SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1sch'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AEG_A_4APA296_1
(CYTOCHROME C
PEROXIDASE)		 1sch PEANUT PEROXIDASE,
MAJOR CATIONIC
ISOZYME
(Arachis
hypogaea) 		4 / 8 HIS A 169
GLY A 172
LEU A 236
ASP A 239
 HEM  A 300 ( 3.3A)
HEM  A 300 (-3.4A)
HEM  A 300 ( 4.9A)
None
 0.39A 1aegA-1schA:
25.0		 1aegA-1schA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_2
(MINERALOCORTICOID
RECEPTOR)		 1sch PEANUT PEROXIDASE,
MAJOR CATIONIC
ISOZYME
(Arachis
hypogaea) 		3 / 3 LEU A  37
LEU A 101
MET A 273
 HEM  A 300 ( 4.5A)
None
HEM  A 300 ( 4.7A)
 0.80A 1ya3B-1schA:
undetectable		 1ya3B-1schA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 1sch PEANUT PEROXIDASE,
MAJOR CATIONIC
ISOZYME
(Arachis
hypogaea) 		5 / 12 LEU A  39
ASP A  81
ILE A  80
ASP A  57
GLY A  63
 None
 1.08A 1zz1C-1schA:
undetectable		 1zz1C-1schA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 1sch PEANUT PEROXIDASE,
MAJOR CATIONIC
ISOZYME
(Arachis
hypogaea) 		4 / 7 ILE A 183
ASP A 239
LEU A 235
GLY A 234
 None
 0.89A 2tsrA-1schA:
undetectable		 2tsrA-1schA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA802_1
(PROSTAGLANDIN
REDUCTASE 1)		 1sch PEANUT PEROXIDASE,
MAJOR CATIONIC
ISOZYME
(Arachis
hypogaea) 		4 / 7 VAL A 252
TYR A 226
ASN A 228
GLY A 234
 None
 0.83A 2y05A-1schA:
undetectable
2y05B-1schA:
undetectable		 2y05A-1schA:
22.88
2y05B-1schA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1sch PEANUT PEROXIDASE,
MAJOR CATIONIC
ISOZYME
(Arachis
hypogaea) 		3 / 3 ASN A  70
MET A  32
PHE A  77
 None
 0.98A 3g4lD-1schA:
undetectable		 3g4lD-1schA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_H_SAMH226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1sch PEANUT PEROXIDASE,
MAJOR CATIONIC
ISOZYME
(Arachis
hypogaea) 		5 / 12 LEU A 101
GLY A 172
ALA A 105
LEU A 112
ILE A 171
 None
HEM  A 300 (-3.4A)
None
None
None
 1.02A 3ku1H-1schA:
undetectable		 3ku1H-1schA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_E_9PLE1_1
(CYTOCHROME P450 2A13)		 1sch PEANUT PEROXIDASE,
MAJOR CATIONIC
ISOZYME
(Arachis
hypogaea) 		4 / 8 PHE A 152
PHE A 157
ALA A 269
PHE A  41
 HEM  A 300 (-4.7A)
None
None
HEM  A 300 ( 4.0A)
 1.11A 3t3sE-1schA:
undetectable		 3t3sE-1schA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LZR_A_LOCA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1sch PEANUT PEROXIDASE,
MAJOR CATIONIC
ISOZYME
(Arachis
hypogaea) 		4 / 8 VAL A  22
LEU A  36
ASP A  99
ILE A 100
 None
 0.89A 4lzrA-1schA:
undetectable		 4lzrA-1schA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_A_ESTA2000_1
(ESTROGEN RECEPTOR)		 1sch PEANUT PEROXIDASE,
MAJOR CATIONIC
ISOZYME
(Arachis
hypogaea) 		5 / 12 LEU A  36
ALA A 105
LEU A 112
GLY A 167
HIS A 169
 None
None
None
None
HEM  A 300 ( 3.3A)
 1.13A 4pxmA-1schA:
undetectable		 4pxmA-1schA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_F_TR6F101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 1sch PEANUT PEROXIDASE,
