SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1sbz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XL6_B_SPMB3001_1
(INWARD RECTIFIER
POTASSIUM CHANNEL)		 1sbz PROBABLE AROMATIC
ACID DECARBOXYLASE
(Escherichia
coli) 		4 / 5 ALA A  96
TYR A  98
ALA A  92
GLN A  67
 None
 0.97A 1xl6A-1sbzA:
undetectable
1xl6B-1sbzA:
undetectable		 1xl6A-1sbzA:
20.98
1xl6B-1sbzA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_B_P1ZB2001_1
(SERUM ALBUMIN)		 1sbz PROBABLE AROMATIC
ACID DECARBOXYLASE
(Escherichia
coli) 		5 / 9 GLU A 132
LEU A 119
LEU A  91
ALA A  96
ALA A 136
 None
 1.46A 2bxcB-1sbzA:
undetectable		 2bxcB-1sbzA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		 1sbz PROBABLE AROMATIC
ACID DECARBOXYLASE
(Escherichia
coli) 		4 / 6 ILE A  94
ARG A  95
LEU A  91
LEU A 111
 None
 1.07A 2rlfA-1sbzA:
undetectable
2rlfD-1sbzA:
undetectable		 2rlfA-1sbzA:
14.02
2rlfD-1sbzA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_B_DIFB1_1
(TRANSTHYRETIN)		 1sbz PROBABLE AROMATIC
ACID DECARBOXYLASE
(Escherichia
coli) 		4 / 7 SER A  87
LYS A  40
ALA A  39
THR A   8
 FMN  A1401 (-2.6A)
None
None
FMN  A1401 (-3.2A)
 0.90A 3cfqA-1sbzA:
undetectable
3cfqB-1sbzA:
undetectable		 3cfqA-1sbzA:
22.11
3cfqB-1sbzA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELW_A_SAMA4633_0
(METHYLTRANSFERASE)		 1sbz PROBABLE AROMATIC
ACID DECARBOXYLASE
(Escherichia
coli) 		5 / 12 GLY A  16
GLY A  12
LEU A  23
PHE A 173
ILE A  82
 None
 0.92A 3elwA-1sbzA:
undetectable		 3elwA-1sbzA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)		 1sbz PROBABLE AROMATIC
ACID DECARBOXYLASE
(Escherichia
coli) 		3 / 3 MET A 134
CYH A  86
PRO A 146
 None
 1.22A 3h52C-1sbzA:
undetectable		 3h52C-1sbzA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1sbz PROBABLE AROMATIC
ACID DECARBOXYLASE
(Escherichia
coli) 		5 / 8 LEU A   3
VAL A 169
LEU A 170
ILE A  84
LEU A  23
 None
 1.22A 3kp6A-1sbzA:
undetectable
3kp6B-1sbzA:
undetectable		 3kp6A-1sbzA:
21.39
3kp6B-1sbzA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_2
(PROTEASE)		 1sbz PROBABLE AROMATIC
ACID DECARBOXYLASE
(Escherichia
coli) 		3 / 3 ARG A  52
VAL A  17
THR A  47
 None
 0.81A 3ndtA-1sbzA:
undetectable		 3ndtA-1sbzA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1sbz PROBABLE AROMATIC
ACID DECARBOXYLASE
(Escherichia
coli) 		5 / 12 ALA A  13
GLY A  12
THR A  11
ALA A  10
THR A  42
 None
None
FMN  A1401 (-4.4A)
FMN  A1401 (-3.6A)
FMN  A1401 ( 4.8A)
 1.23A 4qvpH-1sbzA:
undetectable
4qvpI-1sbzA:
undetectable		 4qvpH-1sbzA:
24.40
4qvpI-1sbzA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1sbz PROBABLE AROMATIC
ACID DECARBOXYLASE
(Escherichia
coli) 		5 / 12 ALA A  13
GLY A  12
THR A  11
ALA A  10
THR A  42
 None
None
FMN  A1401 (-4.4A)
FMN  A1401 (-3.6A)
FMN  A1401 ( 4.8A)
 1.23A 4qvpV-1sbzA:
undetectable
4qvpW-1sbzA:
undetectable		 4qvpV-1sbzA:
24.40
4qvpW-1sbzA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1sbz PROBABLE AROMATIC
ACID DECARBOXYLASE
(Escherichia
coli) 		5 / 11 ALA A  13
GLY A  12
THR A  11
ALA A  10
THR A  42
 None
None
FMN  A1401 (-4.4A)
FMN  A1401 (-3.6A)
FMN  A1401 ( 4.8A)
 1.23A 4qw0H-1sbzA:
