1900 (-3.3A)
None
 1.49A 5wgqA-1sb3B:
0.0		 5wgqA-1sb3B:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT
(Thauera
aromatica) 		5 / 12 ALA B  97
LEU B 167
ILE B  72
LEU B  70
ILE B  87
 None
 1.00A 5z6kA-1sb3B:
undetectable		 5z6kA-1sb3B:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
4-HYDROXYBENZOYL-COA
REDUCTASE GAMMA
SUBUNIT
(Thauera
aromatica) 		4 / 5 GLN C  99
THR C  98
THR C 149
LEU A 657
 PCD  A1920 ( 4.0A)
None
None
None
 1.21A 6aphA-1sb3C:
undetectable		 6aphA-1sb3C:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_E_HISE402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE GAMMA
SUBUNIT
(Thauera
aromatica) 		5 / 9 LEU C  25
GLY C 106
THR C  75
VAL C  51
CYH C  49
 None
None
None
None
FES  C1908 (-2.3A)
 1.31A 6czmD-1sb3C:
undetectable
6czmE-1sb3C:
undetectable		 6czmD-1sb3C:
20.18
6czmE-1sb3C:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECF_I_DVAI3010_0
(VLM2
DODECADEPSIPEPTIDE)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
4-HYDROXYBENZOYL-COA
REDUCTASE GAMMA
SUBUNIT
(Thauera
aromatica;
Thauera
aromatica) 		3 / 3 PHE C 102
ARG C  29
ALA A 195
 None
 0.84A 6ecfB-1sb3C:
undetectable		 6ecfB-1sb3C:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_A_ADNA502_2
(-)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
4-HYDROXYBENZOYL-COA
REDUCTASE GAMMA
SUBUNIT
(Thauera
aromatica) 		4 / 4 GLN C  99
THR C  98
THR C 149
LEU A 657
 PCD  A1920 ( 4.0A)
None
None
None
 1.22A 6f3mA-1sb3C:
undetectable		 6f3mA-1sb3C:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_C_ADNC502_2
(-)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
4-HYDROXYBENZOYL-COA
REDUCTASE GAMMA
SUBUNIT
(Thauera
aromatica) 		4 / 4 GLN C  99
THR C  98
THR C 149
LEU A 657
 PCD  A1920 ( 4.0A)
None
None
None
 1.24A 6f3mC-1sb3C:
undetectable		 6f3mC-1sb3C:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_L_ZOLL401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
4-HYDROXYBENZOYL-COA
REDUCTASE GAMMA
SUBUNIT
(Thauera
aromatica;
Thauera
aromatica) 		4 / 6 ASP A 480
ASP A  19
GLN C  99
LYS A  23
 None
None
PCD  A1920 ( 4.0A)
None
 1.33A 6g31L-1sb3A:
undetectable		 6g31L-1sb3A:
6.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_2
(-)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
4-HYDROXYBENZOYL-COA
REDUCTASE GAMMA
SUBUNIT
(Thauera
aromatica) 		4 / 5 GLN C  99
THR C  98
THR C 149
LEU A 657
 PCD  A1920 ( 4.0A)
None
None
None
 1.22A 6gbnB-1sb3C:
undetectable		 6gbnB-1sb3C:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		5 / 12 GLY A 665
GLY A 666
VAL A 363
GLN A 626
GLY A 727
 None
 1.10A 6gneA-1sb3A:
undetectable		 6gneA-1sb3A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		5 / 12 GLY A 665
GLY A 666
VAL A 363
GLN A 626
GLY A 727
 None
 1.09A 6gneB-1sb3A:
undetectable		 6gneB-1sb3A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
4-HYDROXYBENZOYL-COA
REDUCTASE GAMMA
SUBUNIT
(Thauera
aromatica;
Thauera
aromatica) 		4 / 6 LEU A 241
CYH C 100
GLY A 244
ARG A 248
 None
FES  C1907 (-2.1A)
PCD  A1920 (-3.6A)
None
 1.19A 6gtqB-1sb3A:
undetectable
6gtqD-1sb3A:
undetectable		 6gtqB-1sb3A:
12.95
6gtqD-1sb3A:
5.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT
(Thauera
aromatica;
Thauera
aromatica) 		4 / 7 VAL B 316
ILE A 635
GLY B 301
ALA B 236
 None
 0.84A 6hd6B-1sb3B:
undetectable		 6hd6B-1sb3B:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_K_BO2K301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT
(Thauera
aromatica) 		6 / 11 THR B  54
ALA B 109
THR B  77
ALA B 108
GLY B  31
GLY B  33
 None
None
None
None
FAD  B1900 (-3.1A)
FAD  B1900 (-3.3A)
 1.43A 6hwdK-1sb3B:
undetectable
6hwdL-1sb3B:
undetectable		 6hwdK-1sb3B:
13.44
6hwdL-1sb3B:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_Y_BO2Y301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT
(Thauera
aromatica) 		6 / 11 THR B  54
ALA B 109
THR B  77
ALA B 108
GLY B  31
GLY B  33
 None
None
None
None
FAD  B1900 (-3.1A)
FAD  B1900 (-3.3A)
 1.43A 6hwdY-1sb3B:
undetectable
6hwdZ-1sb3B:
undetectable		 6hwdY-1sb3B:
13.44
6hwdZ-1sb3B:
14.02