MAJOR CATIONIC
ISOZYME
(Arachis
hypogaea) 		4 / 5 GLY A 172
ARG A  31
GLY A  33
GLU A  29
 HEM  A 300 (-3.4A)
HEM  A 300 (-4.1A)
None
None
 1.04A 4z2eB-1schA:
undetectable
4z2eC-1schA:
undetectable		 4z2eB-1schA:
20.85
4z2eC-1schA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 1sch PEANUT PEROXIDASE,
MAJOR CATIONIC
ISOZYME
(Arachis
hypogaea) 		5 / 10 ILE A 100
GLY A  76
LEU A  36
ALA A 104
ASP A 107
 None
 1.48A 5ajqB-1schA:
undetectable		 5ajqB-1schA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXG_B_ESTB601_1
(ESTROGEN RECEPTOR)		 1sch PEANUT PEROXIDASE,
MAJOR CATIONIC
ISOZYME
(Arachis
hypogaea) 		5 / 11 LEU A  36
ALA A 105
LEU A 112
GLY A 167
HIS A 169
 None
None
None
None
HEM  A 300 ( 3.3A)
 1.18A 5dxgB-1schA:
0.5		 5dxgB-1schA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1sch PEANUT PEROXIDASE,
MAJOR CATIONIC
ISOZYME
(Arachis
hypogaea) 		5 / 10 ALA A 105
GLY A  76
ALA A 104
HIS A  42
ILE A  80
 None
 1.19A 5eeuF-1schA:
undetectable
5eeuG-1schA:
undetectable		 5eeuF-1schA:
15.07
5eeuG-1schA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1sch PEANUT PEROXIDASE,
MAJOR CATIONIC
ISOZYME
(Arachis
hypogaea) 		5 / 10 ALA A 105
GLY A  76
ALA A 104
HIS A  42
ILE A  80
 None
 1.19A 5eevF-1schA:
undetectable
5eevG-1schA:
undetectable		 5eevF-1schA:
15.07
5eevG-1schA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1sch PEANUT PEROXIDASE,
MAJOR CATIONIC
ISOZYME
(Arachis
hypogaea) 		5 / 10 ALA A 105
GLY A  76
ALA A 104
HIS A  42
ILE A  80
 None
 1.19A 5eeyF-1schA:
undetectable
5eeyG-1schA:
undetectable		 5eeyF-1schA:
15.07
5eeyG-1schA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1sch PEANUT PEROXIDASE,
MAJOR CATIONIC
ISOZYME
(Arachis
hypogaea) 		5 / 10 ALA A 105
GLY A  76
ALA A 104
HIS A  42
ILE A  80
 None
 1.19A 5eezF-1schA:
undetectable
5eezG-1schA:
undetectable		 5eezF-1schA:
15.07
5eezG-1schA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1sch PEANUT PEROXIDASE,
MAJOR CATIONIC
ISOZYME
(Arachis
hypogaea) 		5 / 10 ALA A 105
GLY A  76
ALA A 104
HIS A  42
ILE A  80
 None
 1.20A 5ef2F-1schA:
undetectable
5ef2G-1schA:
undetectable		 5ef2F-1schA:
15.07
5ef2G-1schA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1sch PEANUT PEROXIDASE,
MAJOR CATIONIC
ISOZYME
(Arachis
hypogaea) 		5 / 10 ALA A 105
GLY A  76
ALA A 104
HIS A  42
ILE A  80
 None
 1.20A 5ef3F-1schA:
undetectable
5ef3G-1schA:
undetectable		 5ef3F-1schA:
15.07
5ef3G-1schA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		 1sch PEANUT PEROXIDASE,
MAJOR CATIONIC
ISOZYME
(Arachis
hypogaea) 		4 / 8 SER A  96
ASP A  99
PHE A   6
SER A   3
 None
None
None
PCA  A   1 ( 4.3A)
 1.10A 5l1fA-1schA:
undetectable
5l1fB-1schA:
undetectable		 5l1fA-1schA:
16.14
5l1fB-1schA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_E_D16E402_1
(THYMIDYLATE SYNTHASE)		 1sch PEANUT PEROXIDASE,
MAJOR CATIONIC
ISOZYME
(Arachis
hypogaea) 		4 / 6 ILE A 183
ASP A 239
LEU A 235
GLY A 234
 None
 0.99A 5x5qE-1schA:
undetectable		 5x5qE-1schA:
20.61