SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1sbq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A99_D_MIYD393_1 (TETX2 PROTEIN)	1sbq	5,10-METHENYLTETRAHY DROFOLATE SYNTHETASE HOMOLOG (Mycoplasma pneumoniae)	4 / 5	ILE A 99 ILE A 84 TYR A 126 GLU A 83	None	1.23A	4a99D-1sbqA: undetectable	4a99D-1sbqA: 22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A99_D_MIYD393_1 (TETX2 PROTEIN)	1sbq	5,10-METHENYLTETRAHY DROFOLATE SYNTHETASE HOMOLOG (Mycoplasma pneumoniae)	4 / 5	ILE A 99 ILE A 85 TYR A 126 GLU A 83	None	1.18A	4a99D-1sbqA: undetectable	4a99D-1sbqA: 22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WG0_L_CHDL103_0 (NUCLEAR RECEPTOR COACTIVATOR 2)	1sbq	5,10-METHENYLTETRAHY DROFOLATE SYNTHETASE HOMOLOG (Mycoplasma pneumoniae)	4 / 7	ASN A 30 LEU A 33 LEU A 37 LEU A 103	None	0.76A	4wg0L-1sbqA: undetectable 4wg0M-1sbqA: undetectable	4wg0L-1sbqA: 6.35 4wg0M-1sbqA: 6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HLO_A_GBQA1501_1 (SUBSTANCE-P RECEPTOR,GLGA GLYCOGEN SYNTHASE,SUBSTANCE-P RECEPTOR)	1sbq	5,10-METHENYLTETRAHY DROFOLATE SYNTHETASE HOMOLOG (Mycoplasma pneumoniae)	5 / 9	ILE A 29 ILE A 161 GLU A 21 VAL A 56 ILE A 139	None	1.44A	6hloA-1sbqA: undetectable	6hloA-1sbqA: 15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HLP_A_GAWA1501_0 (SUBSTANCE-P RECEPTOR,SUBSTANCE-P RECEPTOR)	1sbq	5,10-METHENYLTETRAHY DROFOLATE SYNTHETASE HOMOLOG (Mycoplasma pneumoniae)	5 / 12	ILE A 29 ILE A 161 VAL A 56 ILE A 139 PHE A 109	None	1.13A	6hlpA-1sbqA: undetectable	6hlpA-1sbqA: 15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6NKN_J_CHDJ101_0 (CYTOCHROME C OXIDASE SUBUNIT 3 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	1sbq	5,10-METHENYLTETRAHY DROFOLATE SYNTHETASE HOMOLOG (Mycoplasma pneumoniae)	3 / 3	ARG A 7 PHE A 109 PHE A 118	None	1.08A	6nknC-1sbqA: undetectable 6nknJ-1sbqA: undetectable	6nknC-1sbqA: 20.45 6nknJ-1sbqA: 17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6NMP_P_CHDP307_0 (CYTOCHROME C OXIDASE SUBUNIT 3 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	1sbq	5,10-METHENYLTETRAHY DROFOLATE SYNTHETASE HOMOLOG (Mycoplasma pneumoniae)	4 / 5	ARG A 7 LEU A 116 PHE A 109 PHE A 118	None	1.35A	6nmpP-1sbqA: undetectable 6nmpW-1sbqA: undetectable	6nmpP-1sbqA: 20.45 6nmpW-1sbqA: 17.22

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4A99_D_MIYD393_1","TETX2 PROTEIN","1sbq","5,10-METHENYLTETRAHYDROFOLATE SYNTHETASE HOMOLOG","Mycoplasma pneumoniae",4,"ILE A  99;ILE A  84;TYR A 126;GLU A  83","None","1.23A","4a99D-1sbqA:undetectable","4a99D-1sbqA:22.31"],["4A99_D_MIYD393_1","TETX2 PROTEIN","1sbq","5,10-METHENYLTETRAHYDROFOLATE SYNTHETASE HOMOLOG","Mycoplasma pneumoniae",4,"ILE A  99;ILE A  85;TYR A 126;GLU A  83","None","1.18A","4a99D-1sbqA:undetectable","4a99D-1sbqA:22.31"],["4WG0_L_CHDL103_0","NUCLEAR RECEPTOR COACTIVATOR 2","1sbq","5,10-METHENYLTETRAHYDROFOLATE SYNTHETASE HOMOLOG","Mycoplasma pneumoniae",4,"ASN A  30;LEU A  33;LEU A  37;LEU A 103","None","0.76A","4wg0L-1sbqA:undetectable;4wg0M-1sbqA:undetectable","4wg0L-1sbqA:6.35;4wg0M-1sbqA:6.35"],["6HLO_A_GBQA1501_1","SUBSTANCE-P RECEPTOR,GLGA GLYCOGEN SYNTHASE,SUBSTANCE-P RECEPTOR","1sbq","5,10-METHENYLTETRAHYDROFOLATE SYNTHETASE HOMOLOG","Mycoplasma pneumoniae",5,"ILE A  29;ILE A 161;GLU A  21;VAL A  56;ILE A 139","None","1.44A","6hloA-1sbqA:undetectable","6hloA-1sbqA:15.75"],["6HLP_A_GAWA1501_0","SUBSTANCE-P RECEPTOR,SUBSTANCE-P RECEPTOR","1sbq","5,10-METHENYLTETRAHYDROFOLATE SYNTHETASE HOMOLOG","Mycoplasma pneumoniae",5,"ILE A  29;ILE A 161;VAL A  56;ILE A 139;PHE A 109","None","1.13A","6hlpA-1sbqA:undetectable","6hlpA-1sbqA:15.75"],["6NKN_J_CHDJ101_0","CYTOCHROME C OXIDASE SUBUNIT 3;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","1sbq","5,10-METHENYLTETRAHYDROFOLATE SYNTHETASE HOMOLOG","Mycoplasma pneumoniae",3,"ARG A   7;PHE A 109;PHE A 118","None","1.08A","6nknC-1sbqA:undetectable;6nknJ-1sbqA:undetectable","6nknC-1sbqA:20.45;6nknJ-1sbqA:17.22"],["6NMP_P_CHDP307_0","CYTOCHROME C OXIDASE SUBUNIT 3;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","1sbq","5,10-METHENYLTETRAHYDROFOLATE SYNTHETASE HOMOLOG","Mycoplasma pneumoniae",4,"ARG A   7;LEU A 116;PHE A 109;PHE A 118","None","1.35A","6nmpP-1sbqA:undetectable;6nmpW-1sbqA:undetectable","6nmpP-1sbqA:20.45;6nmpW-1sbqA:17.22"]]