SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1sb8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_2
(PROTEIN (ADENOSINE
KINASE))		 1sb8 WBPP
(Pseudomonas
aeruginosa) 		3 / 3 LEU A 316
SER A 311
ASN A 262
 None
 0.79A 1bx4A-1sb8A:
5.2		 1bx4A-1sb8A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1sb8 WBPP
(Pseudomonas
aeruginosa) 		5 / 10 THR A 269
PHE A 236
ASN A 272
VAL A 224
TYR A 295
 None
 1.13A 1claA-1sb8A:
undetectable		 1claA-1sb8A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 1sb8 WBPP
(Pseudomonas
aeruginosa) 		4 / 7 HIS A  53
GLY A  52
ALA A  25
GLU A  59
 None
NAD  A 342 (-2.9A)
NAD  A 342 (-4.2A)
None
 0.81A 1dmaA-1sb8A:
undetectable		 1dmaA-1sb8A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_E_CCSE47_0
(GLUTATHIONE
S-TRANSFERASE)		 1sb8 WBPP
(Pseudomonas
aeruginosa) 		4 / 7 THR A  35
LEU A  33
GLY A  29
LEU A  96
 None
 0.95A 1gtiE-1sb8A:
undetectable		 1gtiE-1sb8A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 1sb8 WBPP
(Pseudomonas
aeruginosa) 		4 / 6 ASN A 118
HIS A  97
ALA A 100
GLY A 102
 None
None
NAD  A 342 (-2.9A)
UD2  A 343 ( 3.9A)
 1.11A 1l7xA-1sb8A:
2.4		 1l7xA-1sb8A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 1sb8 WBPP
(Pseudomonas
aeruginosa) 		4 / 6 ASN A 118
HIS A  97
ALA A 100
GLY A 102
 None
None
NAD  A 342 (-2.9A)
UD2  A 343 ( 3.9A)
 1.12A 1l7xB-1sb8A:
0.7		 1l7xB-1sb8A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_1
(PROTEASE)		 1sb8 WBPP
(Pseudomonas
aeruginosa) 		4 / 7 ASP A 235
ILE A 239
PRO A 212
ALA A 209
 None
None
None
UD2  A 343 (-3.6A)
 0.76A 1n49A-1sb8A:
undetectable		 1n49A-1sb8A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBK_A_RAPA225_1
(FKBP25)		 1sb8 WBPP
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  36
GLY A  23
ILE A  28
TYR A 193
ILE A 263
 None
NAD  A 342 (-3.4A)
NAD  A 342 (-3.7A)
NAD  A 342 ( 4.6A)
None
 0.93A 1pbkA-1sb8A:
undetectable		 1pbkA-1sb8A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2001_1
(SERUM ALBUMIN)		 1sb8 WBPP
(Pseudomonas
aeruginosa) 		4 / 8 ALA A  50
PHE A  49
ALA A  25
LEU A  57
 NAD  A 342 (-4.1A)
None
NAD  A 342 (-4.2A)
None
 0.89A 2bxmA-1sb8A:
undetectable		 2bxmA-1sb8A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1sb8 WBPP
(Pseudomonas
aeruginosa) 		5 / 12 THR A 269
GLN A 273
ILE A 226
VAL A 224
ALA A 277
 None
None
UD2  A 343 (-4.7A)
None
None
 0.98A 2g72B-1sb8A:
5.5		 2g72B-1sb8A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		 1sb8 WBPP
(Pseudomonas
aeruginosa) 		5 / 11 ILE A 310
ALA A 314
ARG A   9
GLU A 240
LEU A 248
 None
 1.29A 2v0mD-1sb8A:
0.0		 2v0mD-1sb8A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)		 1sb8 WBPP
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  23
GLY A  29
ASN A  31
ARG A 200
ILE A  79
 NAD  A 342 (-3.4A)
None
None
None
NAD  A 342 (-3.9A)
 1.09A 3ihtA-1sb8A:
4.0		 3ihtA-1sb8A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHN_A_ACTA108_0
(PROTEIN P-30)		 1sb8 WBPP
(Pseudomonas
aeruginosa) 		3 / 3 THR A 232
SER A 233
ARG A 234
 UD2  A 343 (-4.1A)
None
UD2  A 343 (-3.7A)
 0.80A 3phnA-1sb8A:
undetectable		 3phnA-1sb8A:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QJ7_A_SPMA264_1
(THYMIDYLATE SYNTHASE)		 1sb8 WBPP
(Pseudomonas
aeruginosa) 		4 / 8 ALA A 256
GLN A 259
LEU A 317
TYR A 261
 None
 0.84A 3qj7A-1sb8A:
undetectable
3qj7D-1sb8A:
undetectable		 3qj7A-1sb8A:
23.12
3qj7D-1sb8A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_D_DXCD92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1sb8 WBPP
(Pseudomonas
aeruginosa) 		4 / 5 VAL A  24
GLU A 240
LYS A  38
PHE A  72
 None
 1.25A 3rv5C-1sb8A:
0.0
3rv5D-1sb8A:
0.0		 3rv5C-1sb8A:
13.65
3rv5D-1sb8A:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1sb8 WBPP
(Pseudomonas
aeruginosa) 		5 / 12 ARG A 279
GLY A 328
ALA A 330
ALA A 277
