SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1sc0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 1sc0 HYPOTHETICAL PROTEIN
HI1161
(Haemophilus
influenzae) 		5 / 11 ILE A  28
ALA A  30
ILE A 118
LEU A  61
ILE A  65
 None
 1.07A 1dhiB-1sc0A:
undetectable		 1dhiB-1sc0A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 1sc0 HYPOTHETICAL PROTEIN
HI1161
(Haemophilus
influenzae) 		5 / 12 ILE A  28
ALA A  30
ILE A 118
LEU A  61
ILE A  65
 None
 1.08A 1draB-1sc0A:
undetectable		 1draB-1sc0A:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 1sc0 HYPOTHETICAL PROTEIN
HI1161
(Haemophilus
influenzae) 		5 / 12 ILE A  28
ALA A  30
ILE A 118
LEU A  61
ILE A  65
 None
 1.07A 2drcB-1sc0A:
undetectable		 2drcB-1sc0A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 1sc0 HYPOTHETICAL PROTEIN
HI1161
(Haemophilus
influenzae) 		5 / 11 ALA A  62
ALA A  60
HIS A  54
GLY A  55
ILE A  85
 None
 1.03A 2x1lA-1sc0A:
undetectable		 2x1lA-1sc0A:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 1sc0 HYPOTHETICAL PROTEIN
HI1161
(Haemophilus
influenzae) 		5 / 12 ILE A  28
ALA A  30
ILE A 118
LEU A  61
ILE A  65
 None
 1.08A 3drcB-1sc0A:
undetectable		 3drcB-1sc0A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1sc0 HYPOTHETICAL PROTEIN
HI1161
(Haemophilus
influenzae) 		5 / 9 ALA A 102
ALA A 100
ALA A  38
SER A  29
ALA A  69
 None
 1.32A 4twdA-1sc0A:
0.0
4twdB-1sc0A:
undetectable
4twdC-1sc0A:
0.0
4twdD-1sc0A:
undetectable
4twdE-1sc0A:
0.0		 4twdA-1sc0A:
16.77
4twdB-1sc0A:
16.77
4twdC-1sc0A:
16.77
4twdD-1sc0A:
16.77
4twdE-1sc0A:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_A_IPHA101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 1sc0 HYPOTHETICAL PROTEIN
HI1161
(Haemophilus
influenzae) 		4 / 5 CYH A 126
HIS A  54
LEU A  53
HIS A  89
 None
 1.29A 5hrqA-1sc0A:
undetectable
5hrqB-1sc0A:
undetectable
5hrqF-1sc0A:
undetectable		 5hrqA-1sc0A:
10.62
5hrqB-1sc0A:
14.17
5hrqF-1sc0A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_G_IPHG101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 1sc0 HYPOTHETICAL PROTEIN
HI1161
(Haemophilus
influenzae) 		4 / 6 HIS A  89
CYH A 126
HIS A  54
LEU A  53
 None
 1.30A 5hrqD-1sc0A:
undetectable
5hrqG-1sc0A:
undetectable
5hrqH-1sc0A:
undetectable		 5hrqD-1sc0A:
14.17
5hrqG-1sc0A:
10.62
5hrqH-1sc0A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_K_IPHK101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 1sc0 HYPOTHETICAL PROTEIN
HI1161
(Haemophilus
influenzae) 		4 / 6 HIS A  89
CYH A 126
HIS A  54
LEU A  53
 None
 1.29A 5hrqH-1sc0A:
undetectable
5hrqK-1sc0A:
undetectable
5hrqL-1sc0A:
undetectable		 5hrqH-1sc0A:
14.17
5hrqK-1sc0A:
10.62
5hrqL-1sc0A:
14.17