SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1sc6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F86_B_T44B528_1
(TRANSTHYRETIN
THR119MET VARIANT)		 1sc6 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 4 LYS A 398
LEU A 394
ALA A 406
LEU A 340
 None
 1.36A 1f86B-1sc6A:
0.0		 1f86B-1sc6A:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_B_ESTB354_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 1sc6 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 8 LEU A 370
TYR A 369
PRO A 328
VAL A 350
 None
 1.04A 1fduB-1sc6A:
5.6		 1fduB-1sc6A:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_B_DIFB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1sc6 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 9 LEU A  65
LEU A 312
VAL A 101
GLY A  80
ALA A  81
 None
 1.17A 1pxxB-1sc6A:
undetectable		 1pxxB-1sc6A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1sc6 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 10 LEU A  65
LEU A 312
VAL A 101
GLY A  80
ALA A  81
 None
 1.18A 1pxxD-1sc6A:
undetectable		 1pxxD-1sc6A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_1
(PROTEASE RETROPEPSIN)		 1sc6 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Escherichia
coli) 		6 / 12 ALA A  93
ASP A  92
GLY A  98
ILE A 404
ALA A  73
ILE A  70
 None
 1.50A 1rl8A-1sc6A:
undetectable		 1rl8A-1sc6A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_2
(PROTEASE RETROPEPSIN)		 1sc6 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Escherichia
coli) 		6 / 12 ALA A  93
ASP A  92
GLY A  98
ILE A 404
ALA A  73
ILE A  70
 None
 1.46A 1rl8B-1sc6A:
undetectable		 1rl8B-1sc6A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_B_DESB128_1
(TRANSTHYRETIN)		 1sc6 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 11 ALA A  94
LEU A  91
ALA A  81
LEU A  65
THR A  86
 None
 1.31A 1tz8A-1sc6A:
0.0
1tz8B-1sc6A:
0.0		 1tz8A-1sc6A:
17.58
1tz8B-1sc6A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)		 1sc6 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 10 ASP A 181
GLY A 163
GLY A 160
MET A 220
LEU A 209
 NAD  A2101 (-2.9A)
None
NAD  A2101 (-3.3A)
NAD  A2101 ( 4.2A)
None
 0.97A 1x7pA-1sc6A:
2.5
1x7pB-1sc6A:
2.0		 1x7pA-1sc6A:
22.97
1x7pB-1sc6A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1sc6 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 8 LEU A 354
ILE A 357
LEU A 340
HIS A 342
 None
 0.76A 2azxA-1sc6A:
undetectable		 2azxA-1sc6A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		 1sc6 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Escherichia
coli) 		3 / 3 LEU A  15
LEU A  76
PHE A  82
 None
 0.62A 2pgrA-1sc6A:
undetectable		 2pgrA-1sc6A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_A_9PLA501_1
(CYTOCHROME P450 2E1)		 1sc6 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 6 LEU A 281
ALA A 238
THR A 290
LEU A 123
 None
 1.01A 3t3zA-1sc6A:
undetectable		 3t3zA-1sc6A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_B_9PLB501_1
(CYTOCHROME P450 2E1)		 1sc6 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 6 LEU A 281
ALA A 238
THR A 290
LEU A 123
 None
 1.00A 3t3zB-1sc6A:
undetectable		 3t3zB-1sc6A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_D_9PLD501_1
(CYTOCHROME P450 2E1)		 1sc6 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 6 LEU A 281
ALA A 238
THR A 290
LEU A 123
 None
 1.00A 3t3zD-1sc6A:
undetectable		 3t3zD-1sc6A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1sc6 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 ALA A  81
ALA A 104
ALA A  23
VAL A  19
GLN A 301
 None
 1.33A 4df3B-1sc6A:
6.8		 4df3B-1sc6A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1sc6 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 11 VAL A 243
SER A 208
MET A 229
LEU A 235
VAL A 244
 None
 1.45A 4eilA-1sc6A:
2.4		 4eilA-1sc6A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		 1sc6 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 11 LEU A 115
ALA A 262
ALA A 261
ILE A 246
VAL A 244
 None
 0.88A 4h1nA-1sc6A:
undetectable		 4h1nA-1sc6A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1sc6 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 VAL A 243
SER A 208
MET A 229
LEU A 235
VAL A 244
 None
 1.49A 4kyaD-1sc6A:
undetectable		 4kyaD-1sc6A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1sc6 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 VAL A 243
SER A 208
MET A 229
LEU A 235
VAL A 244
 None
 1.47A 4kyaF-1sc6A:
undetectable		 4kyaF-1sc6A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1sc6 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 ILE A  84
GLY A  85
ILE A  79
ARG A  60
LEU A 312
 None
 1.07A 4mwzA-1sc6A:
6.3		 4mwzA-1sc6A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJ4_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1sc6 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 8 LEU A 124
LEU A 234
VAL A 206
ILE A 236
MET A 175
 None
 1.25A 4oj4A-1sc6A:
undetectable		 4oj4A-1sc6A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		 1sc6 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 6 LEU A 340
THR A 403
ALA A 406
LEU A 408
 None
 0.95A 4pwjA-1sc6A:
undetectable		 4pwjA-1sc6A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTP_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 1sc6 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 222
ALA A 223
SER A 227
ASN A 219
SER A 216
 None
None
None
None
NAD  A2101 (-2.8A)
 1.29A 4rtpA-1sc6A:
4.9		 4rtpA-1sc6A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_A_SALA801_1
(PROTEIN POLYBROMO-1)		 1sc6 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 7 ILE A 381
LEU A 332
ALA A 366
ILE A 365
 None
 0.84A 4y03A-1sc6A:
undetectable		 4y03A-1sc6A:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 1sc6 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 SER A 208
ILE A 293
ILE A 162
GLY A 163
LEU A 154
 None
None
NAD  A2101 (-3.9A)
None
None
 0.97A 4y8wC-1sc6A:
0.0		 4y8wC-1sc6A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 1sc6 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 5 SER A  26
GLY A  18
THR A  63
GLU A  17
 None
 1.21A 5btiA-1sc6A:
3.8
5btiB-1sc6A:
undetectable		 5btiA-1sc6A:
21.91
5btiB-1sc6A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1sc6 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 5 SER A  26
GLY A  18
THR A  63
GLU A  17
 None
 1.20A 5btiC-1sc6A:
3.7
5btiD-1sc6A:
1.5		 5btiC-1sc6A:
21.91
5btiD-1sc6A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_B_SALB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1sc6 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 7 VAL A 325
LEU A 312
GLY A  80
ALA A  81
 None
 0.91A 5f1aB-1sc6A:
undetectable		 5f1aB-1sc6A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1sc6 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 LEU A  65
ALA A  93
VAL A 101
GLY A  80
ALA A  81
 None
 0.92A 5jw1B-1sc6A:
undetectable		 5jw1B-1sc6A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1sc6 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 LEU A  65
ALA A  93
VAL A 101
GLY A  80
ALA A  81
 None
 1.02A 5kirA-1sc6A:
undetectable		 5kirA-1sc6A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_1
(NS3 PROTEASE)		 1sc6 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 9 PHE A  37
VAL A  19
HIS A  20
SER A 316
 None
 0.75A 6c2mD-1sc6A:
undetectable		 6c2mD-1sc6A:
9.25