SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1sb7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NCW_H_BEZH601_0
(IMMUNOGLOBULIN IGG2A)		 1sb7 TRNA PSEUDOURIDINE
SYNTHASE D
(Escherichia
coli) 		5 / 9 ALA A 326
ASN A 129
TRP A 323
LEU A 126
GLY A  34
 None
 1.44A 1ncwH-1sb7A:
1.8
1ncwL-1sb7A:
1.8		 1ncwH-1sb7A:
19.95
1ncwL-1sb7A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUA_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 1sb7 TRNA PSEUDOURIDINE
SYNTHASE D
(Escherichia
coli) 		5 / 10 ALA A 326
ASN A 129
TRP A 323
LEU A 126
GLY A  34
 None
 1.45A 1ruaH-1sb7A:
0.0
1ruaL-1sb7A:
0.0		 1ruaH-1sb7A:
19.95
1ruaL-1sb7A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 1sb7 TRNA PSEUDOURIDINE
SYNTHASE D
(Escherichia
coli) 		5 / 8 ALA A 326
ASN A 129
TRP A 323
LEU A 126
GLY A  34
 None
 1.43A 1rukH-1sb7A:
undetectable
1rukL-1sb7A:
undetectable		 1rukH-1sb7A:
19.95
1rukL-1sb7A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUL_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 1sb7 TRNA PSEUDOURIDINE
SYNTHASE D
(Escherichia
coli) 		5 / 9 ALA A 326
ASN A 129
TRP A 323
LEU A 126
GLY A  34
 None
 1.45A 1rulH-1sb7A:
0.0
1rulL-1sb7A:
undetectable		 1rulH-1sb7A:
19.95
1rulL-1sb7A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUM_H_BEZH1601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 1sb7 TRNA PSEUDOURIDINE
SYNTHASE D
(Escherichia
coli) 		5 / 9 ALA A 326
ASN A 129
TRP A 323
LEU A 126
GLY A  34
 None
 1.43A 1rumH-1sb7A:
0.0
1rumL-1sb7A:
1.8		 1rumH-1sb7A:
19.95
1rumL-1sb7A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUP_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 1sb7 TRNA PSEUDOURIDINE
SYNTHASE D
(Escherichia
coli) 		5 / 9 ALA A 326
ASN A 129
TRP A 323
LEU A 126
GLY A  34
 None
 1.43A 1rupH-1sb7A:
1.8
1rupL-1sb7A:
1.8		 1rupH-1sb7A:
19.95
1rupL-1sb7A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1320_0
(CHLOROPEROXIDASE)		 1sb7 TRNA PSEUDOURIDINE
SYNTHASE D
(Escherichia
coli) 		4 / 6 ALA A 330
PHE A 322
VAL A  29
PHE A  27
 GOL  A1203 (-3.7A)
None
None
GOL  A1203 (-4.3A)
 0.81A 2cizA-1sb7A:
0.0		 2cizA-1sb7A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_D_ADND504_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 1sb7 TRNA PSEUDOURIDINE
SYNTHASE D
(Escherichia
coli) 		3 / 3 PHE A 160
ASN A 204
PHE A 165
 None
 0.88A 2zbuD-1sb7A:
undetectable		 2zbuD-1sb7A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA424_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1sb7 TRNA PSEUDOURIDINE
SYNTHASE D
(Escherichia
coli) 		4 / 8 ARG A 247
PRO A 325
SER A 328
GLY A 229
 None
 1.00A 3hcrA-1sb7A:
undetectable		 3hcrA-1sb7A:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_2
(MEMBRANE LIPOPROTEIN
TPN38(B))		 1sb7 TRNA PSEUDOURIDINE
SYNTHASE D
(Escherichia
coli) 		4 / 8 VAL A 207
ASN A 158
GLN A 226
ILE A 255
 None
None
GOL  A1202 ( 4.7A)
None
 0.79A 4iilA-1sb7A:
undetectable		 4iilA-1sb7A:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M48_A_21BA704_1
(TRANSPORTER)		 1sb7 TRNA PSEUDOURIDINE
SYNTHASE D
(Escherichia
coli) 		4 / 8 VAL A  46
TYR A 114
SER A 102
ALA A  91
 None
 0.93A 4m48A-1sb7A:
undetectable		 4m48A-1sb7A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_2
(EPHRIN TYPE-A
RECEPTOR 2)		 1sb7 TRNA PSEUDOURIDINE
SYNTHASE D
(Escherichia
coli) 		3 / 3 ILE A  44
ILE A  68
MET A  98
 None
 0.69A 5i9yA-1sb7A:
undetectable		 5i9yA-1sb7A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_E_SAME501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1sb7 TRNA PSEUDOURIDINE
SYNTHASE D
(Escherichia
coli) 		5 / 9 LEU A 308
GLY A 155
SER A 309
LEU A 148
ARG A 147
 None
 1.45A 5o96E-1sb7A:
undetectable
5o96F-1sb7A:
undetectable		 5o96E-1sb7A:
19.68
5o96F-1sb7A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_0
(ALPHA-AMYLASE)		 1sb7 TRNA PSEUDOURIDINE
SYNTHASE D
(Escherichia
coli) 		5 / 12 TYR A 304
LEU A 302
MET A 301
ASP A 215
GLN A 218
 None
 1.31A 6ag0C-1sb7A:
undetectable		 6ag0C-1sb7A:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECF_I_DVAI3010_0
(VLM2
DODECADEPSIPEPTIDE)		 1sb7 TRNA PSEUDOURIDINE
SYNTHASE D
(Escherichia
coli) 		3 / 3 PHE A 234
ARG A 247
ALA A 228
 None
 0.98A 6ecfB-1sb7A:
undetectable		 6ecfB-1sb7A:
25.54