ASP A 280
 None
 1.09A 3sugA-1sb8A:
undetectable		 3sugA-1sb8A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1sb8 WBPP
(Pseudomonas
aeruginosa) 		4 / 7 GLY A  23
THR A  22
ILE A  21
THR A 242
 NAD  A 342 (-3.4A)
None
None
None
 0.68A 4acaC-1sb8A:
5.8		 4acaC-1sb8A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_A_NCAA1536_0
(DIPHTHERIA TOXIN)		 1sb8 WBPP
(Pseudomonas
aeruginosa) 		4 / 6 HIS A  53
GLY A  52
ALA A  25
GLU A  59
 None
NAD  A 342 (-2.9A)
NAD  A 342 (-4.2A)
None
 0.74A 4ae1A-1sb8A:
undetectable		 4ae1A-1sb8A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_1
(METHYLTRANSFERASE
NSUN4)		 1sb8 WBPP
(Pseudomonas
aeruginosa) 		3 / 3 ASP A  78
ARG A  80
ASP A  47
 NAD  A 342 (-3.2A)
None
NAD  A 342 (-2.8A)
 0.78A 4fp9A-1sb8A:
7.0		 4fp9A-1sb8A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1sb8 WBPP
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 198
ALA A 332
PHE A 236
LEU A 274
THR A 215
 None
 1.16A 4hytA-1sb8A:
3.5		 4hytA-1sb8A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_C_OBNC2004_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1sb8 WBPP
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 198
ALA A 332
PHE A 236
LEU A 274
THR A 215
 None
 1.17A 4hytC-1sb8A:
undetectable		 4hytC-1sb8A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA304_1
(CHITOSANASE)		 1sb8 WBPP
(Pseudomonas
aeruginosa) 		4 / 4 TYR A 336
ILE A 211
THR A 215
TYR A 238
 None
 1.37A 4oltA-1sb8A:
0.0		 4oltA-1sb8A:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB304_1
(CHITOSANASE)		 1sb8 WBPP
(Pseudomonas
aeruginosa) 		4 / 5 TYR A 336
ILE A 211
THR A 215
TYR A 238
 None
 1.31A 4oltB-1sb8A:
0.0		 4oltB-1sb8A:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA303_1
(CHITOSANASE)		 1sb8 WBPP
(Pseudomonas
aeruginosa) 		4 / 6 TYR A 336
ILE A 211
THR A 215
TYR A 238
 None
 1.36A 4qwpA-1sb8A:
0.0		 4qwpA-1sb8A:
26.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB302_1
(CHITOSANASE)		 1sb8 WBPP
(Pseudomonas
aeruginosa) 		4 / 5 TYR A 336
ILE A 211
THR A 215
TYR A 238
 None
 1.34A 4qwpB-1sb8A:
0.0		 4qwpB-1sb8A:
26.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 1sb8 WBPP
(Pseudomonas
aeruginosa) 		4 / 5 LEU A 317
VAL A 265
TYR A 261
ARG A 199
 None
 1.10A 4r7iA-1sb8A:
undetectable		 4r7iA-1sb8A:
26.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		 1sb8 WBPP
(Pseudomonas
aeruginosa) 		4 / 6 SER A 306
LEU A 307
ASP A 235
LEU A 152
 UD2  A 343 (-3.4A)
None
None
None
 0.72A 4wozA-1sb8A:
2.8
4wozB-1sb8A:
2.8		 4wozA-1sb8A:
22.52
4wozB-1sb8A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNV_A_BEZA304_0
(SHKAI2IB)		 1sb8 WBPP
(Pseudomonas
aeruginosa) 		4 / 5 GLN A  98
ILE A  28
ILE A 239
TYR A 193
 None
NAD  A 342 (-3.7A)
None
NAD  A 342 ( 4.6A)
 1.26A 5dnvA-1sb8A:
4.8		 5dnvA-1sb8A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)		 1sb8 WBPP
(Pseudomonas
aeruginosa) 		4 / 6 ASN A 241
TYR A 323
VAL A 265
VAL A 325
 None
 1.14A 6f32B-1sb8A:
4.0		 6f32B-1sb8A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_A_CXQA507_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 1sb8 WBPP
(Pseudomonas
aeruginosa) 		4 / 5 ARG A 192
ALA A 141
TYR A 139
ILE A 189
 None
 1.31A 6f6sA-1sb8A:
0.0
6f6sB-1sb8A:
undetectable		 6f6sA-1sb8A:
13.81
6f6sB-1sb8A:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 1sb8 WBPP
(Pseudomonas
aeruginosa) 		4 / 8 ASP A  78
ILE A  79
ARG A  80
ASN A 173
 NAD  A 342 (-3.2A)
NAD  A 342 (-3.9A)
None
None
 1.25A 6hisC-1sb8A:
0.0
6hisD-1sb8A:
0.0		 6hisC-1sb8A:
13.35
6hisD-1sb8A:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 1sb8 WBPP
(Pseudomonas
aeruginosa) 		4 / 8 ASN A 173
ASP A  78
ILE A  79
ARG A  80
 None
NAD  A 342 (-3.2A)
NAD  A 342 (-3.9A)
None
 1.26A 6hisA-1sb8A:
0.0
6hisE-1sb8A:
0.0		 6hisA-1sb8A:
13.35
6hisE-1sb8A:
13.35