undetectable
4qw0I-1sbzA:
undetectable		 4qw0H-1sbzA:
24.40
4qw0I-1sbzA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1sbz PROBABLE AROMATIC
ACID DECARBOXYLASE
(Escherichia
coli) 		5 / 11 ALA A  13
GLY A  12
THR A  11
ALA A  10
THR A  42
 None
None
FMN  A1401 (-4.4A)
FMN  A1401 (-3.6A)
FMN  A1401 ( 4.8A)
 1.23A 4qw0V-1sbzA:
undetectable
4qw0W-1sbzA:
undetectable		 4qw0V-1sbzA:
24.40
4qw0W-1sbzA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1sbz PROBABLE AROMATIC
ACID DECARBOXYLASE
(Escherichia
coli) 		5 / 12 ALA A  13
GLY A  12
THR A  11
ALA A  10
THR A  42
 None
None
FMN  A1401 (-4.4A)
FMN  A1401 (-3.6A)
FMN  A1401 ( 4.8A)
 1.22A 4qw1H-1sbzA:
undetectable
4qw1I-1sbzA:
undetectable		 4qw1H-1sbzA:
24.40
4qw1I-1sbzA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1sbz PROBABLE AROMATIC
ACID DECARBOXYLASE
(Escherichia
coli) 		5 / 12 ALA A  13
GLY A  12
THR A  11
ALA A  10
THR A  42
 None
None
FMN  A1401 (-4.4A)
FMN  A1401 (-3.6A)
FMN  A1401 ( 4.8A)
 1.22A 4qw1V-1sbzA:
undetectable
4qw1W-1sbzA:
undetectable		 4qw1V-1sbzA:
24.40
4qw1W-1sbzA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 1sbz PROBABLE AROMATIC
ACID DECARBOXYLASE
(Escherichia
coli) 		5 / 12 GLY A 101
SER A  72
ALA A 107
ASP A 100
ALA A  99
 None
 1.18A 4ymgB-1sbzA:
undetectable		 4ymgB-1sbzA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1sbz PROBABLE AROMATIC
ACID DECARBOXYLASE
(Escherichia
coli) 		5 / 12 ALA A  13
GLY A  12
THR A  11
ALA A  10
THR A  42
 None
None
FMN  A1401 (-4.4A)
FMN  A1401 (-3.6A)
FMN  A1401 ( 4.8A)
 1.23A 5cz7V-1sbzA:
undetectable
5cz7W-1sbzA:
undetectable		 5cz7V-1sbzA:
24.40
5cz7W-1sbzA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 1sbz PROBABLE AROMATIC
ACID DECARBOXYLASE
(Escherichia
coli) 		4 / 7 GLY A  12
VAL A 165
ILE A 161
VAL A 162
 None
 0.68A 5ik1A-1sbzA:
undetectable		 5ik1A-1sbzA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1sbz PROBABLE AROMATIC
ACID DECARBOXYLASE
(Escherichia
coli) 		5 / 12 ALA A  13
GLY A  12
THR A  11
ALA A  10
THR A  42
 None
None
FMN  A1401 (-4.4A)
FMN  A1401 (-3.6A)
FMN  A1401 ( 4.8A)
 1.23A 5l66H-1sbzA:
undetectable
5l66I-1sbzA:
undetectable		 5l66H-1sbzA:
24.40
5l66I-1sbzA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1sbz PROBABLE AROMATIC
ACID DECARBOXYLASE
(Escherichia
coli) 		5 / 12 ALA A  13
GLY A  12
THR A  11
ALA A  10
THR A  42
 None
None
FMN  A1401 (-4.4A)
FMN  A1401 (-3.6A)
FMN  A1401 ( 4.8A)
 1.23A 5l66V-1sbzA:
undetectable
5l66W-1sbzA:
undetectable		 5l66V-1sbzA:
24.40
5l66W-1sbzA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 1sbz PROBABLE AROMATIC
ACID DECARBOXYLASE
(Escherichia
coli) 		5 / 10 ALA A  39
SER A  36
GLY A  12
ALA A  10
SER A  87
 None
FMN  A1401 (-2.5A)
None
FMN  A1401 (-3.6A)
FMN  A1401 (-2.6A)
 1.32A 5l66Y-1sbzA:
undetectable
5l66Z-1sbzA:
undetectable		 5l66Y-1sbzA:
20.43
5l66Z-1sbzA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E5Z_A_CCSA106_0
(PROTEIN/NUCLEIC ACID
DEGLYCASE DJ-1)		 1sbz PROBABLE AROMATIC
ACID DECARBOXYLASE
(Escherichia
coli) 		5 / 10 GLY A 104
GLY A 101
ILE A  94
ALA A  99
GLY A  93
 None
 1.10A 6e5zA-1sbzA:
6.0		 6e5zA-1sbzA:
20.75